Diffusion MRI findings of cytomegalovirus-associated ventriculitis: a case report

Seok, Jee Hyun; Ahn, Ki Sung; Park, H J

doi:10.1259/bjr/31561378

Cited by 23 publications

(16 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In normal fetuses, ADC values have been shown to decrease with brain maturation, mostly due to the ongoing process of myelination, while ADC values may either increase or decrease in various fetal and pediatric brain pathologies. Previous publications dealing with the use of DWI in CMV‐infected brains include a case report by Seok et al , which showed reduced ADC values in lesions along the lateral ventricles in an adult brain, and a report by van der Voorn et al , who found elevated ADC values in their pediatric population, and attributed this to extensive tissue damage. Our findings of reduced ADC values in the subcortical white matter as well as in the thalamus, but not in the basal ganglia, pons and cerebellum, are rather intriguing.…”

Section: Discussionmentioning

confidence: 43%

“…Two studies on ADC values in CMV‐infected brains have been published to date: one was a case report that indicated a low ADC value along the ventricular walls of a CMV‐infected 20‐year‐old patient, and the other was a study performed on a pediatric population with congenital CMV infection. Recent work from our department has shown preliminary indications of a decrease in ADC values throughout the CMV‐infected fetal brain.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Region-specific reductions in brain apparent diffusion coefficient in cytomegalovirus-infected fetuses

Gal

Hoffmann

Weisz

et al. 2016

Ultrasound Obstet Gynecol

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 43%

Section: Introductionmentioning

confidence: 99%

Region-specific reductions in brain apparent diffusion coefficient in cytomegalovirus-infected fetuses

Gal

Hoffmann

Weisz

et al. 2016

Ultrasound Obstet Gynecol

View full text Add to dashboard Cite

show abstract

“…Before the onset of CMV CNS disease, all of these cases were diagnosed with 7 recurrent CMV viremia and had received antiviral therapy. Ventriculoencephalitis is the most common form of CMV CNS disease, but it occurs in <1% of all CMV infections [19], and it is found by autopsy in 33% of acquired immunodeficiency syndrome (AIDS) patients [20], but only rarely in patients who receive HSCT.…”

Section: Clonal Expansion Of T Cells In the Skin Is The Hallmark Of Cmentioning

confidence: 99%

“…Because of the nonspecificity of MRI, the diagnosis of CMV ventriculoencephalitis must be confirmed by histological identification of inclusion-bearing cells, the so-called "Owl's eye" cells [19,23,24].…”

Section: Clonal Expansion Of T Cells In the Skin Is The Hallmark Of Cmentioning

confidence: 99%

A fatal case of cytomegalovirus ventriculoencephalitis in a mycosis fungoides patient who received multiple umbilical cord blood cell transplantations

et al. 2012

View full text Add to dashboard Cite

Abstract:Cytomegalovirus (CMV) infection is latent in the majority of adult humans. The reactivation of CMV causes pneumonia and gastrointestinal disease in severely immunosuppressed patients, who consequently suffer very high mortality due to CMV central nervous system disease. We report here a case involving a 28-year-old female patient with mycosis fungoides who underwent umbilical cord blood transplantation three times and developed CMV ventriculoencephalitis. The patient's CMV viremia was successfully preempted with ganciclovir (GCV) as indicated by undetectable CMV antigenemia, but despite this successful treatment, the patient developed CMV ventriculoencephalitis. Foscarnet (FCV) therapy led to a temporary recovery, after which CMV ventriculoencephalitis recurred and the patient died after receiving combination GCV and FCV therapy. Autopsy samples revealed CMV ventriculoencephalitis, as indicated by numerous inclusion-bearing cells (Owl's eye). It is likely that this patient harbored a GCV-resistant CMV strain; however, it was not possible to obtain nucleic acids suitable for use in assessing this possibility.

show abstract

“…However, to our regret, the spinal cord was not collected at necropsy. In humans, ventriculoencephalitis is the most common form of cytomegalovirus infection in the CNS of immunocompromised patients 5 , 6 . One of the members of the Kansai Conference on Toxicologic Pathology (KCTP) has identified a purulent ventriculitis in a Chinchilla cat.…”

Section: Ventriculoencephalitis In a Young Mousementioning

confidence: 99%

Proceedings of the 2013 Joint JSTP/NTP Satellite Symposium

et al. 2013

View full text Add to dashboard Cite

The first joint Japanese Society of Toxicologic Pathology (JSTP) and National Toxicology Program (NTP) Satellite Symposium, entitled “Pathology Potpourri,” was held on January 29th at Okura Frontier Hotel in Tsukuba, Ibaraki, Japan, in advance of the JSTP’s 29th Annual Meeting. The goal of this Symposium was to present current diagnostic pathology or nomenclature issues to the toxicologic pathology community. This article presents summaries of the speakers’ presentations, including diagnostic or nomenclature issues that were presented, select images that were used for audience voting or discussion, and the voting results. Some lesions and topics covered during the symposium include: treatment-related atypical hepatocellular foci of cellular alteration in B6C3F1 mice; purulent ventriculoencephalitis in a young BALB/c mouse; a subcutaneous malignant schwannoma in a RccHan:WIST rat; spontaneous nasal septum hyalinosis/eosinophilic substance in B6C3F1 mice; a rare pancreatic ductal cell adenoma in a young Lewis rat; eosinophilic crystalline pneumonia in a transgenic mouse model; hyaline glomerulopathy in two female ddY mice; treatment-related intrahepatic erythrocytes in B6C3F1 mice; treatment-related subendothelial hepatocytes in B6C3F1 mice; spontaneous thyroid follicular cell vacuolar degeneration in a cynomolgus monkey; congenital hepatic fibrosis in a 1-year-old cat; a spontaneous adenocarcinoma of the middle ear in a young Crl:CD(SD) rat; and finally a series of cases illustrating some differences between cholangiofibrosis and cholangiocarcinoma in Sprague Dawley and F344 rats.

show abstract

Diffusion MRI findings of cytomegalovirus-associated ventriculitis: a case report

Abstract: Cytomegalovirus (CMV) ventriculoencephalitis is a rare but serious potential complication of CMV infection in immunocompromised patients. Characteristic diffusion-weighted imaging findings can be helpful for the diagnosis of CMV ventriculitis, as in this case report.

Cited by 23 publications

References 12 publications

Region-specific reductions in brain apparent diffusion coefficient in cytomegalovirus-infected fetuses

Region-specific reductions in brain apparent diffusion coefficient in cytomegalovirus-infected fetuses

A fatal case of cytomegalovirus ventriculoencephalitis in a mycosis fungoides patient who received multiple umbilical cord blood cell transplantations

Proceedings of the 2013 Joint JSTP/NTP Satellite Symposium

Contact Info

Product

Resources

About