Diffusion-weighted imaging (DWI) of the spleen in patients with liver cirrhosis and portal hypertension

Klasen, Janina; Lanzman, Rotem S.; Wittsack, Hans‐Jörg; Kircheis, G.; Schek, Julia; Quentin, Michael; Antoch, Gerald; Häussinger, Dieter; Blondin, D.

doi:10.1016/j.mri.2013.01.003

Cited by 24 publications

(28 citation statements)

References 26 publications

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“…Patients with liver fi-brosis usually develop portal hypertension, causing splenomegaly, which can result in increased heterogeneity of the spleen parenchyma on ADC maps as well as changes in water diffusion. 12 DW-MRI is a non-invasive technique of great usefulness in the detection and differentiation of pathological lesions in the whole body, including the abdomen. However, there are some limitations to this method.…”

Section: Discussionmentioning

confidence: 99%

Which organ should be considered as a reference in diffusion weighted imaging of the abdomen? - repeatability of ADC measurements of the spleen and the renal cortex on a 1.5T MR

Pawluś¹,

Szymańska

Łasecki³

et al. 2017

Adv Clin Exp Med

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Section: Discussionmentioning

confidence: 99%

Which organ should be considered as a reference in diffusion weighted imaging of the abdomen? - repeatability of ADC measurements of the spleen and the renal cortex on a 1.5T MR

Pawluś¹,

Szymańska

Łasecki³

et al. 2017

Adv Clin Exp Med

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“…Several authors have proposed to use the spleen as a reference organ for ADC measurements of liver parenchyma [29,62] in order to decrease variability of liver ADC measurements despite the fact that patients with cirrhosis and portal hypertension frequently suffer from splenomegaly (enlargement of the spleen) [63] . Klasen et al [63] demonstrated that patients with liver cirrhosis and portal hypertension had significantly higher spleen ADCs.…”

Section: Spleenmentioning

confidence: 99%

“…Klasen et al [63] demonstrated that patients with liver cirrhosis and portal hypertension had significantly higher spleen ADCs. Spleen T2-relaxation times are 79 ± 15 ms and 61 ± 9 ms at 1.5T and 3.0T respectively [50] and some studies [24,64] did use echo times significantly higher than the T2-relaxation time.…”

Section: Spleenmentioning

confidence: 99%

Diffusion-weighted magnetic resonance imaging in cancer: Reported apparent diffusion coefficients,in-vitroandin-vivoreproducibility

Jafar

Parsaï

Miquel

2016

WJR

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There is considerable disparity in the published apparent diffusion coefficient (ADC) values across different anatomies. Institutions are increasingly assessing repeatability and reproducibility of the derived ADC to determine its variation, which could potentially be used as an indicator in determining tumour aggressiveness or assessing tumour response. In this manuscript, a review of selected articles published to date in healthy extracranial body diffusion-weighted magnetic resonance imaging is presented, detailing reported ADC values and discussing their variation across different studies. In total 115 studies were selected including 28 for liver parenchyma, 15 for kidney (renal parenchyma), 14 for spleen, 13 for pancreatic body, 6 for gallbladder, 13 for prostate, 13 for uterus (endometrium, myometrium, cervix) In addition, six phantom studies and thirteen in vivo studies were summarized to compare repeatability and reproducibility of the measured ADC. All selected phantom studies demonstrated lower intra-scanner and inter-scanner variation compared to in vivo studies. Based on the findings of this manuscript, it is recommended that protocols need to be optimised for the body part studied and that system-induced variability must be established using a standardized phantom in any clinical study. Reproducibility of the measured ADC must also be assessed in a volunteer population, as variations are far more significant in vivo compared with phantom studies. Core tip: Diffusion-weighted magnetic resonance imaging was highlighted as a potential cancer imaging biomarker by a team of experts in a report published in 2009. We review the variability of published diffusion values in the major extra-cranial organs and focus on the validation literature, both in vivo and in vitro . A total of 115 studies were selected including for liver parenchyma, kidney, pancreatic body, spleen, gallbladder, prostate, uterus (endometrium, myometrium, cervix) and breast. We also look in detail at the published repeatability and reproducibility studies, both in vivo and in phantoms. A series of recommendations based on our findings are given at the end of this review.Jafar MM, Parsai A, Miquel ME. Diffusion-weighted magnetic resonance imaging in cancer: Reported apparent diffusion coefficients, in vitro and in vivo reproducibility.

