We consider the Cauchy problem of the semilinear wave equation with a damping termwhere p > 1 and the coefficient of the damping term has the formIn particular, we mainly consider the cases α < 0, β = 0 or α < 0, β = 1, which imply α + β < 1, namely, the damping is spatially increasing and effective. Our aim is to prove that the critical exponent is given byThis shows that the critical exponent is the same as that of the corresponding parabolic equationThe global existence part is proved by a weighted energy estimates with an exponential-type weight function and a special case of the Caffarelli-Kohn-Nirenberg inequality. The blow-up part is proved by a test-function method introduced by Ikeda and Sobajima [15]. We also give an upper estimate of the lifespan.where N ≥ 1, u = u(t, x) is a real-valued unknown function, ε is a small positive parameter, u 0 , u 1 are given initial data, p > 1, and the coefficient of the damping term has the form c(t, x) = a(x)b(t) = a 0 x −α (1 + t) −β , (1.2)