Diffusion tensor imaging of cysts, hemangiomas, and metastases of the liver

Ertürk, Şükrü Mehmet; Ichikawa, Tomoaki; Kaya, Emel; Yapici, Ozge; Özel, Alper; Mahmutoğlu, Abdullah Soydan; Başak, Muzaffer

doi:10.1177/0284185113504916

Cited by 24 publications

(21 citation statements)

References 14 publications

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“…It was reported that the positive correlation of the FA value with tumour cellularity, that is higher FA, was associated with higher tumour cellularity. 18,[22][23][24] In agreement with previous studies in other organs, our results showed that malignant parotid tumours had higher FA values than benign tumours. In our study, there was a significant difference in the FA values not only between benign and malignant tumours but also between pleomorphic adenomas and adenolymphomas.…”

Section: Discussionsupporting

confidence: 92%

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Application of DTI and ARFI imaging in differential diagnosis of parotid tumours

Yu¹,

Du²,

Lu³

et al. 2016

Dentomaxillofacial Radiology

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Objectives: To explore the utility of diffusion tensor imaging (DTI) and acoustic radiation force impulse (ARFI) imaging in the diagnosis of parotid tumours. Methods: 51 patients with parotid tumours were examined with DTI on 3.0-T MRI and ARFI imaging on an ultrasound scanner before surgery. Values of apparent diffusion coefficient (ADC), fractional anisotropy (FA) and shear-wave velocity (SWV) were calculated and analyzed with independent samples Wilcoxon-Mann-Whitney test. Cut-off values, sensitivity and specificity were calculated with receiver-operating characteristic (ROC) curve analysis. The value of combination was calculated through parallel test for the cut-off value of ADC, FA and SWV (combination 5 0 or 1); then, ROC analysis was performed with pathological results as the gold standard to calculate the sensitivity and specificity for the combination of the three parameters distinguishing benign and malignant parotid tumours. Pathological diagnosis for every patient was made post-operatively from the tumour tissue taken during operation. Results: There was a significant difference between benign and malignant tumours in the values of ADC, FA and SWV (p 5 0.032, p 5 0.011 and p , 0.0001); a significant difference in the values was also found between pleomorphic adenoma and malignant tumour (p 5 0.0012, p , 0.0001 and p 5 0.0002). The diagnosis cut-off points between benign and malignant tumours for ADC, FA and SWV were 1.02 3 10 23 mm 2 s 21 , 0.24 and 2.76 m s 21 , respectively; the sensitivity for ADC, FA and SWV was 87.50, 62.50 and 68.75%; the specificity was 45.71, 82.86 and 97.14%. Analysis of the combination of the three parameters increased the sensitivity, specificity, Youden index and area under the ROC curve compared with analysis of each parameter alone for distinguishing benign and malignant tumours.

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Section: Discussionsupporting

confidence: 92%

“…16,17 The FA or ADC value has a strong correlation with cell density, 18 and malignant tumours usually have a reduced ADC value and an elevated FA value. 19,20 While DTI is widely applied in multiple organs, 18,[21][22][23][24] its application, particularly the FA value in parotid tumours, is rarely reported.…”

Section: Introductionmentioning

confidence: 99%

Application of DTI and ARFI imaging in differential diagnosis of parotid tumours

Yu¹,

Du²,

Lu³

et al. 2016

Dentomaxillofacial Radiology

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“…Diffusion MRI, particularly DWI, is increasingly used in routine abdominal MRI protocols [5], while the apparent diffusion coefficient (ADC) calculated from DWI has been used to reveal quantitative molecular diffusion. However, DWI merely provides an average ADC over three orthogonal directions, disregarding the anisotropy of tissue structure [10, 11]. It is well known that pancreas is an anisotropic endocrine organ with plenty of vascular supply, as well as complicated anatomy and physiological features [12–14].…”

Section: Introductionmentioning

confidence: 99%

Preliminary Study of MR Diffusion Tensor Imaging of Pancreas for the Diagnosis of Acute Pancreatitis

Zhuang

Zhang

et al. 2016

PLoS ONE

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ObjectivesTo evaluate the feasibility of differentiating between acute pancreatitis (AP) and healthy pancreas using diffusion tensor imaging (DTI) and correlate apparent diffusion coefficient (ADC) /fractional anisotropy (FA) values with the severity of AP.Material and Methods66 patients diagnosed with AP and 20 normal controls (NC) underwent DTI sequences and routine pancreatic MR sequences on a 3.0T MRI scanner. Average ADC and FA values of the pancreatic were measured. Differences of FA and ADC values between the AP group and the NC group with AP and healthy pancreas were compared by two-sample independent t-test. The severity of AP on MRI was classified into subgroups using MR severity index (MRSI), where the mean FA and ADC values were calculated. Relationship among the FA values, ADC values and MRSI were analyzed using Spearman's rank correlation coefficients.ResultsThe pancreatic mean ADC value in the AP group (1.68 ± 0.45×10−3mm2/s) was significantly lower than in the NC group (2.09 ± 0.55×10−3mm2/s) (P = 0.02); the same as mean FA value (0.39 ± 0.23 vs 0.54 ± 0.12, P = 0.00). In the subgroup analysis, the pancreatic ADC and FA value of edema AP patients was significantly higher than necrosis AP patients with P = 0.000 and P = 0.001respectively. In addition, as severity of pancreatitis increased according to MRSI, lower pancreatic ADC (r = -0.635) and FA value (r = -0.654) were noted.ConclusionBoth FA and ADC value from DTI can be used to differentiate AP patients from NC. Both ADC and FA value of pancreas have a negative correlation with the severity of AP.

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“…Diffusion weighted (DWI) MRI is an imaging tool which has its origin in the field of neuroradiology, but has been introduced to abdominal imaging in the last decade (9)(10)(11). DWI allows for characterization of biological tissue on the basis of diffusion of water molecules, which is quantified by the apparent diffusion coefficient (ADC).…”

Section: Introductionmentioning

confidence: 99%

Diffusion-weighted imaging during MR-guided radiofrequency ablation of hepatic malignancies: analysis of immediate pre- and post-ablative diffusion characteristics

et al. 2015

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Diffusion tensor imaging of cysts, hemangiomas, and metastases of the liver

Abstract: Fa values may play a supportive role in the imaging of liver lesions. Whereas metastases tend to have low ADCs and high Fa values, cysts have high ADCs and low Fa values and hemangiomas have high ADCs and high Fa values.

Cited by 24 publications

References 14 publications

Application of DTI and ARFI imaging in differential diagnosis of parotid tumours

Application of DTI and ARFI imaging in differential diagnosis of parotid tumours

Preliminary Study of MR Diffusion Tensor Imaging of Pancreas for the Diagnosis of Acute Pancreatitis

Diffusion-weighted imaging during MR-guided radiofrequency ablation of hepatic malignancies: analysis of immediate pre- and post-ablative diffusion characteristics

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