Diffusion Tensor Imaging Demonstrates Fiber Impairment in Susac Syndrome

Diagnostic criteria for Susac syndrome

“…Although showing a very characteristic pattern in voxel-based group-level analyses,17 DTI was not chosen as a diagnostic criterion because the elaborated method is restricted to specialised centres. The same limitation holds true for the innovative technique of ultrahigh field MRI at 7 Tesla (7T) 18.…”

Nerve fiber impairment of anterior thalamocortical circuitry in juvenile myoclonic epilepsy

“…12 It has been reported that neuropsychological deficits in neurologic patients correlate better with alterations of WM architecture revealed by DTI relative to structural lesions determined using conventional MRI. 13 The purpose of this study was to investigate alterations in the integrity of WM architecture in patients with JME in comparison to healthy controls and patients with cryptogenic partial epilepsy (CPE) using DTI. Furthermore, we also investigated the influence of various clinical factors on white matter integrity in patients with JME, including epilepsy duration, frequency of seizures, age at onset, and duration of anticonvulsant therapy.…”

Neuroimaging in Susac's syndrome: Focus on DTI

“…The signal to the frontal cortex was reduced as well. Compared to conventional MR images showing small lesions in the white and grey matter, this disruption of fiber impairment seems to better reflect the severe psychopathic deficits that occur in many patients [13].…”