Diffusion-Limited Processes in Hydrogels with Chosen Applications from Drug Delivery to Electronic Components

Lavrentev, Filipp V.; Shilovskikh, Vladimir V.; Alabusheva, Varvara S.; Yurova, Veronika Yu.; Никитина, А. А.; Ulasevich, Sviatlana A.; Skorb, Ekaterina V.

doi:10.3390/molecules28155931

Cited by 19 publications

(3 citation statements)

References 284 publications

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“…48,49 Moreover, stiffer terpolymer matrix could result in lower diffusion coefficients for oxygen, nutrients, and metabolic by products, thus affecting viability. 50,51 Similar results, were observed with other stiff matrices used for T cell encapsulation, including chitosan 30 and alginate-based 32 scaffolds.…”

Section: Cell Viability and Expansionsupporting

confidence: 81%

In vitro encapsulation and expansion of T and CAR-T cells using 3D synthetic thermo-responsive matrices

Lizana-Vasquez,

Mendez-Vega,

Cappabianca

et al. 2024

RSC Adv.

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Section: Cell Viability and Expansionsupporting

confidence: 81%

In vitro encapsulation and expansion of T and CAR-T cells using 3D synthetic thermo-responsive matrices

Lizana-Vasquez,

Mendez-Vega,

Cappabianca

et al. 2024

RSC Adv.

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“…This may be associated with the triggered activity of astrocytes since there was no significant increase in LDH release (Figure 3), thus, there was no significant cell death initiated with LPS treatment. Based on the 3D network structure of hydrogels and their ability to act as a barrier membrane to slow down release 29 may create a supportive encapsulating environment for 3D cultured cells, it is believed that a higher concentration of LPS may be required to trigger astrocyte reactivity in vitro .…”

Section: Resultsmentioning

confidence: 99%

Lithium‐loaded GelMA‐Phosphate glass fibre constructs: Implications for astrocyte response

Keskin‐Erdogan,

Mandakhbayar,

Jin

et al. 2024

J Biomedical Materials Res

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Combinations of different biomaterials with their own advantages as well as functionalization with other components have long been implemented in tissue engineering to improve the performance of the overall material. Biomaterials, particularly hydrogel platforms, have shown great potential for delivering compounds such as drugs, growth factors, and neurotrophic factors, as well as cells, in neural tissue engineering applications. In central the nervous system, astrocyte reactivity and glial scar formation are significant and complex challenges to tackle for neural and functional recovery. GelMA hydrogel‐based tissue constructs have been developed in this study and combined with two different formulations of phosphate glass fibers (PGFs) (with Fe3+ or Ti2+ oxide) to impose physical and mechanical cues for modulating astrocyte cell behavior. This study was also aimed at investigating the effects of lithium‐loaded GelMA‐PGFs hydrogels in alleviating astrocyte reactivity and glial scar formation offering novel perspectives for neural tissue engineering applications. The rationale behind introducing lithium is driven by its long‐proven therapeutic benefits in mental disorders, and neuroprotective and pronounced anti‐inflammatory properties. The optimal concentrations of lithium and LPS were determined in vitro on primary rat astrocytes. Furthermore, qPCR was conducted for gene expression analysis of GFAP and IL‐6 markers on primary astrocytes cultured 3D into GelMA and GelMA‐PGFs hydrogels with and without lithium and in vitro stimulated with LPS for astrocyte reactivity. The results suggest that the combination of bioactive phosphate‐based glass fibers and lithium loading into GelMA structures may impact GFAP expression and early IL‐6 expression. Furthermore, GelMA‐PGFs (Fe) constructs have shown improved performance in modulating glial scarring over GFAP regulation.

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“…While ideally, the hydrogel should absorb humidity from the ambient environment, the prevailing trend is the dominant outward diffusion of water [24]. The diffusion of water molecules out of the blend and the segregation of additives, such as glycerol and fillers, are the main mechanisms of the degradation of the eco-friendly devices fabricated with biopolymer over time [24,45,58]. It is noteworthy that through the regeneration process, the blend tends to expel water from the melted matrix (see red arrows).…”

Section: Regeneration Process Of the Aged Device Through Uptakementioning

confidence: 99%

Regeneration and Long-Term Stability of a Low-Power Eco-Friendly Temperature Sensor Based on a Hydrogel Nanocomposite

Landi,

Pagano,

Granata

et al. 2024

Nanomaterials

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A water-processable and low-cost nanocomposite material, based on gelatin and graphene, has been used to fabricate an environmentally friendly temperature sensor. Demonstrating a temperature-dependent open-circuit voltage between 260 and 310 K, the sensor effectively detects subzero ice formation. Notably, it maintains a constant temperature sensitivity of approximately −19 mV/K over two years, showcasing long-term stability. Experimental evidence demonstrates the efficient regeneration of aged sensors by injecting a few drops of water at a temperature higher than the gelation point of the hydrogel nanocomposite. The real-time monitoring of the electrical characteristics during the hydration reveals the initiation of the regeneration process at the gelation point (~306 K), resulting in a more conductive nanocomposite. These findings, together with a fast response and low power consumption in the range of microwatts, underscore the potential of the eco-friendly sensor for diverse practical applications in temperature monitoring and environmental sensing. Furthermore, the successful regeneration process significantly enhances its sustainability and reusability, making a valuable contribution to environmentally conscious technologies.

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Diffusion-Limited Processes in Hydrogels with Chosen Applications from Drug Delivery to Electronic Components

Cited by 19 publications

References 284 publications

In vitro encapsulation and expansion of T and CAR-T cells using 3D synthetic thermo-responsive matrices

In vitro encapsulation and expansion of T and CAR-T cells using 3D synthetic thermo-responsive matrices

Lithium‐loaded GelMA‐Phosphate glass fibre constructs: Implications for astrocyte response

Regeneration and Long-Term Stability of a Low-Power Eco-Friendly Temperature Sensor Based on a Hydrogel Nanocomposite

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