Diffusion-weighted imaging in prostate cancer

Tamada, Tsutomu; Ueda, Yuichi; Ueno, Yoshiko; Kojima, Yuichi; Kido, Ayumu; Yamamoto, Akira

doi:10.1007/s10334-021-00957-6

Cited by 21 publications

(12 citation statements)

References 111 publications

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“…Previous studies have reported excellent discrimination between the benign region and PC according to ADC (AUC of 0.9 or higher), which supports our results of tumor detection ability using mean ADC 10,26 . For assessment of tumor aggressiveness in PC, the present study found no significant correlation between tumor ADC and GG, and ROC analysis also showed low discriminatory ability for tumor ADC.…”

Section: Discussionsupporting

confidence: 89%

Comparison Between Amide Proton Transfer Magnetic Resonance Imaging Using 3-Dimensional Acquisition and Diffusion-Weighted Imaging for Characterization of Prostate Cancer: A Preliminary Study

Kido

Tamada

Ueda³

et al. 2022

J Comput Assist Tomogr

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Objective: This study aimed to compare diagnostic performance for tumor detection and for assessment of tumor aggressiveness in prostate cancer (PC) between amide proton transfer magnetic resonance imaging (MRI) with 3-dimensional acquisition (3DAPT) and diffusion-weighted imaging. Methods:The subjects were 23 patients with 27 pathologically proven PCs who underwent 3T multiparametric MRI. With reference to the pathology findings, 2 readers in consensus identified the location of PC on multiparametric MRI and measured APT signal intensity (APT SI [%]) and mean apparent diffusion coefficient (ADC) of the benign region and each PC lesion. Results:The mean ADC showed a significant difference between benign regions and PC lesions (0.74 ± 0.15 vs 1.37 ± 0.21, P < 0.001), whereas APT SI did not (P = 0.091). Lesion APT SI was significantly higher and lesion ADC was significantly lower in PCs with Gleason group (GG) ≥3 than in PCs with GG ≤2 (3.37 ± 1.30 vs 1.78 ± 0.67, P < 0.001, and 0.71 ± 0.18 vs 0.79 ± 0.10, P = 0.038, respectively). The APT SI was significantly higher in GG3 than in GG1, in GG3 than in GG2, and in GG4 than in GG2 (P = 0.009, P = 0.001, and P = 0.006, respectively). The area under the curve for separating tumor lesions and benign regions was 0.601 for 3DAPT and 0.983 for ADC (P < 0.001). The area under the curve for separating tumors with GG ≤2 from tumors with GG ≥3 was 0.912 for 3DAPT and 0.734 for ADC (P = 0.172). Conclusions:In patients with PC, it might be preferable to use ADC to discriminate benign from malignant tissue and use APT SI for assessment of tumor aggressiveness.

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Section: Discussionsupporting

confidence: 89%

Comparison Between Amide Proton Transfer Magnetic Resonance Imaging Using 3-Dimensional Acquisition and Diffusion-Weighted Imaging for Characterization of Prostate Cancer: A Preliminary Study

Kido

Tamada

Ueda³

et al. 2022

J Comput Assist Tomogr

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“… 34 More recently, comparison of bpMRI with mpMRI in combination with PSA density (PSAD) in the detection of clinically significant prostate cancer showed bpMRI combined with PSAD to achieve a better detection rate than mpMRI in Asian patients. 35 Diffusion-weighted imaging as part of mpMRI techniques has recently been investigated in a Japanese study for the detection of clinically significant prostate cancer in patients with elevated PSA levels, 36 and further refinement to the use of these techniques in Asia is likely to be forthcoming.…”

Section: Resultsmentioning

confidence: 99%

Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with prostate cancer

Kanesvaran

Castro²,

Wong

et al. 2022

ESMO Open

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“…This sensitivity to diffusion results from the applied b-values whose quality depends on the gradient properties during the pulse sequence design. The role of DWI in differentiating malignant neoplastic tissue from healthy tissue or predicting treatment response has been investigated in most, if not all, tumor types [52][53][54][55][56][57] . Although its resolution (2-5 mm 2 in plane) is typically lower than those of structural sequences, its b-value dependent contrast with cell-rich tumor tissue and its ability to provide tissue-specific ADCs have demonstrated great success in identifying tumor tissue.…”

Section: Dwi Diffusion-tensor Imaging and Intravoxel-incoherent Motio...mentioning

confidence: 99%

Imaging in translational cancer research

Kurz

2022

Cancer Biol Med

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This review is aimed at presenting some of the recent developments in translational cancer imaging research, with a focus on novel, recently established, or soon to be established cross-sectional imaging techniques for computed tomography (CT), magnetic resonance imaging (MRI), and positron-emission tomography (PET) imaging, including computational investigations based on machine-learning techniques.

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Diffusion-weighted imaging in prostate cancer

Cited by 21 publications

References 111 publications

Comparison Between Amide Proton Transfer Magnetic Resonance Imaging Using 3-Dimensional Acquisition and Diffusion-Weighted Imaging for Characterization of Prostate Cancer: A Preliminary Study

Comparison Between Amide Proton Transfer Magnetic Resonance Imaging Using 3-Dimensional Acquisition and Diffusion-Weighted Imaging for Characterization of Prostate Cancer: A Preliminary Study

Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with prostate cancer

Imaging in translational cancer research

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