Diffuse sources of contamination in freshwater fish: Detecting effects through active biomonitoring and multi-biomarker approaches

Santana, Manuela S.; Yamamoto, Fábio Iuji; Sandrini-Neto, Leonardo; Neto, Francisco Filipak; Ortolani-Machado, Claudia Feijó; Ribeiro, Ciro Alberto de Oliveira; Prodocimo, Maritana Mela

doi:10.1016/j.ecoenv.2017.11.036

Cited by 32 publications

(6 citation statements)

References 59 publications

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“…In general, dose-dependent in ammatory responses occurred only after exposure to BDE-209, and it was corroborated by the results of Santana et al (2018).…”

Section: Discussionsupporting

confidence: 65%

Comparative toxicity of trophic exposures to polybrominated compounds (2, 4, 6 - Tribromophenol and BDE-209) to Oreochromis niloticus (Linnaeus, 1758)

Ribeiro

Bozza

Esquivel³

et al. 2021

Preprint

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In the last decades, there has been an increase in demand for new polymers, including flame-retardants compounds, to meet fire prevention by international safety standards. The decabromodiphenyl ether (BDE-209) is a polybrominated diphenyl ether (PBDE) congener still in use worldwide. This compound presents lipophilic properties and so is easily bioaccumulated in the food chain. The 2, 4, 6 - Tribromophenol (TBP) is a PBDE metabolite also used as pesticide and flame-retardant for wood conservation. In the current study, the acute and chronic toxicity of BDE-209 and TBP was evaluated in Oreochromis niloticus through the analyses of redox unbalance, neurotoxicity and histopathological biomarkers after acute (24, 48, 72 and 96 h) and chronic (90 days) exposures to 0.5, 5 and 50 ng/g of the PBDEs. The results showed effects in GST activity and damage to biomolecules in both acute and chronic exposures. Histopathological findings were observed in the acute experiment, while hepatocyte lesions were found in both experiments. Only BDE-209 presented neurotoxic effects. The current study revealed new endpoints related with polybrominated compounds in fish, highlighting the needs to review the risk of exposure to biota and human populations.

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“…In general, dose-dependent in ammatory responses occurred only after exposure to BDE-209, and it was corroborated by the results of Santana et al (2018).…”

Section: Discussionsupporting

confidence: 65%

Comparative toxicity of trophic exposures to polybrominated compounds (2, 4, 6 - Tribromophenol and BDE-209) to Oreochromis niloticus (Linnaeus, 1758)

Ribeiro

Bozza

Esquivel³

et al. 2021

Preprint

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“…A N U S C R I P T 12 are unknown; thus, the effects on cells, tissues, organs and systems can be identified as the only target in the risk assessment. Different morphological findings linked to the exposure to organic pollutants have been described in cells and tissues, such as inflammation, necrosis, apoptosis, and sometimes hypertrophy or hyperplasia (Chen et al, 2016) (Cheng et al, 2015) (Ray et al, 2015) (Kumar et al, 2017) (Santana et al, 2018)(Vicario-Parés et al, 2018. Tissues, organs and systems are involved in vertebrate toxicokinetics: integument, respiratory and digestive organs are firstly subjected to pollutant exposure, due to their direct interface with the outside (Fatima et al, 2014) (Alves et al, 2016 (Salamat and Zarie, 2016) (Strzyzewska et al, 2016); besides, nervous, immune, and endocrine systems are mostly studied (Kumari and Khare, 2018) (Lonappan et al, 2016) (Vogt et al, 2018) (Xu et al, 2018) (Gambardella et al, 2016) (Adeogun et al, 2016) (Hicks et al, 2017) (Tulloch et al, 2016a).…”

Section: A C C E P T E D Mmentioning

confidence: 99%

Opinion paper about organic trace pollutants in wastewater: Toxicity assessment in a European perspective

Pedrazzani

Bertanza

Brnardić

et al. 2019

Science of The Total Environment

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This opinion paper focuses on the role of eco-toxicological tools in the assessment of possible impacts of emerging contaminants on the aquatic ecosystem, hence, on human health. Indeed, organic trace pollutants present in raw and treated wastewater are the pivot targets: a multidisciplinary approach allows defining the basic principles for managing this issue, from setting a proper monitoring campaign up to evaluating the optimal process treatment. Giving hints on trace pollutants fate and behaviour, attention is focused on the choice of the bioassay(s), by analysing the meaning of possible biological answers. Data interpretation and exploitation are detailed with the final goal of providing criteria in order to be able to select the best targeted treatment options.The manuscript deals with conventional and innovative analytical approaches for assessing toxicity, by reviewing laboratory and field assays; illustrative real scale and laboratory applications integrate and exemplify the proposed approach.

