Diffuse skeletal muscle extramedullary plasmacytomas: a rare case and review of the literature

Moore, Robert D.; Nelson, Steve; Cecava, Nathan D.

doi:10.1007/s00256-020-03514-9

Cited by 4 publications

(13 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In human medicine, primary muscle EMP without systemic MM has only been described in isolated case reports 11 . Secondary intramuscular plasmacytomas more frequently occur in association with MM because of bone lesions spreading to adjacent muscles 11,12 . Intramuscular plasma cell tumours may be discovered during initial workup for intramedullary disease or may occur during MM relapse 12 .…”

Section: Discussionmentioning

confidence: 99%

“…CT showed a diffuse swelling of the sternohyoid and triceps muscles. In humans, tumours mainly involve muscles of the trunk and occur predominantly in one muscle 11,12 . The disease manifests with two patterns in equal proportion, either as an intramuscular mass or a diffuse infiltration of the muscle 11 .…”

Section: Discussionmentioning

confidence: 99%

“…The disease manifests with two patterns in equal proportion, either as an intramuscular mass or a diffuse infiltration of the muscle 11 . There is one case report of a deltoid muscle EMP with intralesional haemorrhage 12 . These data suggest that false‐negative biopsy results could be prevented with careful examination of imaging features in order to help sample the lesion of interest.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Disseminated intramuscular anaplastic plasma cell tumour in a dog

Lecot,

Chamel,

Marchal

et al. 2023

Vet Record Case Reports

View full text Add to dashboard Cite

A 12‐year‐old, neutered, male Jack Russell terrier was diagnosed with a disseminated intramuscular anaplastic round cell tumour with primary hepatic, splenic, subcutaneous and medullary involvement. The tumour was confirmed by histopathology, immunohistochemistry and polymerase chain reaction analysis of antigen receptor gene rearrangements to be of plasma cell origin. Tumour cells were lambda light chain‐positive, multiple myeloma 1‐positive and pan‐B marker‐negative (paired box protein 5, CD20 and CD79) and showed clonal immunoglobulin heavy chain gene rearrangement. Computed tomography did not identify osteolytic lesions. Plasma cells represented 14% of bone marrow cells. Serum and urine electrophoresis were not performed because of a normal serum globulin concentration. To the authors’ knowledge, this is the first case report describing a disseminated diffuse intramuscular anaplastic plasma cell tumour in a dog without evidence of multiple myeloma on initial presentation or progression to multiple myeloma or plasma cell leukaemia during follow‐up.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Disseminated intramuscular anaplastic plasma cell tumour in a dog

Lecot,

Chamel,

Marchal

et al. 2023

Vet Record Case Reports

View full text Add to dashboard Cite

show abstract

“…Multiple myeloma may combine with AL amyloidosis-associated myopathy or SLONM-MGUS ( 33 ). Meanwhile, given that multiple myeloma accounts for the majority of plasma cell neoplasms, myeloma with muscular infiltrations, particularly those that have relapsed as intramuscular extramedullary plasmacytomas, should not be overlooked ( 34 , 35 ). In summary, although a few case reports suggest that other MGCS or multiple myeloma can cause myopathy, the evidence is insufficient to establish a clear correlation between the other MGCS/multiple myeloma and myopathy based on current knowledge ( 36 , 37 ).…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

Case Report: Monoclonal Gammopathies of Clinical Significance-Associated Myopathy: A Case-Based Review

Du²,

Zhang³

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

Monoclonal gammopathies of clinical significance (MGCS)-associated myopathy is a group of muscular MGCS-based rare manifestations. It mainly includes amyloid light chain (AL) amyloidosis and sporadic late-onset nemaline myopathy with monoclonal gammopathy of undetermined significance. When myopathy manifests as the initial or sole clinical symptom, it can often be delayed or misdiagnosed as other myopathies. We report the case of a 60-year-old man who initially presented with fatigue and muscle weakness of the symmetric proximal lower limbs. Muscle biopsy did not reveal mononuclear cell infiltration, atrophy, necrosis, or positive Congo red staining results. The results of serum protein electrophoresis and immunofixation electrophoresis were negative. No specific diagnosis was established. After 1 year, the patient was diagnosed with AL amyloidosis after myocardial and fat pad biopsies were performed and myopathy was diagnosed as AL amyloidosis-associated myopathy after reassessment. The patient received CyBorD regime chemotherapy and achieved hematological and organ remission. Therefore, we reviewed the clinical and pathological manifestations of MGCS-associated myopathies. Based on published articles and the present case, we conclude that comprehensive screening for MGCS in unexplained myopathy is essential to avoid misdiagnosis or delayed diagnosis.

show abstract

“…Plasmacytoma and MM may occur intramedullary (bone) or extramedullary (soft tissue). Solitary extramedullary plasmacytoma (SEP) is epidemiologically rare, representing only 4% of all plasma cell neoplasms [2]. Secondary SEP frequently occurs due to a direct infiltration from adjacent intramedullary MM [3].…”

Section: Introductionmentioning

confidence: 99%

A Rare Case of Unresectable Solitary Extramedullary Plasmacytoma at the Shoulder Region: Case Report

Putro

Ekaputra

Cein

et al. 2022

Open Access Maced J Med Sci

View full text Add to dashboard Cite

INTRODUCTION: Plasmacytoma is a solitary neoplastic lesion marked by a localized accumulation of monoclonal plasma cells without an evidence of a systemic proliferation. Plasmacytoma may arise in intramedullar (bone) or extramedullar (soft tissue). Extramedullary plasmacytoma is rare, with the most frequent locations in the nasal cavity and nasopharynx. Here, we describe a case of solitary extramedullary plasmacytoma of the shoulder region. CASE REPORT: A 49-year-old male patient presented with right shoulder mass that was solid, fixed, ulcerated, and poorly circumscribed, with size 20 × 15 × 10 cm. Shoulder X-ray and MRI results revealed a soft-tissue mass on the right shoulder with the destruction of lateral part of the right clavicle. Biopsy results suggested Non-Hodgkin Lymphoma; however, first panel of immunohistochemical (IHC) analysis showed negative staining of LCA, CK, CD20, and CD3, with high Ki67. Second panel of IHC revealed negative staining of ALK, TdT, and CD79a; meanwhile, CD138 was strongly expressed. Further hematological, biochemical, and radiological examinations that revealed no systemic involvement supported the diagnosis of solitary extramedullary plasmacytoma. Patient received radiotherapy treatment 60 Gy in 30 fractions and zometa within 4 weeks interval and showed remarkable response of the therapy. DISCUSSION: Solitary extramedullary (soft tissue) plasmacytomas (SEP) are less common than solitary bone plasmacytoma (SBP), yet it has a better prognosis since the majority can be cured by local radiotherapy. CONCLUSION: We report a case of SEP of the shoulder that showed remarkable response of therapy. In this case report, radiotherapy was shown to be a highly effective modality to treat a patient with solitary extramedullary plasmacytoma.

show abstract

Diffuse skeletal muscle extramedullary plasmacytomas: a rare case and review of the literature

Cited by 4 publications

References 14 publications

Disseminated intramuscular anaplastic plasma cell tumour in a dog

Disseminated intramuscular anaplastic plasma cell tumour in a dog

Case Report: Monoclonal Gammopathies of Clinical Significance-Associated Myopathy: A Case-Based Review

A Rare Case of Unresectable Solitary Extramedullary Plasmacytoma at the Shoulder Region: Case Report

Contact Info

Product

Resources

About