Diffusion tensor imaging in spinal cord injury

Kamble, Ravindra B; Venkataramana, N. K.; Naik, Arun L; Rao, Shailesh V

doi:10.4103/0971-3026.85372

Cited by 27 publications

(21 citation statements)

References 10 publications

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“…By comparing FA values of the whole cord section, at 12, 3, 6 and 9 o'clock below the most affected disc with FA values opposite to normal cord level (C2-C2/3), we found highly significant FA value reduction with P value = 0.001. This matches with Kamble et al [13] who found that FA values are decreased below the site of injury, likely due to Wallerian degeneration.…”

Section: Discussionsupporting

confidence: 91%

MR diffusion tensor imaging of the spinal cord: can it help in early detection of cervical spondylotic myelopathy and assessment of its severity?

Hassan

Assad²,

Belal³

2019

Egypt J Radiol Nucl Med

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Background: The aim of this study is to evaluate the potential application of MR diffusion tensor imaging (with calculation of fractional anisotropy (FA) values) in assessment of the spondylotic cervical spinal canal compromise and comparison with the information issued from conventional MR sequences for early detection of cervical spondylotic myelopathy (CSM). Thirty patients (11 males and 19 females) were included in this study; age ranged from 22 to 70 years (mean age = 44). All patients had conventional and diffusion tensor imaging (DTI) examinations of the cervical spine for detection and assessment of degree of cervical cord myelopathy. FA values of the whole cord circumference and at 3, 6, 9, 12 o'clock positions of the normal cord (opposite to C2), opposite to the most affected disc, and below the level of the most affected disc were measured. Results: High statistically significant P values were obtained when comparing the FA values of the normal cord with the cord opposite to the most affected disc, the normal cord with the cord below the affected disc and the cord at the level of the most affected disc with the cord below the level of the most affected disc. Conclusions: DTI of the cervical spinal cord with FA measurement in patients with cervical spondylosis helps in early detection of cervical cord compressive myelopathy prior to appearance of changes in conventional MRI, which can improve the clinical outcome and help in treatment plans.

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Section: Discussionsupporting

confidence: 91%

MR diffusion tensor imaging of the spinal cord: can it help in early detection of cervical spondylotic myelopathy and assessment of its severity?

Hassan

Assad²,

Belal³

2019

Egypt J Radiol Nucl Med

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“…Previous studies [34][35][36] about CSM offer a comparative analysis between the CSC DTI parameters according to age and lesion site, but without considering the combined influence of age and segments. The same is true for MRI studies of spinal cord trauma [37,38]. In the future, we should fully consider these factors to avoid the interference of confounding factors.…”

Section: Discussionmentioning

confidence: 88%

Age-related changes of the diffusion tensor imaging parameters of the normal cervical spinal cord

Wang

Song

Fan

et al. 2014

European Journal of Radiology

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“…Recent studies of the spinal cord indicate the large disagreement in the applied number of directions. [25][26][27][28] When establishing a DTI protocol for clinical implementation, it is critical to consider the number of gradient directions of the DTI scheme in terms of the overall goal of the study. Consistent with other studies, we observed that a scan time equivalent gradient scheme of 6 directions is significantly worse than a gradient scheme of 15 or 32 directions in estimation for DFA, 15 but we further reveal that these trends are also observed for DAD and DRD.…”

Section: Discussionmentioning

confidence: 99%

Quantifying the impact of underlying measurement error on cervical spinal cord diffusion tensor imaging at 3T

Smith

Dethrage

et al. 2016

J. Magn. Reson. Imaging

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Purpose To empirically characterize and quantify the impact of gradient weighting schemes on the appearance and fidelity of diffusion tensor imaging of the human spinal cord in vivo in clinically relevant scan time equivalents (STE). Materials & Methods In five healthy controls at 3 tesla, we evaluated test-retest reproducibility and performed voxel-wise analysis of DTI-derived indices (fractional anisotropy (FA), mean (MD), axial (AD) and radial (RD) diffusivity) in the cervical spinal cord to assess spatial dependencies of measurement error and differences across three different sampling schemes (6, 15, and 32 directions) at STE of 4.5, 9 and 18 minutes. A subjective assessment was also performed. Results With six directions, column-specific errors are highest (effect size=2.9%, 4.4%, 7.2% for FA in dorsal column, lateral column, and gray matter) and different than the 15-direction scheme (p<0.05). STE sequences with 15 and 32 directions exhibited small differences in error (p>0.05). For FA and AD, measurement errors are prevalent in gray matter, while partial volume effects with CSF heavily influence RD. Measurement errors decreased with increasing scan time (p<0.01), albeit with diminishing returns at scan times longer than 9 minutes (p<0.05). Conclusion A 15-direction scheme of 9 minutes yields measurements of the cervical spinal cord with low error.

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Diffusion tensor imaging in spinal cord injury

Cited by 27 publications

References 10 publications

MR diffusion tensor imaging of the spinal cord: can it help in early detection of cervical spondylotic myelopathy and assessment of its severity?

MR diffusion tensor imaging of the spinal cord: can it help in early detection of cervical spondylotic myelopathy and assessment of its severity?

Age-related changes of the diffusion tensor imaging parameters of the normal cervical spinal cord

Quantifying the impact of underlying measurement error on cervical spinal cord diffusion tensor imaging at 3T

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