Diffusion-weighted EPI of cystic ovarian lesions: Evaluation of cystic contents using apparent diffusion coefficients

Moteki, Takao; Ishizaka, Hiroshi

doi:10.1002/1522-2586(200012)12:6<1014::aid-jmri29>3.0.co;2-t

Cited by 86 publications

(40 citation statements)

References 21 publications

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“…There are some reports about the clinical application of DWI to diagnose cystic ovarian tumors ( [21,22]. Furthermore, mature cystic teratoma is lined with keratinized squamous epithelium in most cases [23].…”

Section: Differentiation Of Ovarian Tumorsmentioning

confidence: 99%

“…Among malignant ovarian tumors, the ADC varied widely (Figs. 6, 9), a phenomenon attributable to their morphologic variety [21][22][23]. The ADC is useful for distinguishing mature cystic teratomas and endometrial cysts from other cystic tumors.…”

Section: Differentiation Of Ovarian Tumorsmentioning

confidence: 99%

“…The ADC value within the mass is 0.87×10 -3 mm 2 /s identify the ADC threshold for differentiating among cystic ovarian tumors. The role of DWI in distinguishing between benign and malignant cystic tumors may thus be limited [21][22][23]. The ADC values calculated from the DWI may add useful information to the differential diagnosis of ovarian cystic masses in limited populations, such as those with mature cystic teratomas with a small amount of fat [23].…”

Section: Differentiation Of Ovarian Tumorsmentioning

confidence: 99%

“…It also permits the quantitative evaluation of the apparent diffusion coefficient (ADC) that may be useful for distinguishing between malignant and benign tissues and for monitoring therapeutic outcomes [5][6][7][8][9][10][11]. As there are few studies on the utility of DWI for gynecological imaging [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26], we reviewed its applicability for examining the female pelvic region and discuss the future of MRI in patients with gynecological diseases.…”

Section: Introductionmentioning

confidence: 99%

“…The cystic components of endometrial cysts and malignant ovarian cystic tumors exhibited lower ADC values than other benign ovarian cysts without bleeding and benign cystic neoplasms (Figs 6,7,8) [21,22]…”

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confidence: 99%

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Role of diffusion-weighted imaging in the diagnosis of gynecological diseases

et al. 2008

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Recent technical advances in diffusion-weighted imaging (DWI) greatly enhanced the clinical value of magnetic resonance imaging (MRI) of the body. DWI can provide excellent tissue contrast based on molecular diffusion and may be able to demonstrate malignant tumors. Quantitative measurement of the apparent diffusion coefficient (ADC) may be valuable in distinguishing between malignant and benign lesions. We reviewed DWI and conventional MRI of the female pelvis to study the utility of DWI in patients with gynecological diseases. Although the ADC can help to differentiate between normal and cancerous tissue in the uterine cervix and endometrium, its utility may be limited by the large overlap of the uterine myometrium and ovaries. On the other hand, the ADC may be useful for monitoring the therapeutic outcome after uterine arterial embolizati (UAE), chemotherapy and/or radiation therapy. In patients with ovarian cancer, DWI demonstrates high intensity not only at the primary cancer site but also in disseminated peritoneal implants. When added to conventional MRI findings, DWI and ADC values provide additional information and DWI may play an important role in the diagnosis of patients with gynecological diseases.

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Section: Differentiation Of Ovarian Tumorsmentioning

confidence: 99%

Section: Differentiation Of Ovarian Tumorsmentioning

confidence: 99%

Section: Differentiation Of Ovarian Tumorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Role of diffusion-weighted imaging in the diagnosis of gynecological diseases

et al. 2008

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Evaluation of hepatic lesions and hepatic parenchyma using diffusion‐weighted reordered turboFLASH magnetic resonance images

Moteki

Horikoshi

et al. 2002

Magnetic Resonance Imaging

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In vivo measurement of the apparent diffusion coefficient in normal and malignant prostatic tissues using echo‐planar imaging

Issa

2002

Magnetic Resonance Imaging

225

197

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Purpose: To measure for the first time the apparent diffusion coefficient (ADC) values in anatomical regions of the prostate for normal and patient groups, and to investigate its use as a differentiating parameter between healthy and malignant tissue within the patient group. Materials and Methods:Single-shot diffusion-weighted echo-planar imaging (DW-EPI) was used to measure the ADC in the prostate in normal (N ϭ 7) and patient (N ϭ 19) groups. The spin-echo images comprised 96 ϫ 96 pixels (field of view of 16 cm, TR/TE ϭ 4000/120 msec) with six b-factor values ranging from 64 to 786 seconds/mm 2 . Results:The ADC values averaged over all patients in noncancerous and malignant peripheral zone (PZ) tissues were 1.82 Ϯ 0.53 ϫ 10 -3 (mean Ϯ SD) and 1.38 Ϯ 0.52 ϫ 10 -3 mm 2 /second, respectively (P ϭ 0.00045, N ϭ 17, paired t-test). The ADC values were found to be higher in the non-cancerous PZ (1.88 Ϯ 0.48 ϫ 10 -3 ) than in healthy or benign prostatic hyperplasia central gland (BPH-CG) region (1.62 Ϯ 0.41 ϫ 10 -3 ). For the normal group, the mean values were 1.91 Ϯ 0.46 ϫ 10 -3 and 1.63 Ϯ 0.30 ϫ 10 -3 mm 2 /second for the PZ and CG, respectively (P ϭ 0.011, N ϭ 7). Significant overlap exists between individual values among all tissue types. Furthermore, ADC values for the same tissue type showed no statistically significant difference between the two subject groups. Conclusion:ADC is quantified in the prostate using DW-EPI. Values are lower in cancerous than in healthy PZ in patients, and in BPH-CG than PZ in volunteers.

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Diffusion-weighted EPI of cystic ovarian lesions: Evaluation of cystic contents using apparent diffusion coefficients

Cited by 86 publications

References 21 publications

Role of diffusion-weighted imaging in the diagnosis of gynecological diseases

Role of diffusion-weighted imaging in the diagnosis of gynecological diseases

Evaluation of hepatic lesions and hepatic parenchyma using diffusion‐weighted reordered turboFLASH magnetic resonance images

In vivo measurement of the apparent diffusion coefficient in normal and malignant prostatic tissues using echo‐planar imaging

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