Diffusion of drugs from hydrogels and liposomes as drug carriers

Pjanović, Rada; Bošković‐Vragolović, Nevenka; Veljković‐Giga, Jelena; Garić‐Grulović, Radmila; Pejanović, Srdjan; Bugarski, Branko

doi:10.1002/jctb.2357

Cited by 32 publications

(21 citation statements)

References 30 publications

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“…To define the effective diffusion coefficients of polyphenols from different particles the diffusion experiments were further analyzed. The effective diffusion coefficients were calculated using Fick's second law (Pjanovic et al, ):

\ln ((), \frac{C_{D}^{0} - C_{R}^{0}}{C_{D} - C_{R}}) = D_{eff} italicβt

where C D and C R are concentrations of polyphenols in donor and receptor compartments, respectively, at time t , while

C_{D}^{0}

and

C_{R}^{0}

are concentrations in the compartments at time t = 0. The effective diffusion coefficient is D eff while geometrical constant is labeled as β and it is specific for diffusion cell and membrane used in the tests.…”

Section: Methodsmentioning

confidence: 99%

Diffusion of polyphenols from alginate, alginate/chitosan, and alginate/inulin particles

Pravilović

Balanč

Djordjević

et al. 2019

J Food Process Engineering

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Thymus serpyllum L (thyme) aqueous extract was encapsulated within three different types of particles. Thus, electrostatic extrusion was applied to obtain alginate, alginate/chitosan, and alginate/inulin particles with encapsulated extract which is known as a rich source of polyphenolic compounds. The effect of admixed chitosan and inulin was evaluated from the point of polyphenols release by using Franz diffusion cell. The alginate/chitosan particles exhibited the effective diffusion coefficient of 1.94·10−9 ·m2 s−1 which was about 2.7 times lower in comparison to that of alginate/inulin particles and about 6.3 times lower than the effective diffusion coefficient of plain alginate particles. Swelling studies also confirmed decreased permeability of composite particles compared to plain alginate particles. In addition, according to the Korsmeyer–Peppas model, the composite particles exhibited anomalous diffusion of polyphenols controlled by molecular diffusion and polymer relaxation. Practical applications The calcium alginate particles are meant for delivery of biologically active compounds in foods with added value. Coating of alginate particles using chitosan has been investigated to control release of encapsulated biologically active compounds, but also as an improver of the particles structure.

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\ln ((), \frac{C_{D}^{0} - C_{R}^{0}}{C_{D} - C_{R}}) = D_{eff} italicβt

where C D and C R are concentrations of polyphenols in donor and receptor compartments, respectively, at time t , while

C_{D}^{0}

and

C_{R}^{0}

Section: Methodsmentioning

confidence: 99%

Diffusion of polyphenols from alginate, alginate/chitosan, and alginate/inulin particles

Pravilović

Balanč

Djordjević

et al. 2019

J Food Process Engineering

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“…Fick's first and second law of diffusion can be applied for explaining the diffusion phenomena. For cylindrical-shaped hydrogels, the integral diffusion at short times is as follows: [33][34][35] …”

Section: Swelling and Diffusion Characteristicsmentioning

confidence: 99%

Swelling, thermal and mechanical properties of NIPAM-based terpolymeric hydrogel

Shekhar¹,

Mukherjee

Sen

2015

Polym. Bull.

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Thermoresponsive hydrogels based on N-isopropylacrylamide, N-tertiary butylacrylamide (NTBA) and methacrylamide (MAAm) have been prepared by free radical copolymerization in water-dioxane mixture. Fourier transform infrared spectroscopy confirmed the presence of all monomers in the hydrogel system. Scanning electron microscopy revealed that the hydrogel having higher amount of NTBA had more smooth structure compared to others. Differential scanning calorimetry results showed that the free and interfacial water decreased but bound water increased with NTBA content in the hydrogel. Dynamic mechanical analysis results revealed increased storage modulus for the hydrogel having higher content of N-tertiarybutylacrylamide. Swelling studies of the hydrogels at different temperatures showed that all samples followed Fickian type of diffusion. The diffusion coefficient increases with increase in MAAm proportion in the hydrogel. The hydrogels were used in concentrating aqueous bovine serum albumin solution. The separation efficiency of hydrogels having higher content of MAAm were found up to 80 % at 5°C but it decreased upon raising the temperature up to 30°C.

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“…At an early stage, (Mt/M  ) < 0.6, according to Fick's second law, the diffusion process in hydrogels may be expressed using the Higuchi kinetic equation as [30,31] :…”

Section: Single Drug Release Kinetics and Diffusion Modelmentioning

confidence: 99%

Dual Drug Release of Triamterene and Aminophylline from Poly (N-Isopropylacrylamide) Hydrogels

Castro

Mosquera

Katime³

2012

Nanomaterials and Nanotechnology

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We used temperature-sensitive poly(Nisopropylacrylamide) hydrogels as drug delivery systems, so changes in body temperature induced by pathogens could act like external stimuli to activate controlled release of the drugs incorporated in the hydrogel. In the distilled water combined release studies, we chose two model drugs: aminophylline and triamterene. The amount of drug released was measured by UV-Vis spectroscopy following the evolution of the absorption peaks of aminophylline (271 nm) and triamterene (365 nm). The maximum release time was greater for triamterene than for aminophylline at 37 ºC, so these time-release profiles enabled the active ingredients to work over different periods of time. By increasing molar mass or solubility of the drug, we observed that the diffusion coefficient decreased. On the contrary, increasing hydrophobicity of the drug leads to a diffusion coefficient increase. The evolution of pore size distribution of hydrogels during loading and releasing was measured by quasi-elastic light scattering and by environmental electronic scanning microscope. When loading and releasing the drugs, the pore size of the hydrogel decreased and increased again without reaching the initial pore size of the hydrogel, respectively. We observed that the greater the concentration of drug loaded into the hydrogel, the greater the reduction in pore size.

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Diffusion of drugs from hydrogels and liposomes as drug carriers

Cited by 32 publications

References 30 publications

Diffusion of polyphenols from alginate, alginate/chitosan, and alginate/inulin particles

Diffusion of polyphenols from alginate, alginate/chitosan, and alginate/inulin particles

Swelling, thermal and mechanical properties of NIPAM-based terpolymeric hydrogel

Dual Drug Release of Triamterene and Aminophylline from Poly (N-Isopropylacrylamide) Hydrogels

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