Diffusion-Tensor Imaging of Thigh Muscles in Duchenne Muscular Dystrophy: Correlation of Apparent Diffusion Coefficient and Fractional Anisotropy Values With Fatty Infiltration

Abstract

Damage to the thigh muscles in patients with DMD can be detected by ADC and FA values using DTI. DTI can be used to assess the severity of the disease.

Advancements in magnetic resonance imaging‐based biomarkers for muscular dystrophy

“…In a similar way, DTI has been used to measure the organization of muscle, which also consists of longitudinally oriented groups of fibers. Early work on DTI in muscular dystrophy indicates that perturbations in fiber organization can be detected in DMD and limb‐girdle muscular dystrophies …”

“…Early work on DTI in muscular dystrophy indicates that perturbations in fiber organization can be detected in DMD and limb-girdle muscular dystrophies. [73][74][75]…”

Multiparametric quantitative MRI assessment of thigh muscles in limb‐girdle muscular dystrophy 2A and 2B

“…Quantitative MRI (qMRI) techniques (in particular fat quantification with Dixon sequences) have been applied mostly to dystrophinopathies (Duchenne and Becker muscular dystrophy), while very few or no data are available for other, more rare, muscular inherited disorders like LGMDs …”

“…12 Quantitative MRI (qMRI) techniques (in particular fat quantification with Dixon sequences) have been applied mostly to dystrophinopathies (Duchenne and Becker muscular dystrophy), while very few or no data are available for other, more rare, muscular inherited disorders like LGMDs. 5,11,[13][14][15][16][17] In this study, we applied the above-mentioned qMRI techniques to patients affected by LGMD2A and LGMD2B, which represent the most frequent forms of LGMD in the Italian population. 18 The aims of this work were (i) the quantification of the structural modifications occurring in the thigh muscles, (ii) the identification of (potentially) different patterns of degeneration between the 2 disorders and in different muscular compartments of the thigh, (iii) the identification of MR-derived disease markers correlating with clinical parameters of muscular strength and function.…”

Texture as an imaging biomarker for disease severity in golden retriever muscular dystrophy

“…Going back to early morphologic papers and extending to correlative MRI‐histopathologic studies, fat‐infiltration has not been observed at similar levels in GRMD dogs. Furthermore, clinical studies demonstrated different fractional anisotropy (FA), apparent diffusion coefficient (ADC), and mean diffusivity (MD) measurements between DMD and healthy patients. FA is negatively correlated with muscle strength but positively correlated with age and fat infiltration, while ADC is positively correlated with muscle strength but negatively correlated with age and fat infiltration .…”