Diffusion and controlled release characteristics of pH-sensitive poly(2-(dimethyl amino)ethyl methacrylate-co-2-hydroxyethylacrylate) hydrogels

Eswaramma, S.; Rao, K.S.V. Krishna; Rao, Kummara Madhusudana

doi:10.1080/00914037.2015.1074910

Cited by 14 publications

(8 citation statements)

References 41 publications

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“…The pristine TMGA hydrogel spectrum is depicted in Figure 1 B, with peaks observed at 1729.52 cm −1 and 1612.95 for (acid/amide) -C=O stretching vibration. The broad peak for TMG’s -O-H bending vibration was recorded at 1380.95 cm −1 [ 29 , 30 ]. Furthermore, peaks for P-O, P=O, and -C-O-C stretching vibrations emerged at 1216.19 and 1053 cm −1 , confirming the existence of phosphate crosslinker (BMEP).…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Novel Tamarind Gum-co-poly(acrylamidoglycolic acid)-Based pH Responsive Semi-IPN Hydrogels and Their Ag Nanocomposites for Controlled Release of Chemotherapeutics and Inactivation of Multi-Drug-Resistant Bacteria

Nagaraja

Rao

et al. 2021

Gels

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In this paper, novel pH-responsive, semi-interpenetrating polymer hydrogels based on tamarind gum-co-poly(acrylamidoglycolic acid) (TMGA) polymers were synthesized using simple free radical polymerization in the presence of bis[2-(methacryloyloxy)ethyl] phosphate as a crosslinker and potassium persulfate as a initiator. In addition, these hydrogels were used as templates for the green synthesis of silver nanoparticles (13.4 ± 3.6 nm in diameter, TMGA-Ag) by using leaf extract of Teminalia bellirica as a reducing agent. Swelling kinetics and the equilibrium swelling behavior of the TMGA hydrogels were investigated in various pH environments, and the maximum % of equilibrium swelling behavior observed was 2882 ± 1.2. The synthesized hydrogels and silver nanocomposites were characterized via UV, FTIR, XRD, SEM and TEM. TMGA and TMGA-Ag hydrogels were investigated to study the characteristics of drug delivery and antimicrobial study. Doxorubicin hydrochloride, a chemotherapeutic agent successfully encapsulated with maximum encapsulation efficiency, i.e., 69.20 ± 1.2, was used in in vitro release studies in pH physiological and gastric environments at 37 °C. The drug release behavior was examined with kinetic models such as zero-order, first-order, Higuchi, Hixson Crowell and Korsmeyer–Peppas. These release data were best fitted with the Korsemeyer–Peppas transport mechanism, with n = 0.91. The effects of treatment on HCT116 human colon cancer cells were assessed via cell viability and cell cycle analysis. The antimicrobial activity of TMGA-Ag hydrogels was studied against Staphylococcus aureus and Klebsiella pneumonia. Finally, the results demonstrate that TMGA and TMGA-Ag are promising candidates for anti-cancer drug delivery and the inactivation of pathogenic bacteria, respectively.

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Section: Resultsmentioning

confidence: 99%

Synthesis of Novel Tamarind Gum-co-poly(acrylamidoglycolic acid)-Based pH Responsive Semi-IPN Hydrogels and Their Ag Nanocomposites for Controlled Release of Chemotherapeutics and Inactivation of Multi-Drug-Resistant Bacteria

Nagaraja

Rao

et al. 2021

Gels

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“…For each mechanism, diverse factors affect the release kinetics [ 9 , 10 , 11 ]. Among these factors, temperature [ 12 ], initial drug load [ 13 ], circulating flow [ 14 ] pH [ 15 , 16 ], ionic strength, redox and enzymes are, for example, elements whose influence deserves to be studied. In addition, many studies have been conducted to explore the possibilities offered by polymeric biomaterials in regulating drug liberation from stimuli-responsive drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%

“…Mathematical models for the evaluation of drug-release profiles proceed by solving the equations of the involved physical mechanisms [ 14 , 16 ]; and considering the evolution of kinetics [ 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

Development of a Model Based on Physical Mechanisms for the Explanation of Drug Release: Application to Diclofenac Release from Polyurethane Films

et al. 2021

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In this study, we present a method for prediction of the drug-release profile based on the physical mechanisms that can intervene in drug release from a drug-carrier. The application presented here incorporates the effects of drug concentration and Reynolds number defining the circulating flow in the testing vein. The experimental data used relate to the release of diclofenac from samples of non-degradable polyurethane subjected to static and continuous flow. This case includes simultaneously three mechanisms: burst-release, diffusion and osmotic pressure, identified beforehand here as being able to contribute to the drug liberation. For this purpose, authors coded the Sequential Quadratic Programming Algorithm to solve the problem of non-linear optimization. The experimental data used to develop the mathematical model obtained from release studies carried out in water solution at 37 °C, for three concentrations of diclofenac and two water flow rates. We discuss the contribution of mechanisms and kinetics by considering two aforementioned parameters and, following that, we obtain the specific-model and compare the calculated results with the experimental results for the reserved cases. The results showed that drug percentage mostly affect the burst release, however flow rate has affected the osmotic release. In addition, release kinetics of all the mechanisms have increased by increasing the values of two considered parameters.

