Diffuse sclerosing variant of papillary carcinoma of the thyroid: ultrasound features with histopathological correlation

New clinical features of thyroid cancer in eastern China

“…Between 38 and 50% of the thyroid nodules with diffuse and scattered microcalcifications are eventually shown to be malignant [6,7]. Only 13.1% of benign nodules have calcifications, most of which are larger than those seen in the malignant nodules [8]. Scattered calcifications perceived in papillary thyroid carcinoma are related to psammoma bodies at histopathological review.…”

Computerized analysis of calcification of thyroid nodules as visualized by ultrasonography

“…Calcification can occur in both malignant and benign thyroid nodules [5,7,14]; however, several studies have noted that calcifications are more common in malignant thyroid nodules, and that the specific calcification pattern is an important sign of thyroid malignancy [16,28,29]. Microcalcification on thyroid US is generally accepted as the most reliable indicator of malignancy [4,16] and is particularly specific for papillary thyroid cancer [30].…”

Ultrasonographic Features of Diffuse Sclerosing Variant of Papillary Thyroid Carcinoma

“…Many authors reported the clinical and cytopathological features of this entity [6,12,13]. Only a few case reports and small series regarding this entity correlating with imaging findings have been reported in the literature [10,14,15]. However, the report of sonographic features of this entity in larger series is rare.…”

“…Kwak et al [10] reported the histopathological features of DSVPTC as diffuse involvement of the thyroid gland with dense fibrosis, extensive squamous metaplasia, patchy lymphoid infiltration with germinal centers, psammoma bodies, and some areas within the smear showing typical papillary carcinoma.…”