Diffusion-Weighted Imaging of Prostate Cancer

Abstract

The addition of DW imaging to conventional T2W imaging provides better detection of prostate cancer.

Diffusion weighted imaging in prostate cancer

“…Miao et al [16] showed that the sensitivity and specificity rates for T2WI was 76% and 70% respectively, compared with 86% and 80% for DWI. Combined T2WI and DWI yield slightly better results, with reported sensitivity and specificity rates of 45-89% and 61-97% respectively, compared with 74-85% and 57-95% respectively for DWI alone and 25-87% and 57-92% respectively for T2WI alone [12,15,[17][18][19][20][21][22][23][24][25][26].…”

“…This may be attributed to increased contrast on DWI images compared with conventional imaging [46]. When combined with T2-weighted imaging, the sensitivity and specificity for PC range from 71 to 89% and 61 to 91% respectively, compared with 51-86% and 60-84% respectively for T2WI alone [17,19,21,22,47]. Lim et al [24] showed that combined T2WI and DWI imaging increased the AUC among readers from 0.66-0.79 for T2WI alone and 0.74-0.86 for DWI alone, to 0.76-0.9 (p<0.001).…”

“…ADC values for malignant tissue are commonly lower than those of normal PZ and TZ [27,29], as well as BPH nodules [30]. Shimofusa et al [21] found that DWI detected tumour in the TZ in 5 out of 8 (63%) patients, compared with one out of 8 (13%) patients detected using T2WI. Yoshimitsu et al found that the mean tumour volume in the TZ detected by DWI increased from 20% to 52% compared with T2WI (p<0.0001) [17].…”

A non-invasive image based system for early diagnosis of prostate cancer.

“…However, the reported results demonstrated low diagnostic sensitivity [115]. To increase the sensitivity of diagnosis, Shimofusa et al [34] suggested the addition of strong magnetic field gradient pulses (b-values) to the pulse sequence instead of using an endorectal coil. In their study [34], they detected the tumor in the central zone of the prostate in five of eight total patients using DWI with strong magnetic field gradient pulses.…”

“…To increase the sensitivity of diagnosis, Shimofusa et al [34] suggested the addition of strong magnetic field gradient pulses (b-values) to the pulse sequence instead of using an endorectal coil. In their study [34], they detected the tumor in the central zone of the prostate in five of eight total patients using DWI with strong magnetic field gradient pulses. Alternatively, the compared diagnostic results with T 2 -weighted imaging, detected the tumor only in one of the eight patients.…”