Diffusion of Nutrients Molecules and Model Drug Carriers Through Mucin Layer Investigated by Magnetic Resonance Imaging with Chemical Shift Resolution

Lafitte, Géraldine; Thuresson, Krister; Söderman, Olle

doi:10.1002/jps.20749

Cited by 18 publications

(8 citation statements)

References 15 publications

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“…Using pulse-field NMR, Gibbs et al was able to confirm concentration-dependent diffusion of 19F-Ovalbumin through both solution and porous media[88]. Lafitte et al recently showed diffusion of ethanol and glucose through mucin gel, in a setup similar to top-down capillary tube one dimensional diffusion model[89, 90] This technology is limited, however, to solute or tracers with strong paramagnetic groups.…”

Section: Measuring Diffusion Coefficients: Materials Methods and mentioning

confidence: 99%

Mathematical modeling of molecular diffusion through mucus

Saltzman

2009

Advanced Drug Delivery Reviews

108

114

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The rate of molecular transport through the mucus gel can be an important determinant of efficacy for therapeutic agents delivered by oral, intranasal, intravaginal/rectal, and intraocular routes. Transport through mucus can be described by mathematical models based on principles of physical chemistry and known characteristics of the mucus gel, its constituents, and of the drug itself. In this paper, we review mathematical models of molecular diffusion in mucus, as well as the techniques commonly used to measure diffusion of solutes in the mucus gel, mucus gel mimics, and mucosal epithelia.

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Section: Measuring Diffusion Coefficients: Materials Methods and mentioning

confidence: 99%

Mathematical modeling of molecular diffusion through mucus

Saltzman

2009

Advanced Drug Delivery Reviews

108

114

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“…In addition, it was suggested that the micelles can penetrate the mucus gel layer. 115,116) After passing through the rate-limiting layer, the drug can be released from the bile micelles and quickly penetrate the epithelial cellular membrane. Therefore, the micelle incorporated drug molecule may be bioavailable to some extent.…”

Section: Ešective Concentrationmentioning

confidence: 99%

Solubility and Dissolution Profile Assessment in Drug Discovery

Sugano

Okazaki

Sugimoto

et al. 2007

Drug Metabolism and Pharmacokinetics

183

142

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The purposes of the review are to: a) Provide a comprehensible introduction of the-state-of-the-art sciences of solubility and dissolution, b) introduce typical technologies to assess solubility and dissolution, and c) propose the best practice strategy. The theories of solubility and dissolution required in drug discovery were reviewed especially from the view point of oral absorption. The physiological conditions in the gastrointestinal fluid in humans and animals were then briefly summarized. Technologies to assess solubility and dissolution in drug discovery were then introduced. Recently, these technologies have been improved by the laboratory automation and computational technologies. Finally, the strategies to apply these technologies for a drug discovery project were discussed.

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“…The transport of a bioactive may be inhibited if it is present in a form that is too large to penetrate through the pores (≈ 400 nm) or that is strongly attracted to the hydrogel network (e.g., through electrostatic or hydrophobic attraction) (Ensign, Cone, & Hanes, 2012). The transport of hydrophobic bioactives across the mucus layer may therefore be facilitated by using excipient emulsions that generate small mixed micelles in the GIT that easily penetrate through this hydrogel (Lafitte, Thuresson, & Soderman, 2007).…”

Section: Absorptionmentioning

confidence: 99%

Boosting the bioavailability of hydrophobic nutrients, vitamins, and nutraceuticals in natural products using excipient emulsions

McClements

Saliva-Trujillo

Zhang

et al. 2016

Food Research International

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Many highly hydrophobic bioactives, such as non-polar nutrients, nutraceuticals, and vitamins, have a relatively low or variable oral bioavailability. The poor bioavailability profile of these bioactives may be due to limited bioaccessibility, poor absorption, and/or chemical transformation within the gastrointestinal tract (GIT). The bioavailability of hydrophobic bioactives can be improved using specially designed oil-in-water emulsions consisting of lipid droplets dispersed within an aqueous phase. The bioactives may be isolated from their natural environment and then incorporated into the lipid phase of emulsion-based delivery systems. Alternatively, the bioactives may be left in their natural environment (e.g., fruits or vegetables), and then ingested with emulsion-based excipient systems. An excipient emulsion may have no inherent health benefits itself, but it boosts the biological activity of bioactive ingredients co-ingested with it by altering their bioaccessibility, absorption, and/or chemical transformation. This review discusses the design and fabrication of excipient emulsions, and gives some examples of recent research that demonstrates their potential efficacy for improving the bioavailability of hydrophobic bioactives. The concept of excipient emulsions could be used to formulate emulsion-based food products (such as excipient sauces, dressings, dips, creams, or yogurts) specifically designed to increase the bioavailability of bioactive agents in natural foods, such as fruits and vegetables.

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Diffusion of Nutrients Molecules and Model Drug Carriers Through Mucin Layer Investigated by Magnetic Resonance Imaging with Chemical Shift Resolution

Cited by 18 publications

References 15 publications

Mathematical modeling of molecular diffusion through mucus

Mathematical modeling of molecular diffusion through mucus

Solubility and Dissolution Profile Assessment in Drug Discovery

Boosting the bioavailability of hydrophobic nutrients, vitamins, and nutraceuticals in natural products using excipient emulsions

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