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“…This is due to their unique capability to change in volume or shape in response to surrounding environmental signals. This stimuli response can either be physical or chemical such as temperature, pH, electric field and enzymes or light (Eswaramma et al, 2016;Koetting et al, 2016;Ozay, 2014).…”

Section: Introductionmentioning

confidence: 99%

A response surface modelling study for sorption of Cu²⁺, Ni²⁺, Zn²⁺ and Cd²⁺ using chemically modified poly(vinylpyrrolidone) and poly(vinylpyrrolidone-co-methylacrylate) hydrogels

Kemik

Ngwabebhoh

Yıldız

2016

Adsorption Science & Technology

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In this present study, response surface methodology was applied for the optimization and evaluation of different heavy-metal sorption processes. Poly(vinylpyrrolidone) and poly(vinylpyrrolidone-comethylacrylate) hydrogels were used as pH-responsive adsorbents to investigate their efficiency in the uptake of Cu 2þ , Ni 2þ , Zn 2þ and Cd 2þ metal ions from aqueous solution in a batch reactor system. The effect of operational parameters such as initial pH and contact time were studied using central composite design. Analysis of variance depicted the central composite design model was significant for Cu 2þ , Ni 2þ , Zn 2þ and Cd 2þ metal ions removal by the investigated hydrogels. A comparison between the model results and experimental data showed that poly(vinylpyrrolidoneco-methylacrylate) possessed higher metal ions binding affinity than poly(vinylpyrrolidone) hydrogel. The heavy-metal ions sorption kinetic well fitted the pseudo second-order kinetic model. Evaluation of the intraparticle diffusion model suggested the sorption process occurred in two phases: surface sorption and intraparticle diffusion. Isothermic results revealed that Freundlich and Temkin isotherms best described the adsorbate-adsorbent interactions. Maximum sorption capacities were observed for Cu 2þ ion and were determined as 86.66 mg/g and 98.53 mg/g for poly(vinylpyrrolidone) and poly(vinylpyrrolidone-co-methylacrylate) hydrogels, respectively.

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Diffusion and controlled release characteristics of pH-sensitive poly(2-(dimethyl amino)ethyl methacrylate-co-2-hydroxyethylacrylate) hydrogels

Cited by 14 publications

References 41 publications

Synthesis of Novel Tamarind Gum-co-poly(acrylamidoglycolic acid)-Based pH Responsive Semi-IPN Hydrogels and Their Ag Nanocomposites for Controlled Release of Chemotherapeutics and Inactivation of Multi-Drug-Resistant Bacteria

Synthesis of Novel Tamarind Gum-co-poly(acrylamidoglycolic acid)-Based pH Responsive Semi-IPN Hydrogels and Their Ag Nanocomposites for Controlled Release of Chemotherapeutics and Inactivation of Multi-Drug-Resistant Bacteria

Development of a Model Based on Physical Mechanisms for the Explanation of Drug Release: Application to Diclofenac Release from Polyurethane Films

A response surface modelling study for sorption of Cu²⁺, Ni²⁺, Zn²⁺ and Cd²⁺ using chemically modified poly(vinylpyrrolidone) and poly(vinylpyrrolidone-co-methylacrylate) hydrogels

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Diffusion and controlled release characteristics of pH-sensitive poly(2-(dimethyl amino)ethyl methacrylate-co-2-hydroxyethylacrylate) hydrogels

Cited by 14 publications

References 41 publications

Synthesis of Novel Tamarind Gum-co-poly(acrylamidoglycolic acid)-Based pH Responsive Semi-IPN Hydrogels and Their Ag Nanocomposites for Controlled Release of Chemotherapeutics and Inactivation of Multi-Drug-Resistant Bacteria

Synthesis of Novel Tamarind Gum-co-poly(acrylamidoglycolic acid)-Based pH Responsive Semi-IPN Hydrogels and Their Ag Nanocomposites for Controlled Release of Chemotherapeutics and Inactivation of Multi-Drug-Resistant Bacteria

Development of a Model Based on Physical Mechanisms for the Explanation of Drug Release: Application to Diclofenac Release from Polyurethane Films

A response surface modelling study for sorption of Cu2+, Ni2+, Zn2+ and Cd2+ using chemically modified poly(vinylpyrrolidone) and poly(vinylpyrrolidone-co-methylacrylate) hydrogels

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A response surface modelling study for sorption of Cu²⁺, Ni²⁺, Zn²⁺ and Cd²⁺ using chemically modified poly(vinylpyrrolidone) and poly(vinylpyrrolidone-co-methylacrylate) hydrogels