Diffuse reflectance spectroscopy for monitoring diabetic foot ulcer – A pilot study

Anand, Suresh; Sujatha, N.; Narayanamurthy, V. B.; Varadarajan, Seshadri; Poddar, Richa

doi:10.1016/j.optlaseng.2013.07.020

Cited by 38 publications

(25 citation statements)

References 32 publications

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“…Several research groups have implemented NIR optical imaging technology on wound imaging (chronic wounds and DFUs) with animal studies as well as pilot human subject studies. 5,[7][8][9][10][11][12][13][14][15][16][17] A summary of all the studies conducted with implementation of NIRS is listed in Table 1. Papazoglou's group and Weingarten's group at Drexel University conducted animal studies and a pilot human study to show that NIRS is capable of predicting wound healing in DFUs. [8][9][10][11][12][13][14] Moza et al developed a multiwavelength imager (no contact at the source end, but contact at the detector end) with real-time imaging display and demonstrated that NIRS is capable of imaging perfusion from studies on normal hands.…”

Section: Near-infrared Optical Imagingmentioning

confidence: 99%

Assessing the Healing of Venous Leg Ulcers Using a Noncontact Near-Infrared Optical Imaging Approach

Lei

Rodríguez

Jayachandran

et al. 2018

Advances in Wound Care

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Venous leg ulcers (VLUs) are one of the most common complications in lower extremity wounds. To date, clinicians employ visual inspection of the wound site during its healing process by monitoring surface granulation and reduction in wound size across weeks of treatment. In this study, a handheld near-infrared optical scanner (NIROS) has been developed at the Optical Imaging Laboratory to differentiate healing from nonhealing VLUs based on differences in blood flow to the wound and its surroundings. Noncontact near-infrared (NIR) area imaging of 12 VLUs have been carried out at two podiatric clinics. Diffuse reflectance images of the wounds were used to quantify optical contrasts between the wound and its surroundings. The variability in imaging conditions, analysis, and operator dependency were assessed to determine the robustness of the imaging approach. Optical contrast obtained from diffuse reflectance images of VLUs were distinctly different for healing (positive contrast) and nonhealing (negative contrast) wounds, independent of the varying imaging and data analysis conditions. NIR imaging of wounds to differentiate healing from nonhealing VLUs using a noncontact wide-area imager has been demonstrated for the first time. The application of a portable handheld imager to assess the healing or nonhealing nature of VLUs during weekly clinical treatment is significant since physiological changes, as observed using NIROS, manifest before visual reduction in wound size during the healing process.

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Section: Near-infrared Optical Imagingmentioning

confidence: 99%

Assessing the Healing of Venous Leg Ulcers Using a Noncontact Near-Infrared Optical Imaging Approach

Lei

Rodríguez

Jayachandran

et al. 2018

Advances in Wound Care

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“…into the sample where it is reflected, scattered, and then transmitted through the sample material. 9,25 The scattered light that is back-reflected is then collected by the accessory and directed to the detector optics. The beam that is scattered within a sample and then returned to the surface is known as diffuse reflection.…”

Section: Near-infrared Spectroscopymentioning

confidence: 99%

“…There has been only one study using DRS for imaging of DFUs. 25 The DRS device employed a broadband, tungsten halogen light source between 400 and 800 nm and a CCD spectrometer detector. Tissue ISO 2 , HbO, HbR, and total hemoglobin (HbT) were evaluated to demonstrate that DRS is capable of monitoring changes in oxygen dynamics of DFUs.…”

Section: Near-infrared Spectroscopymentioning

confidence: 99%

Critical Review of Noninvasive Optical Technologies for Wound Imaging

Jayachandran

Rodríguez

Solis

et al. 2016

Advances in Wound Care

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“…All the subjects were asked to clean their foot, and the measurement was taken from the metatarsal region of the foot uniformly. The selection of metatarsal region as the region of interest was made based on previous research on diabetic foot to extract oxygenation flow details by our group [1]. Also, this region is one among the regions in the foot sole, prone to develop ulcer with the more predominant changes in flow dynamics due to exerted walking pressure.…”

Section: Experimental Set-upmentioning

confidence: 99%

Correlation analysis of laser Doppler flowmetry signals: a potential non-invasive tool to assess microcirculatory changes in diabetes mellitus

Lal

Sujatha

2015

Med Biol Eng Comput

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Measurement and analysis of microcirculation is vital in assessing local and systemic tissue health. Changes in microvascular perfusion if detected can provide information on the development of various related diseases. Laser Doppler blood flowmetry (LDF) provides a non-invasive real-time measurement of cutaneous blood perfusion. LDF signals possess fractal nature that represents the correlation in the successive signal elements. Changes in the correlation of flow and its associated parameters could be used as a tool in differentiating the ailments at different stages or assessing the treatment effectiveness of a particular ailment. Spectral domain analysis of LDF signals reveals five characteristic frequency peaks corresponding to local and central regulatory mechanisms of the human body, namely metabolic, neurogenic, myogenic, respiration, and heart rate. This paper investigates the changes in the fractal nature and constituent frequency bands of laser Doppler signals in diabetic and healthy control subjects acquired from the glabrous skin of the foot so as to provide an assessment of microcirculatory dynamics. As a pilot study, it was attempted on a set of healthy control and diabetic volunteers, and the obtained results indicate that fractal nature of LDF signals is less in diabetic subjects compared to the healthy control. The wavelet analysis carried out on the set of signals reveals the dynamics of blood flow which may have led to the difference in correlation results.

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Diffuse reflectance spectroscopy for monitoring diabetic foot ulcer – A pilot study

Cited by 38 publications

References 32 publications

Assessing the Healing of Venous Leg Ulcers Using a Noncontact Near-Infrared Optical Imaging Approach

Assessing the Healing of Venous Leg Ulcers Using a Noncontact Near-Infrared Optical Imaging Approach

Critical Review of Noninvasive Optical Technologies for Wound Imaging

Correlation analysis of laser Doppler flowmetry signals: a potential non-invasive tool to assess microcirculatory changes in diabetes mellitus

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