Diffusion-weighted magnetic resonance imaging can be used in place of positron emission tomography for N staging of non–small cell lung cancer with fewer false-positive results

Nomori, Hiroaki; Mori, Takeshi; Ikeda, Koei; Kawanaka, Koichi; Shiraishi, Shinya; Katahira, Kentaro; Yamashita, Yasuyuki

doi:10.1016/j.jtcvs.2007.10.035

Cited by 143 publications

(103 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Diffusion of water molecules in malignant tumors is usually restricted compared to that in normal tissue, resulting in a decreased apparent diffusion coefficient (ADC) value (Szafer et al, 1995;Takahara et al, 2004). Some recent studies comparing DWI with FDG-PET have shown that DWI at 1.5 T is comparable with FDG-PET for detecting malignant lesions (Komori et al, 2007;Nomori et al, 2008;Mori et al, 2008), and an meta-analysis has shown that DWI can be used to differentiate malignant from benign pulmonary lesions . It is uncertain whether DWI has advantages over FDG-PET for distinguishing malignant from benign pulmonary nodules and masses.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Performance of Diffusion Weighted Imaging of Malignant and Benign Pulmonary Nodules and Masses: Comparison with Positron Emission Tomography

Usuda

Sagawa

Motono

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Diagnostic Performance of Diffusion Weighted Imaging of Malignant and Benign Pulmonary Nodules and Masses: Comparison with Positron Emission Tomography

Usuda

Sagawa

Motono

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

“…Experience with thoracic applications of DWI techniques is still growing, and preliminary studies have reported promising results (24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35).…”

Section: Thoracic Applicationsmentioning

confidence: 99%

“…In heterogeneous tumors, care should be taken to place the ROI in the solid portion of the mass, excluding cystic or necrotic areas. DWI has been used to characterize lung lesions (27), to detect and classify adenocarcinomas (37), to predict tumor invasiveness in early-stage lung cancer (24), to detect tumors in collapsed lungs (32,33), and for nodal staging of lung cancer (26,35).…”

Section: Thoracic Applicationsmentioning

confidence: 99%

“…In an evaluation of 734 lymph nodes in 88 patients with non-small-cell lung carcinoma, Nomori et al (35) reported a sensitivity of 70% and a specificity of 97% using an ADC cutoff value of 1.6×10 -3 mm 2 /s. Similarly, Kosucu et al (26) reported that the ADC of metastatic lymph nodes was significantly lower than that of benign nodes.…”

Section: Thoracic Applicationsmentioning

confidence: 99%

See 1 more Smart Citation

Diffusion weighted MRI for detecting and monitoring cancer: a review of current applications in body imaging

Türkbey

Aras

Karabulut

et al. 2011

Diagn Interv Radiol

View full text Add to dashboard Cite

Imaging is used to detect, characterize, and monitor cancer. Recently, diffusion-weighted magnetic resonance imaging (DWI) has become a useful adjunct for assessing tumors with magnetic resonance imaging (MRI). DWI involves the acquisition of a magnetic resonance signal related to random thermal motion (Brownian motion) or the "diffusion" of water protons in tissue. The signal obtained with DWI is a measure of the net displacement of water molecules, e.g., the water path length in the extracellular, intracellular and intravascular spaces. This motion is largely random and can be reduced by structural barriers, such as cell membranes and collagen. Restricted diffusion in biological tissues is inversely proportional to tissue cellularity and the integrity of cell membranes, and it can be quantified with apparent diffusion coefficient (ADC) measurements (1). Depending on the microarchitecture, either restricted or increased diffusion can occur in malignant tumors. For instance, diffusion is restricted in cellular portions of the tumor, but it may be increased in necrotic portions (2, 3). Other causes of enhanced diffusion include increased water content arising from intratumoral edema and cystic tumor components (4-6).Although initially used to evaluate neurological diseases, the applications of DWI have been extended to oncologic imaging throughout the body made possible by improvements in MRI hardware and new sequences. The use of DWI as a complement to conventional MRI methods has led to improvements in the detection and characterization of tumors, treatment response monitoring, and detection of recurrence in oncology patients. Basic concepts of DWIIn 1965, Stejskal and Tanner (7) proposed the application of a symmetric pair of additional gradients on either side of the 180˚ refocusing radiofrequency pulse. The Stejskal-Tanner sequence is still the basis of modern DWI. For static water molecules, the phasing effect caused by the first gradient will be reversed by the second gradient, leading to no signal loss; however, this phasing effect will not be completely reversed if the water molecules are not stationary, which results in the observed well-known diffusion signal decay. The amount of diffusion weighting is determined by the b value, which describes the amplitude, duration of the applied gradient, and time interval between the two diffusion gradients (4). The degree of signal attenuation from water molecules is cor- ABSTRACT Diffusion-weighted magnetic resonance imaging (MRI), which involves the acquisition of a magnetic resonance signal related to the Brownian motion of water protons in tissue, has become a useful technique for assessing tumors. In this article, we review the basic concepts, imaging strategies, and body applications of diffusion-weighted MRI in detecting and monitoring cancer.

show abstract

“…Tumors have less diffusion of water due to increased cellularity, more macromolecular proteins and less extracellular space and hence lower apparent diffusion coefficient [22]. Nomori et al reported lower rate of false positives (FPs) and a higher accuracy of diffusion-weighted imaging MRI as compared with PET-CT in mediastinal staging of NSCLC [23], but these results have not been replicated by others [24]. Further work is needed to determine whether this technology will be useful in routine mediastinal staging of NSCLC.…”

Section: Mrimentioning

confidence: 99%

Mediastinal staging of non-small-cell lung cancer

Dhillon

Yendamuri

2011

Expert Review of Respiratory Medicine

View full text Add to dashboard Cite

Diffusion-weighted magnetic resonance imaging can be used in place of positron emission tomography for N staging of non–small cell lung cancer with fewer false-positive results

Abstract: Diffusion-weighted magnetic resonance imaging can be used in place of positron emission tomography-computed tomography for N staging of non-small cell lung cancer with fewer false-positive results compared with positron emission tomography-computed tomography.

Cited by 143 publications

References 19 publications

Diagnostic Performance of Diffusion Weighted Imaging of Malignant and Benign Pulmonary Nodules and Masses: Comparison with Positron Emission Tomography

Diagnostic Performance of Diffusion Weighted Imaging of Malignant and Benign Pulmonary Nodules and Masses: Comparison with Positron Emission Tomography

Diffusion weighted MRI for detecting and monitoring cancer: a review of current applications in body imaging

Mediastinal staging of non-small-cell lung cancer

Contact Info

Product

Resources

About