Diffusion of activated ATM explains γH2AX and MDC1 spread beyond the DNA damage site
Georgi Danovski,
Greta Panova,
Bradley Keister
et al.
Abstract:SummaryDuring DNA repair, ATM-induced H2AX histone phosphorylation and MDC1 recruitment spread megabases beyond the damage site. The mechanism underlying this spread remains unclear. To elucidate this step of the DNA damage response, we measured ATM and MDC1 recruitment kinetics at micro-irradiation-induced complex DNA lesions. While MDC1 spreads beyond the damage-induced focus of ATM accumulation, cohesin loader NIPBL and cohesin subunit RAD21 accumulate later than MDC1. Such delayed recruitment suggests that… Show more
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