Diffusion-weighted imaging of the abdomen using echo planar imaging with compressed SENSE: Feasibility, image quality, and ADC value evaluation

Kaga, Tetsuro; Noda, Yoshifumi; Mori, Takayuki; Kawai, Nobuyuki; Takano, Hirotaka; Kajita, Kimihiro; Yoneyama, Masami; Akamine, Yuta; Kato, Hiroki; Hyodo, Fuminori

doi:10.1016/j.ejrad.2021.109889

Cited by 19 publications

(12 citation statements)

References 16 publications

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“…With the development of magnetic resonance imaging (MRI) equipment hardware and software, diffusion weighted imaging (DWI) is increasingly used in the evaluation of diseases in abdominal organs [ 9 – 11 ]. Conventional DWI calculates the apparent diffusion coefficient (ADC) to quantify the random motion of water molecules in biological tissues, but this monoexponential model assumes that water molecules follow a Gaussian statistical distribution [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Noninvasive assessment of clinical and pathological characteristics of patients with IgA nephropathy by diffusion kurtosis imaging

Liang

Yuan

et al. 2022

Insights Imaging

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Objectives To explore the diagnostic performance of diffusion kurtosis imaging (DKI) in evaluating the clinical and pathological characteristics of patients with immunoglobulin A nephropathy (IgAN) compared with conventional DWI. Materials and methods A total of 28 IgAN patients and 14 healthy volunteers prospectively underwent MRI examinations including coronal T2WI, axial T1WI, T2WI, and DWI sequences from September 2020 to August 2021. We measured mean kurtosis (MK), mean diffusivity (MD), and apparent diffusion coefficient (ADC) by using MR Body Diffusion Toolbox v1.4.0 (Siemens Healthcare). Patients were divided into three groups according to their estimated glomerular filtration rate (eGFR) (Group1, healthy volunteers without kidney disease or other diseases that affect renal function; Group2, IgAN patients with eGFR > 60 mL/min/1.73 m2; Group3, IgAN patients with eGFR < 60 mL/min/1.73 m2). One-way analysis of variance, Pearson or Spearman correlation, and receiver operating characteristic curves were applied in our statistical analysis. Results MKCortex and ADCCortex showed significant differences between the Group1 and Group2. MKCortex, MDCortex, ADCCortex, MKMedulla, and ADCMedulla showed significant differences between Group2 and Group3. MKCortex had the highest correlation with CKD stages (r = 0.749, p < 0.001), and tubulointerstitial lesion score (r = 0.656, p < 0.001). MDCortex had the highest correlation with glomerular lesion score (r = − 0.475, p = 0.011). MKCortex had the highest AUC (AUC = 0.923) for differentiating Group1 from Group2, and MDCortex had the highest AUC (AUC = 0.924) for differentiating Group2 from Group3, followed by MKMedulla (AUC = 0.923). Conclusions DKI is a feasible and reliable technique that can assess the clinical and pathological characteristics of IgAN patients and can provide more valuable information than conventional DWI, especially MKCortex.

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Section: Introductionmentioning

confidence: 99%

Noninvasive assessment of clinical and pathological characteristics of patients with IgA nephropathy by diffusion kurtosis imaging

Liang

Yuan

et al. 2022

Insights Imaging

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“…Respiratory‐triggering can reduce artifacts in DWI protocols at the cost of a long and uncertain scan time, which markedly reduces patient comfort 33–35 but improve the image quality of the pancreas 36 . In our study, four different DWI sequences were carried out with respiratory‐triggering and the mean ADC values of 1356.50–2169.53 × 10 −6 mm 2 /sec for the head, body, and tail sections fell in the range of previous reports 20,37 . Moreover, FOCUS‐MUSE DWI had the highest intraobserver and interobserver agreements of ADC measurements, which may be attributed to fewer susceptibility artifacts with the FOCUS technique 14 and shorter T2 signal decay with MUSE method 7 .…”

Section: Discussionmentioning

confidence: 62%

“…36 In our study, four different DWI sequences were carried out with respiratory-triggering and the mean ADC values of 1356.50-2169.53 Â 10 À6 mm 2 /sec for the head, body, and tail sections fell in the range of previous reports. 20,37 Moreover, FOCUS-MUSE DWI had the highest intraobserver and interobserver agreements of ADC measurements, which may be attributed to fewer susceptibility artifacts with the FOCUS technique 14 and shorter T2 signal decay with MUSE method. 7 Therefore, FOCUS-MUSE DWI may be sufficiently reliable and repeatable when diagnosing pancreatic diseases.…”

Section: Discussionmentioning

confidence: 93%

MRI: Evaluating the Application of FOCUS‐MUSE Diffusion‐Weighted Imaging in the Pancreas in Comparison With FOCUS, MUSE, and Single‐Shot DWIs

