Diffusion alterations associated with Parkinson's disease symptomatology: A review of the literature

Jm, Hall; Martens, Kaylena A. Ehgoetz; Walton, Courtney C.; O’Callaghan, Claire; Keller, Peter E.; Lewis, Simon J.G.; Moustafa, Ahmed A.

doi:10.1016/j.parkreldis.2016.09.026

Cited by 75 publications

(59 citation statements)

References 94 publications

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“…DTI indices are reportedly sensitive, but not specific, to microstructural changes (Andersson & Sotiropoulos, ). Decreases in FA may arise not only from the axonal loss but also from demyelination and changes in the size of axons (Hall et al, ). Furthermore, AD and RD may provide an acceptable approximation if the voxel includes a healthy fiber bundle determining the diffusion characteristic of the voxel.…”

Section: Discussionmentioning

confidence: 99%

Neurocognitive and psychiatric disorders‐related axonal degeneration in Parkinson's disease

Andica

Kamagata

Hatano

et al. 2020

J of Neuroscience Research

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Neurocognitive and psychiatric disorders have significant consequences for quality of life in patients with Parkinson's disease (PD). In the current study, we evaluated microstructural white matter (WM) alterations associated with neurocognitive and psychiatric disorders in PD using neurite orientation dispersion and density imaging (NODDI) and linked independent component analysis (LICA). The indices of NODDI were compared between 20 and 19 patients with PD with and without neurocognitive and psychiatric disorders, respectively, and 25 healthy controls using tract‐based spatial statistics and tract‐of‐interest analyses. LICA was applied to model inter‐subject variability across measures. A widespread reduction in axonal density (indexed by intracellular volume fraction [ICVF]) was demonstrated in PD patients with and without neurocognitive and psychiatric disorders, as compared with healthy controls. Compared with patients without neurocognitive and psychiatric disorders, patients with neurocognitive and psychiatric disorders exhibited more extensive (posterior predominant) decreases in axonal density. Using LICA, ICVF demonstrated the highest contribution (59% weight) to the main effects of diagnosis that reflected widespread decreases in axonal density. These findings suggest that axonal loss is a major factor underlying WM pathology related to neurocognitive and psychiatric disorders in PD, whereas patients with neurocognitive and psychiatric disorders had broader axonal pathology, as compared with those without. LICA suggested that the ICVF can be used as a useful biomarker of microstructural changes in the WM related to neurocognitive and psychiatric disorders in PD.

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Section: Discussionmentioning

confidence: 99%

Neurocognitive and psychiatric disorders‐related axonal degeneration in Parkinson's disease

Andica

Kamagata

Hatano

et al. 2020

J of Neuroscience Research

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“…This smallworldness has been shown to be disrupted in PD patients if they also present with mild cognitive impairment (Galantucci et al, 2017). All these advances have improved our understanding of the structural changes that underlie clinical symptoms of PD (Hall et al, 2016), and may also help in classifying healthy controls or patients with other neurodegeneration diseases (Cochrane & Ebmeier, 2013).…”

Section: Introductionmentioning

confidence: 99%

Regional and network properties of white matter function in Parkinson's disease

Cuiping

Liu

et al. 2018

Human Brain Mapping

106

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Parkinson's disease (PD) is a neurodegenerative disorder with dysfunction in cortices as well as white matter (WM) tracts. While the changes to WM structure have been extensively investigated in PD, the nature of the functional changes to WM remains unknown. In this study, the regional activity and functional connectivity of WM were compared between PD patients (n = 57) and matched healthy controls (n = 52), based on multimodel magnetic resonance imaging data sets. By tract‐based spatial statistical analyses of regional activity, patients showed decreased structural‐functional coupling in the left corticospinal tract compared to controls. This tract also displayed abnormally increased functional connectivity within the left post‐central gyrus and left putamen in PD patients. At the network level, the WM functional network showed small‐worldness in both controls and PD patients, yet it was abnormally increased in the latter group. Based on the features of the WM functional connectome, previously un‐evaluated individuals could be classified with fair accuracy (73%) and area under the curve of the receiver operating characteristics (75%). These neuroimaging findings provide direct evidence for WM functional changes in PD, which is crucial to understand the functional role of fiber tracts in the pathology of neural circuits.

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“…DTI is in a vast number of PD imaging manuscripts, including a 2008 study from our institution that showed structural changes in cognitively-normal PD subjects [50]. Recent reviews outline the presence of changes in early PD subjects, and the association between changes in fractional anisotropy (FA) and motor severity [19,51,52,53,54]. The review by Hall et al delves into the search for DTI correlates to motor, cognitive, mood and other features such as hallucinations/psychosis, rapid eye movement sleep behavior disorder (RBD), and autonomic dysfunction in people with PD [54].…”

Section: Structural Imagingmentioning

confidence: 99%

“…Recent reviews outline the presence of changes in early PD subjects, and the association between changes in fractional anisotropy (FA) and motor severity [19,51,52,53,54]. The review by Hall et al delves into the search for DTI correlates to motor, cognitive, mood and other features such as hallucinations/psychosis, rapid eye movement sleep behavior disorder (RBD), and autonomic dysfunction in people with PD [54]. These authors highlighted the challenges whereby different DTI MRI methodologies are employed at different centers, as well as the need for a large cohort of mildly affected subjects to demonstrate structural changes in early PD.…”

Section: Structural Imagingmentioning

confidence: 99%

Brain Magnetic Resonance Imaging (MRI) as a Potential Biomarker for Parkinson’s Disease (PD)

Tuite

2017

Brain Sciences

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Magnetic resonance imaging (MRI) has the potential to serve as a biomarker for Parkinson’s disease (PD). However, the type or types of biomarker it could provide remain to be determined. At this time there is not sufficient sensitivity or specificity for MRI to serve as an early diagnostic biomarker, i.e., it is unproven in its ability to determine if a single individual is normal, has mild PD, or has some other forms of degenerative parkinsonism. However there is accumulating evidence that MRI may be useful in staging and monitoring disease progression (staging biomarker), and also possibly as a means to monitor pathophysiological aspects of disease and associated response to treatments, i.e., theranostic marker. As there are increasing numbers of manuscripts that are dedicated to diffusion- and neuromelanin-based imaging methods, this review will focus on these topics cursorily and will delve into pharmacodynamic imaging as a means to get at theranostic aspects of PD.

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Diffusion alterations associated with Parkinson's disease symptomatology: A review of the literature

Cited by 75 publications

References 94 publications

Neurocognitive and psychiatric disorders‐related axonal degeneration in Parkinson's disease

Neurocognitive and psychiatric disorders‐related axonal degeneration in Parkinson's disease

Regional and network properties of white matter function in Parkinson's disease

Brain Magnetic Resonance Imaging (MRI) as a Potential Biomarker for Parkinson’s Disease (PD)

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