Diffusion-weighed MR imaging of pancreatic carcinoma

Matsuki, Mitsuru; Inada, Yuji; Nakai, Go; Tatsugami, Fuminari; Tanikake, Masato; Narabayashi, Isamu; Masuda, Daisuke; Arisaka, Yoshifumi; Takaori, Kyoichi; Tanigawa, Nobuhiko

doi:10.1007/s00261-007-9192-6

Cited by 144 publications

(97 citation statements)

References 2 publications

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“…Diffusion-weighted MRI and apparent diffusion coefficient (ADC) measurements have been applied to the abdomen (2)(3)(4)(5). The results suggest that ADC measurements can be useful in the evaluation of diffuse liver (6) and renal diseases (7,8) as well as for characterizing focal hepatic (4, 9), pancreatic (10)(11)(12)(13)(14)(15), and renal (16) lesions. The purpose of our study was to evaluate DWI findings and measure the difference between ADC values of normal pancreas parenchyma, mass-forming focal pancreatitis (FP) and pancreas carcinoma (PC).…”

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confidence: 99%

Apparent diffusion coefficient measurements of the pancreas, pancreas carcinoma, and mass-forming focal pancreatitis

et al. 2012

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Background: Mass-forming focal pancreatitis (FP) may mimic pancreatic cancer (PC) on magnetic resonance (MR) imaging, and the preoperative differential diagnosis is often difficult. Recently, the usefulness of diffusion-weighted imaging (DWI) in the diagnosis of pancreatic cancer has been reported in several studies. Purpose: To investigate if apparent diffusion coefficient (ADC) measurements based on diffusion-weighted echo-planar imaging (DW-EPI) may distinguish between normal pancreas parenchyma, mass-forming focal pancreatitis, and pancreas carcinoma. Material and Methods: MRI was performed on 64 patients: 24 with pancreas carcinoma (PC), 20 with massforming focal pancreatitis (FP), three patients with other focal pancreatic disease as well as 17 controls without any known pancreatic disease. Diffusion-weighted sequence with ADC maps and T2-weighted sequence for anatomical information was performed. Apparent diffusion coefficient (ADC) maps were automatically created and analyzed using a dedicated user interface. In the group with pancreas disease the abnormal parenchyma was detected by using T1-and T2-weighted images and the region of interest (ROI) was transferred exactly to the ADC map and the coefficients were registered. In the control group the ROI was set to the head of the pancreas followed by a similar registration of the ADCs. Results: ADC values for mass-forming FP and PC differed significantly from ADC values for normal pancreas parenchyma (P ¼ 0.001/P ¼ 0.002). Mean ADC values for mass-forming FP were 0.69 + 0.18 Â 10 23 mm 2 /s.

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Apparent diffusion coefficient measurements of the pancreas, pancreas carcinoma, and mass-forming focal pancreatitis

et al. 2012

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“…Noninvasive diffusion-weighted magnetic resonance (MR) imaging is a wellstudied MR imaging technique for quantifying the increase in water diffusion caused by cell necrosis or apoptosis in tumors within 2-4 days, prior to visible changes in tumor morphology or size, in responding patients with breast (20-23), brain (24,25), and pancreatic (26,27) cancers. It is an imaging method that could be utilized to evaluate early antitumor efficacy of TRA-8 in patients with breast cancer.…”

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Breast Tumor Xenografts: Diffusion-weighted MR Imaging to Assess Early Therapy with Novel Apoptosis-Inducing Anti-DR5 Antibody

Kim

Morgan²,

Zeng³

et al. 2008

Radiology

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Purpose:To measure the early therapeutic response to a novel apoptosis-inducing antibody, TRA-8, by using diffusionweighted magnetic resonance (MR) imaging in a mouse breast cancer model. Materials and Methods:Animal experiments had institutional animal care and use committee approval. Four groups of nude mice bearing luciferase-positive breast tumors (four to five mice with eight to 10 tumors per group) were injected intravenously with 0 mg (group 1), 0.025 mg (group 2), 0.100 mg (group 3), or 0.200 mg (group 4) of TRA-8 on days 0 and 3. Diffusion-weighted imaging, anatomic MR imaging, and bioluminescence imaging were performed on days 0, 3, and 6 before dosing. Averaged apparent diffusion coefficients (ADCs) for both whole tumor volume and a 1-mm peripheral tumor shell were calculated and were compared with tumor volume and living tumor cell changes. After imaging at day 6, proliferating and apoptotic cell densities were measured with Ki67 and terminal deoxynucleotidyl transferase mediated dUTP nick end labeling, or TUNEL, staining, respectively, and were compared with cleaved caspase-3 density. Results:The ADC increase at day 3 was dependent on TRA-8 dose level, averaging 6% Ϯ 3 (standard error of mean), 19% Ϯ 4, 14% Ϯ 4, and 34% Ϯ 7 in the whole tumor volume and 1% Ϯ 2, 9% Ϯ 5, 13% Ϯ 5, and 30% Ϯ 8 in the outer 1-mm tumor shell only for groups 1, 2, 3, and 4, respectively. The ADC increase in group 4 was significantly higher (P ϭ .0008 and P ϭ .0189 for whole tumor volume and peripheral region, respectively) than that in group 1 on day 3, whereas tumor size did not significantly differ. At day 3, the dose-dependent ADC increases were linearly proportional to apoptotic cell and cleaved caspase-3 densities and were inversely proportional to the density of cells showing Ki67 expression. Conclusion:Diffusion-weighted imaging enabled measurement of early breast tumor response to TRA-8 treatment, prior to detectable tumor shrinkage, providing an effective mechanism to noninvasively monitor TRA-8 efficacy.

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“…An improvement in MRI technique is the use of diffusion weighted MRI (DWI-MRI) for abdominal imaging. DWI is an MRI technique that detects changes in the molecular diffusion of water in biologic tissues and the valuable role of DWI in the detection of pancreatic tumors has been reported in several studies (Figure 4a,4b & 5) [33][34][35][36].…”

Section: Mrimentioning

confidence: 99%

Insulinoma: Literature’s Review (2)

AlJadir¹

2015

EMIJ

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Diffusion-weighed MR imaging of pancreatic carcinoma

Abstract: Diffusion-weighted (DW) images can be helpful in detecting the pancreatic carcinoma and accessing the extent of the tumor.

Cited by 144 publications

References 2 publications

Apparent diffusion coefficient measurements of the pancreas, pancreas carcinoma, and mass-forming focal pancreatitis

Apparent diffusion coefficient measurements of the pancreas, pancreas carcinoma, and mass-forming focal pancreatitis

Breast Tumor Xenografts: Diffusion-weighted MR Imaging to Assess Early Therapy with Novel Apoptosis-Inducing Anti-DR5 Antibody

Insulinoma: Literature’s Review (2)

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