Pei

Liu²,

Liu

et al. 2022

Magnetic Resonance Imaging

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Background Diffusion‐weighted imaging (DWI) is a useful technique to detect pancreatic lesion. In DWIs, field‐of‐view optimized and constrained undistorted single‐shot (FOCUS) can improve the spatial resolution and multiplexed sensitivity‐encoding (MUSE) can gain a high signal‐to‐noise ratio (SNR). Based on the advantage of FOCUS and MUSE, a new DWI sequence—named FOCUS‐MUSE DWI (FOCUS combined with MUSE)—was developed to delineate the pancreas. Purpose To investigate the reliability of FOCUS‐MUSE DWI compared to FOCUS, MUSE and single‐shot (SS) DWI via the systematical evaluation of the apparent diffusion coefficient (ADC) measurements, SNR and image quality. Study Type Prospective. Subjects A total of 33 healthy volunteers and 9 patients with pancreatic lesion. Field Strength/Sequence A 3.0 T scanner. FOCUS‐MUSE DWI, FOCUS DWI, MUSE DWI, SS DWI. Assessment For volunteers, ADC and SNR were measured by two readers in the pancreatic head, body, and tail. For all subjects, the diagnostic image quality score was assessed by three other readers on above four DWIs. Statistical Tests Paired‐sample T‐test, intraclass correlation (ICC), Bland–Altman method, Friedman test, Dunn‐Bonferroni post hoc test and kappa coefficient. A significance level of 0.05 was used. Results FOCUS‐MUSE DWI had the best intersession repeatability of ADC measurements (head: 59.53, body: 101.64, tail: 42.30) among the four DWIs, and also maintained the significantly highest SNR (reader 1 [head: 19.68 ± 3.23, body: 23.42 ± 5.00, tail: 28.85 ± 4.96], reader 2 [head: 19.93 ± 3.52, body: 23.02 ± 5.69, tail: 29.77 ± 6.33]) except for MUSE DWI. Furthermore, it significantly achieved better image quality in volunteers (median value: 4 score) and 9 patients (most in 4 score). Data Conclusion FOCUS‐MUSE DWI improved the reliability of pancreatic images with the most stable ADC measurement, best image quality score and sufficient SNR among four DWIs. Evidence Level 2 Technical Efficacy Stage 2

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“…In addition, CV of ADC value was used to assess the relative degree of dispersion between ADC value measurements, which was calculated as the following formula: Here, SD was the standard deviation of ADC value and ADC Mean was the mean value of ADC value in various representive point 39 . It indicated that the ADC measurement was reliable when CV less than 0.15.…”

Section: Methodsmentioning

confidence: 99%

Comparing the clinical utility of single-shot, readout-segmented and zoomit echo-planar imaging in diffusion-weighted imaging of the kidney at 3 T

Liu

Xie

et al. 2022

Sci Rep

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We compared the clinical utility of single-shot echo-planar imaging (SS-EPI) using different breathing schemes, readout-segmented EPI and zoomit EPI in the repeatability of apparent diffusion coefficient (ADC) measurements, cortico-medullary contrast to noise ratio (c-mCNR) and image quality. In this institutional review board-approved prospective study, some common clinically applicable diffusion-weighted imaging (b = 50, 400, 800 s/mm2) of kidney on 3.0 T MRI were performed on 22 volunteers using SS-EPI with breath-hold diffusion-weighted imaging (BH-DWI), free-breathing (FB-DWI), navigator-triggered (NT-DWI) and respiratory-triggered (RT-DWI), readout-segmented DWI (RS-DWI), and Zoomit DWI (Z-DWI). ADC and c-mCNR were measured in 12 anatomic locations (the upper, middle, and lower pole of the renal cortex and medulla), and image quality was assessed on these DWI sequences. A DWI with the optimal clinical utility was decided by systematically assessing the ADC repeatability, c-mCNR and image quality among the DWIs. For ADC measurements, Z-DWI had an excellent intra-observer agreement (intra-class correlation coefficients (ICCs): 0.876–0.944) and good inter-observer agreement (inter-class ICCs: 0.798–0.856) in six DWI sequences. Z-DWI had the highest ADC repeatability in most of the 12 anatomic locations of the kidneys (mean ADC absolute difference: 0.070–0.111 × 10−3 mm2/s, limit of agreement: 0.031–0.056 × 10−3 mm2/s). In all DWIs, Z-DWI yielded a slightly higher c-mCNR than other DWIs in most representative locations (P > 0.05), which was significantly higher than BH-DWI and FB-DWI in the middle pole of both kidneys and the upper pole of the left kidney (P < 0.05). In addition, Z-DWI yielded image quality that was similar to RT-DWI and NT-DWI (P > 0.05) and superior to BH-DWI, FB-DWI and RS-DWI (P < 0.05). Our results suggest that Z-DWI provides the highest ADC reproducibility, better c-mCNR and good image quality on 3.0 T MRI, making it the recommended sequence for clinical DWI of the kidney.

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Diffusion-weighted imaging of the abdomen using echo planar imaging with compressed SENSE: Feasibility, image quality, and ADC value evaluation

Cited by 19 publications

References 16 publications

Noninvasive assessment of clinical and pathological characteristics of patients with IgA nephropathy by diffusion kurtosis imaging

Noninvasive assessment of clinical and pathological characteristics of patients with IgA nephropathy by diffusion kurtosis imaging

MRI: Evaluating the Application of FOCUS‐MUSE Diffusion‐Weighted Imaging in the Pancreas in Comparison With FOCUS, MUSE, and Single‐Shot DWIs

Comparing the clinical utility of single-shot, readout-segmented and zoomit echo-planar imaging in diffusion-weighted imaging of the kidney at 3 T

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