DIFFUSION‐IN‐GEL ENZYME‐LINKED IMMUNOSORBENT ASSAY (DIG‐ELISA) FOR DETECTION OF CLASS‐SPECIFIC ANTIBODIES TO <i>ASPERGILLUS FUMIGATUS</i> AND <i>CANDIDA ALBICANS</i>

Lange, Stefan; Nygren, Håkan; Brorson, John‐Erik; Holmberg, Ingrid; Larsson, Peter

doi:10.1111/j.1699-0463.1981.tb02717.x

Acta Pathologica Microbiologica Scandinavica Section C Immunolo

1981

DOI: 10.1111/j.1699-0463.1981.tb02717.x

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DIFFUSION‐IN‐GEL ENZYME‐LINKED IMMUNOSORBENT ASSAY (DIG‐ELISA) FOR DETECTION OF CLASS‐SPECIFIC ANTIBODIES TO ASPERGILLUS FUMIGATUS AND CANDIDA ALBICANS

Stefan Lange¹,

Håkan Nygren

John‐Erik Brorson³

et al.

Abstract: The diffusion‐in‐gel enzyme‐linked immunosorbent assay (DIG‐ELISA) was used to study the specific IgG, IgA and IgM serum antibody response in rabbits immunized with freeze‐pressed cells of Aspergillus fumigatus or Candida albicans. Compared to the conventional double‐diffusion‐in‐gel technique the DIG‐ELISA was found to be more sensitive and equally specific.

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1985

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Experimental pulmonary candidiasis in modified rabbits

Nakamura

1985

Mycopathologia

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Pulmonary lesions induced by an intratracheal inoculation of Candida albicans into rabbits in untreated control, bovine serum albumin (BSA)-sensitized and C. albicans-sensitized groups were examined immunohistochemically to clarify the localization of IgG, IgM and C3. In the control group no inflammatory cells were immunoreactive for IgG and only a few macrophages for IgM and C3, whereas in the BSA- and C. albicans-sensitized groups there were a small number of IgG-positive polymorphonuclear leukocytes and IgM- and C3-positive macrophages in the lesions, the latter group being more prominent. Furthermore, epithelioid granulomatous lesions at the late stage in the C. albicans-sensitized animals showed scattered epithelioid cells containing IgG as well as abundant IgG- and IgM-positive plasma cells. These immunohistochemical results were considered to support the estimation that immune complexes contributed to the modification of fungal lesions in the C. albicans-sensitized hosts, although non-immunological defense mechanisms seemed to be more important in the elimination of the fungus.

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Experimental pulmonary candidiasis in modified rabbits

Nakamura

1985

Mycopathologia

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DIFFUSION‐IN‐GEL ENZYME‐LINKED IMMUNOSORBENT ASSAY (DIG‐ELISA) FOR DETECTION OF CLASS‐SPECIFIC ANTIBODIES TO ASPERGILLUS FUMIGATUS AND CANDIDA ALBICANS

Cited by 1 publication

References 15 publications

Experimental pulmonary candidiasis in modified rabbits

Experimental pulmonary candidiasis in modified rabbits

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