Diffusion tensor imaging reveals regional differences in the cervical spinal cord in amyotrophic lateral sclerosis

Nair, Govind; Carew, John D.; Usher, Sharon; Lu, Debbie; Hu, Xiaoping; Benatar, Michael

doi:10.1016/j.neuroimage.2010.06.060

Cited by 80 publications

(70 citation statements)

References 37 publications

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“…ROIs were defined manually; nonetheless, results showed good reliability across two separate raters [19,22]. Furthermore, our findings agree with previous studies in other pathologies showing a correlation between spinal CST integrity and motor function [7,8,37].…”

Section: Discussionsupporting

confidence: 89%

“…For example, sensory function has been found to correlate with DTI integrity of posterior tracts, and fine finger movements with CST integrity [6,37]. Furthermore, DTI measures also correlate with symptom severity and functional deficits in other disorders affecting the spinal cord such as amyotrophic lateral sclerosis [7], syringomyelia [38], multiple sclerosis [8] and spinal cord injury [25,37,39].…”

Section: Discussionmentioning

confidence: 99%

“…However, clinical symptoms in cervical spondylosis are not systematically associated with spinal anatomical MRI signs [5,6]. Diffusion tensor imaging (DTI) is a promising imaging method for quantifying spinal cord structure and some recent studies suggest that DTI could provide useful biomarkers in various spinal pathologies [7][8][9]. In cervical spondylosis with neurological symptoms, spinal DTI is more sensitive than conventional imaging [6,[10][11][12][13] and spinal cord damage detected with DTI can relate to severity of symptoms [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

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Correlation of force control with regional spinal DTI in patients with cervical spondylosis without signs of spinal cord injury on conventional MRI

et al. 2015

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Correlation of force control with regional spinal DTI in patients with cervical spondylosis without signs of spinal cord injury on conventional MRI

et al. 2015

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“…. With the development of new methods such as cardiac and respiratory gating, DTI and magnetization transfer (MT) can detect changes in the spinal cord in ALS [142][143][144]. Detection of infraclinical abnormalities in the sensory tracts shows the sensitivity of this approach [145][146].…”

Section: Advanced Methods Of Spinal Cord Imagingmentioning

confidence: 99%

Further development of biomarkers in amyotrophic lateral sclerosis

Blasco

Vourc’h

et al. 2016

Expert Review of Molecular Diagnostics

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In this review, we specifically focus on biology and imaging markers. We detail the innovative field of 'omics' approach and imaging and explain their limits to be useful in routine practice. We describe the most relevant biomarkers and suggest some perspectives for biomarker research. Expert commentary: The successive failures of clinical trials in ALS underline the need for new strategy based on innovative tools to stratify patients and to evaluate their responses to treatment. Biomarker data may be useful to improve the designs of clinical trials. Biomarkers are also needed to better investigate disease pathophysiology, to identify new therapeutic targets, and to improve the performance of clinical assessments for diagnosis and prognosis in the clinical setting. A consensus on the best management of neuroimaging and 'omics' methods is necessary and a systematic independent validation of findings may add robustness to future studies.

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“…Due to the limited field of view (FOV), DTI can only capture partial human spinal cord, such as the cervical, thoracic, and lumbar portion (Nair et al, 2010;Filippi et al, 2010) to enable high resolution imaging in modern clinical studies. The studies of normal aging and many diseases often require DTI of the entire spinal cord.…”

Section: Introductionmentioning

confidence: 99%