Diffusion tensor imaging in abdominal organs

Lanzman, Rotem S.; Wittsack, Hans‐Jörg

doi:10.1002/nbm.3434

Cited by 18 publications

(13 citation statements)

References 135 publications

(204 reference statements)

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“…Taouli et al showed that diffusion is isotropic in the liver parenchyma ( 20 ), whereas Tosun et al observed a significant nonzero value for fractional anisotropy (FA) in the liver (average FA, 0.48) using diffusion tensor imaging (DTI) measurements, indicative of substantial anisotropy in the liver parenchyma ( 21 ). Kidney diffusion anisotropy has been studied quite extensively with DTI, showing significant anisotropy, particularly in the renal medulla (FA range: 0.24–0.57 in the medulla compared with 0.13–0.31 in the cortex) ( 22 ). Diffusion in the pancreas has also been shown to be anisotropic (mean FA, 0.38) ( 23 ).…”

Section: Discussionmentioning

confidence: 99%

Comparison between 3-Scan Trace and Diagonal Body Diffusion-Weighted Imaging Acquisitions: A Phantom and Volunteer Study

et al. 2016

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Diagonal diffusion-weighted imaging (dDWI) uses simultaneous maximized application of 3 orthogonal gradient systems as opposed to sequential acquisition in 3 directions in conventional 3-scan trace DWI (tDWI). Several theoretical advantages of dDWI vs. tDWI include reduced artifacts and increased sharpness. We compared apparent diffusion coefficient (ADC) quantification and image quality between monopolar dDWI and tDWI in a dedicated diffusion phantom (b = 0/500/900/2000 s/mm 2 ) and in the abdomen (b = 50/400/800 s/mm 2 ) and pelvis (b = 50/1000/1600 s/mm 2 ) of 2 male volunteers at 1.5 T and 3.0 T. Phantom estimated signal-to-noise ratio (eSNR) was also measured. Two independent observers assessed the image quality on a 5-point scale. In the phantom, image quality was similar between tDWI and dDWI, with equivalent ADC quantification (mean coefficient of variation [CV] between sequences: 1.4% ± 1.2% at 1.5 T and 0.7% ± 0.7% at 3.0 T). Phantom eSNR was similar for both tDWI and dDWI, except for a significantly lower eSNR for b900 of dDWI at 3.0 T (P = .006). In the volunteers, the CV values between tDWI and dDWI were higher than those in the phantom (CV range: abdominal organs, 1.3%-13.3%; pelvic organs, 0.6%-5.7%). A trend toward significant better image quality for dDWI compared with tDWI was observed for b800 (abdomen) at 3.0 T and for b1000 and b1600 (pelvis) at 1.5 T (P = .063 to .066). Our data suggest that dDWI may provide better image quality than tDWI without affecting ADC quantification, needing confirmation in a future clinical study.

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Section: Discussionmentioning

confidence: 99%

Comparison between 3-Scan Trace and Diagonal Body Diffusion-Weighted Imaging Acquisitions: A Phantom and Volunteer Study

et al. 2016

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“…Nevertheless, simple DWI experiments using two b ‐values assume monoexponential SI decay and yield an averaged ADC over three orthogonal directions, disregarding the non‐monoexponential contribution of the fast “pseudo‐diffusion” component, caused by microperfusion, as well as directional dependency (anisotropy) of the diffusion processes in the structured tissue. In recent years technical advances have improved the acquisition of abdominal DW images in terms of quality and speed, allowing the investigation of advanced diffusion MRI modeling in abdominal studies, including in the pancreas. These advanced approaches consist of further sampling and analysis frameworks that capitalize on tissue qualities such as microstructural anisotropy and microvascularity, in the form of diffusion tensor imaging (DTI), which extends the spatial information acquired, and the intravoxel incoherent motion (IVIM) model, which extends the number of diffusion weightings, allowing compartmental separation.…”

Section: Diffusion Mri Of the Pancreasmentioning

confidence: 99%

Modifications of pancreatic diffusion MRI by tissue characteristics: what are we weighting for?

Nissan

2017

NMR in Biomedicine

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Diffusion-weighted imaging holds the potential to improve the diagnosis and biological characterization of pancreatic disease, and in particular pancreatic cancer, which exhibits decreased values of the apparent diffusion coefficient (ADC). Yet, variable and overlapping ADC values have been reported for the healthy and the pathological pancreas, including for cancer and other benign conditions. This controversy reflects the complexity of probing the water-diffusion process in the pancreas, which is dependent upon multiple biological factors within this organ's unique physiological environment. In recent years, extensive studies have investigated the correlation between tissue properties including cellularity, vascularity, fibrosis, secretion and microstructure and pancreatic diffusivity. Understanding how the various physiological and pathological features and the underlying functional processes affect the diffusion measurement may serve to optimize the method for improved diagnostic gain. Therefore, the aim of the present review article is to elucidate the relationship between pancreatic tissue characteristics and diffusion MRI measurement.

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“…Mainly used in neuroimaging studies for the characterization of brain white matter tracts 6 , DTI has been recently applied to different intra-abdominal organs 7 including prostate 8–10 , liver 11,12 and kidney 13,14 . DTI is particularly suitable for kidney studies due to well-defined structural organization.…”

Section: Introductionmentioning

confidence: 99%

Diffusion Tensor Imaging of the Kidney: Design and Evaluation of a Reliable Processing Pipeline

Borrelli

Cavaliere

Basso

et al. 2019

Sci Rep

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Diffusion tensor imaging (DTI) is particularly suitable for kidney studies due to tubules, collector ducts and blood vessels in the medulla that produce spatially restricted diffusion of water molecules, thus reflecting the high grade of anisotropy detectable by DTI. Kidney DTI is still a challenging technique where the off-resonance susceptibility artefacts and subject motion can severely affect the reproducibility of results. The aim of this study is to design a reliable processing pipeline by assessing different image processing approaches in terms of reproducibility and image artefacts correction. The results of four different processing pipelines ( eddy : correction of eddy-currents and motion between DTI volume; eddy - s2v : eddy and within DTI volume motion correction; topup : eddy and geometric distortion correction; topup - s2v : topup and within DTI volume motion correction) are compared in terms of reproducibility by test-retest analysis in 14 healthy subjects. Within-subject coefficient of variation (wsCV) and intra-class correlation coefficient (ICC) are measured to assess the reproducibility and Dice similarity index is evaluated for the spatial alignment between DTI and anatomical images. Topup - s2v pipeline provides highest reproducibility (wsCV = 0.053, ICC = 0.814) and best correction of image distortion (Dice = 0.83). This study definitely provides a recipe for data processing, enabling for a clinical suitability of kidney DTI.

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Diffusion tensor imaging in abdominal organs

Cited by 18 publications

References 135 publications

Comparison between 3-Scan Trace and Diagonal Body Diffusion-Weighted Imaging Acquisitions: A Phantom and Volunteer Study

Comparison between 3-Scan Trace and Diagonal Body Diffusion-Weighted Imaging Acquisitions: A Phantom and Volunteer Study

Modifications of pancreatic diffusion MRI by tissue characteristics: what are we weighting for?

Diffusion Tensor Imaging of the Kidney: Design and Evaluation of a Reliable Processing Pipeline

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