This article summarizes briefly the contributions presented in this EuroCyberSecurity Workshop 2021 which is organized as part of the series of International Symposia on Computer and Information Sciences (ISCIS), with the support of the European Commission funded IoTAC Project, that was held on November and in NIce, France, and sponsored by the Institute of Teoretical and Applied Informatics of the Polish Academy of Sciences. It also summarizes some of the research contributions of several EU Projects including NEMESYS, GHOST, KONFIDO, SDK4ED and IoTAC, primarily with a cybersecurity and Machine Learning orientation. Thus subjects covered include the cybersecurity of Mobile Networks and of the Internet of Things (IoT), the design of IoT Gateways and their performance, the security of networked health systems that provide health services to individuals across the EU Member states, as well as the issues of energy consumption by ICT which are becoming increasingly important, including in the cybersecurity perspective, as we focus increasingly on climate change and the needed transition towards highly reduced emissions. Many of the techniques and results discussed in this article are based either on Machine Learning (ML) methods, or on methods for the performance modeling and optimization of networked and distributed computer systems.