Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid deposition

Song, Sheng‐Kwei; Kim, Joong Hee; Lin, Shiow-Jiuan; Brendza, Robert P.; Holtzman, David M.

doi:10.1016/j.nbd.2003.12.003

Cited by 163 publications

(105 citation statements)

References 46 publications

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“…Because in vivo mouse DTIs have been successfully performed recently (Song et al, 2002(Song et al, , 2004, it is of great interest to know whether our findings are compatible with in vivo studies. Although we do not have data directly comparing ex vivo and in vivo results from the same animals, past studies suggest that FA is well preserved in postmortem samples (Sun et al, 2003(Sun et al, , 2005.…”

Section: Discussionsupporting

confidence: 56%

Quantitative Cortical Mapping of Fractional Anisotropy in Developing Rat Brains

Huang¹,

Yamamoto²,

Hossain³

et al. 2008

J. Neurosci.

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Cortical development is associated with a series of events that involve axon and dendrite growth and synaptic formation. Although these developmental processes have been investigated in detail with histology, three-dimensional and quantitative imaging methods for rodent brains may be useful for genetic and pharmacological studies in which cortical developmental abnormalities are suspected. It has been shown that diffusion tensor imaging (DTI) can delineate the columnar organization of the fetal and early neonatal cortex based on a high degree of diffusion anisotropy along the columnar structures. This anisotropy is known to decrease during brain development. In this study, we applied DTI to developing rat brains at five developmental stages, postnatal days 0, 3, 7, 11 and 19, and used diffusion anisotropy as an index to characterize the structural change. Statistical analysis reveals four distinctive cortical areas that demonstrate a characteristic time course of anisotropy loss. This method may provide a means to delineate specific cortical areas and a quantitative method to detect abnormalities in cortical development in rodent pathological models.

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Section: Discussionsupporting

confidence: 56%

Quantitative Cortical Mapping of Fractional Anisotropy in Developing Rat Brains

Huang¹,

Yamamoto²,

Hossain³

et al. 2008

J. Neurosci.

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“…31 Song and colleagues observed white matter alterations in the brains of PDAPP mouse model of AD using diffusion tensor imaging (DTI) with the manifestation of amyloid plaque pathology. 32 Another study revealed decreased brain matter volume in the corpus callosum of PDAPP mice before the appearance of plaques. 33 Gotz and colleagues discussed the presence of axonopathy and accumulation of both intracellular and extracellular A␤ in white matter of Tg2576 mouse model.…”

Section: Discussionmentioning

confidence: 99%

Early Oligodendrocyte/Myelin Pathology in Alzheimer's Disease Mice Constitutes a Novel Therapeutic Target

Desai

Mastrangelo

Ryan

et al. 2010

The American Journal of Pathology

190

173

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The detection of myelin disruptions in Alzheimer's disease (AD)-affected brain raises the possibility that oligodendrocytes undergo pathophysiological assault over the protracted course of this neurodegenerative disease. Oligodendrocyte compromise arising from direct toxic effects imparted by pathological amyloid-␤ peptides and/or through signals derived from degenerating neurons could play an important role in the disease process. We previously demonstrated that 3؋Tg-AD mice, which harbor the human amyloid precursor protein Swedish mutant transgene, presenilin knock-in mutation, and tau P301L mutant transgene, exhibit significant alterations in overall myelination patterns and oligodendrocyte status at time points preceding the appearance of amyloid and tau pathology. Herein, we demonstrate that A␤ 1-42 leads to increased caspase-3 expression and apoptotic cell death of both nondifferentiated and differentiated mouse oligodendrocyte precursor (mOP) cells in vitro. Through use of a recombinant adeno-associated virus serotype-2 (rAAV2) vector expressing an A␤ 1-42 -specific intracellular antibody (intrabody), oligodendrocyte and myelin marker expression, as well as myelin integrity, were restored in the vector-infused brain regions of 3؋Tg-AD mice. Overall, this work provides further insights into the impact of A␤ 1-42 -mediated toxicity on the temporal and spatial progression of subtle myelin disruption during the early presymptomatic stages of AD and may help to validate new therapeutic options designed to avert these early impairments.

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“…FA did not account for those contributions because the dendrites are only partially coherently organized and the axons are not homogeneously distributed and might be myelinated or unmyelinated in gray matter. 22,23 When overlaid to the statistical parametric mapping-integrated T1 template, the changes were seen mostly within the subcortical white matter areas with a small portion of voxels overlapped with cortex. Because it is difficult to separate the white matter and gray matter with DTI contrast, the results are elaborated with "gyrus" (which contain both subcortical white matter and cortex) as its units.…”

Section: Discussionmentioning

confidence: 99%

DTI Analysis of Presbycusis Using Voxel-Based Analysis

Ma¹,

Li²,

Gao³

et al. 2016

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Presbycusis is the most common sensory deficit in the aging population. A recent study reported using a DTI-based tractography technique to identify a lack of integrity in a portion of the auditory pathway in patients with presbycusis. The aim of our study was to investigate the white matter pathology of patients with presbycusis by using a voxel-based analysis that is highly sensitive to local intensity changes in DTI data.

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Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid deposition

Cited by 163 publications

References 46 publications

Quantitative Cortical Mapping of Fractional Anisotropy in Developing Rat Brains

Quantitative Cortical Mapping of Fractional Anisotropy in Developing Rat Brains

Early Oligodendrocyte/Myelin Pathology in Alzheimer's Disease Mice Constitutes a Novel Therapeutic Target

DTI Analysis of Presbycusis Using Voxel-Based Analysis

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