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“…The technique may be useful in determining pathology in the liver (degree of cirrhosis/fibrosis), kidneys (lesion characterization, renal failure, pyelonephritis), pancreas (pancreatitis and pancreatic cancer), bowel (Crohn's disease), and uterus (endometriosis) [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] . In a recent meta-analysis, Li et al [19] has shown a potential future role for this type of sequence to assess for cancers within the liver.…”

Section: Introductionmentioning

confidence: 99%

Impact of field strength and RF excitation on abdominal diffusion-weighted magnetic resonance imaging

Riffel¹,

Rao²,

Haneder³

et al. 2013

WJR

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AIM:To retrospectively and prospectively compare diffusion-weighted (DW) images in the abdomen in a 1.5T system and 3.0T systems with and without twochannel functionality for B1 shimming.METHODS: DW images of the abdomen were obtained on 1.5T and 3.0T (with and without two-channel functionality for B1 shimming) scanners on 150 patients (retrospective study population) and 10 volunteers (prospective study population). Eight regions were selected for clinical significance or artifact susceptibility (at higher field strengths). Objective grading quantified signal-to-noise ratio (SNR), and subjective evaluation qualified image quality, ghosting artifacts, and diagnostic value. Statistical significance was calculated using χ 2 tests (categorical variables) and independent two-sided t tests or Mann-Whitney U tests (continuous variables). RESULTS:The 3.0T using dual-source parallel transmit (dpTX 3.0T) provided the significantly highest SNRs in nearly all regions. In regions susceptible to artifacts at higher field strengths (left lobe of liver, head of pancreas), the SNR was better or similar to the 1.5T system. Subjectively, both dpTX 3.0T and 1.5T systems provided higher image quality, diagnostic value, and less ghosting artifact (P < 0.01, most values) compared to the 3.0T system without dual-source parallel transmit (non-dpTX 3.0T). CONCLUSION:The dpTX 3.0T scanner provided the highest SNR. Its image quality, lack of ghosting, and diagnostic value were equal to or outperformed most currently used systems. © 2013 Baishideng. All rights reserved.Key words: Abdominal imaging; Diffusion weighted; 3.0T; Radiofrequency excitation; Signal-to-noise ratio Core tip: With the popularity of 3.0T imaging systems, radiologists have commonly found limitations in abdominal imaging with diffusion-weighted imaging (DWI) secondary to B1 in homogeneity artifacts at these higher magnet strengths. Because artifacts disturb diagnostic value of abdominal DWI, 1.5T systems have been mainly used for this particular purpose. However, newer techniques involving 3.0T using dual-source parallel radiofrequency (RF) excitation with parallel transmission and independent RF shimming have recently been developed which may succeed in addressing such limitations. Our study illustrates both the objective and subjective utility in the abdominal distribution while imaging under a 3.0T system which incorporates dualsource RF excitation.

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Diffusion-weighted imaging (DWI) of the spleen in patients with liver cirrhosis and portal hypertension

Cited by 24 publications

References 26 publications

Which organ should be considered as a reference in diffusion weighted imaging of the abdomen? - repeatability of ADC measurements of the spleen and the renal cortex on a 1.5T MR

Which organ should be considered as a reference in diffusion weighted imaging of the abdomen? - repeatability of ADC measurements of the spleen and the renal cortex on a 1.5T MR

Diffusion-weighted magnetic resonance imaging in cancer: Reported apparent diffusion coefficients,in-vitroandin-vivoreproducibility

Impact of field strength and RF excitation on abdominal diffusion-weighted magnetic resonance imaging

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