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“…In this paper, we report the assessment of the health status of two of the most abundant and widely distributed fish species: the European eel (Anguilla anguilla) and the brown trout (Salmo trutta fario). As reported by scientific studies, fish represent an excellent tool in the biomonitoring of aquatic environments [4,34]. However, as suggested by Griffiths [35], the use of only one fish species as a bioindicator of an aquatic environment may cause some problems mainly related to the narrowness of the fish zoning.…”

Section: Discussionmentioning

confidence: 99%

“…The pollution of the aquatic environment is a serious and growing problem caused by anthropogenic activities, such as industry, agriculture, and trade [1][2][3]. The resulting low quality of water negatively affects the life of aquatic organisms by inducing stress and compromising the general health status [4]. Rivers and lakes represent the aquatic ecosystems most threatened by the casual release of xenobiotic substances and different kinds of waste [5].…”

Section: Introductionmentioning

confidence: 99%

A Deep Survey of Fish Health for the Recognition of Useful Biomarkers to Monitor Water Pollution

Orso,

Imperatore,

Coccia

et al. 2023

Environments

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The aim of the present study was to evaluate the wild freshwater fish health status using a vast array of biomarkers as predictive factors of pollutant exposure. The European eel (Anguilla anguilla) and brown trout (Salmo trutta fario), resident in rivers with different degrees of pollution in the South of Italy (Picentino River with good environmental quality and Tusciano River with low environmental quality), were examined using biometric parameters, histopathological and immunohistochemical biomarkers to evaluate the health status and a possible correlation with the water quality. Several alterations identified in the liver positively correlated with water and soil pollutants: hemorrhage (p ≤ 0.05), cytoplasmic vacuolization (p ≤ 0.01), hemosiderosis (p ≤ 0.05), irregular arrangement of hepatocytes (p ≤ 0.01), lipid accumulation (p ≤ 0.05), necrosis (p ≤ 0.01), cellular hyperplasia (p ≤ 0.05), leukocyte infiltration (p ≤ 0.01) and melanomacrophages centers (MMC) (p ≤ 0.01). In the spleen, only hemosiderosis correlated with water and soil pollutants (p ≤ 0.05). The inflammatory biomarker tumor necrosis factor α (TNFα) and ciclooxigenase 2 (COX2) responded to the environmental pollution, as well as the oxidative stress biomarkers superoxide dismutase (SOD2) and 8-Hydroxy-2′-deoxyguanosine (8-OHdG). Erythrocytic nuclear abnormalities and erythrocytic cellular abnormalities were found to be significantly higher in the blood of both the European eel (p < 0.0001) and brown trout (p < 0.001) in the Tusciano River compared with the Picentino River. Taken together, these results outline the need to increase the number of suitable biomarkers to assess fish health and reinforce the importance of employing additional biomarkers in biomonitoring programs that can be applied to evaluate water quality and in environmental assessment around the world.

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Diffuse sources of contamination in freshwater fish: Detecting effects through active biomonitoring and multi-biomarker approaches

Cited by 32 publications

References 59 publications

Comparative toxicity of trophic exposures to polybrominated compounds (2, 4, 6 - Tribromophenol and BDE-209) to Oreochromis niloticus (Linnaeus, 1758)

Comparative toxicity of trophic exposures to polybrominated compounds (2, 4, 6 - Tribromophenol and BDE-209) to Oreochromis niloticus (Linnaeus, 1758)

Opinion paper about organic trace pollutants in wastewater: Toxicity assessment in a European perspective

A Deep Survey of Fish Health for the Recognition of Useful Biomarkers to Monitor Water Pollution

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