Diffusion-weighted magnetic resonance imaging of primary cervical cancer in the detection of sub-centimetre metastatic lymph nodes

Perucho, Jose Angelo Udal; Chiu, K.W.; Wong, Esther Man Fung; Tse, Ka Yu; Chu, Mandy Man Yee; Chan, Lawrence; Pang, Herbert; Khong, Pek Lan; Lee, Elaine

doi:10.1186/s40644-020-00303-4

Cited by 6 publications

(7 citation statements)

References 52 publications

(57 reference statements)

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“…4 Based on this revised classification, cross-sectional imaging, especially magnetic resonance imaging (MRI), has a crucial role in determining cervical cancer staging. 3,4,6,[17][18][19] MRI can determine the origin of the mass, the size of the masses more accurately, invasion of the parametrium, pelvic wall, vagina, bladder, ureter, and rectum, and see the presence of lymph node involvement. 5,17,18 In our study, we highlight the importance of T2WI and DWI-ADC sequences in cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

“…3,4,6,[17][18][19] MRI can determine the origin of the mass, the size of the masses more accurately, invasion of the parametrium, pelvic wall, vagina, bladder, ureter, and rectum, and see the presence of lymph node involvement. 5,17,18 In our study, we highlight the importance of T2WI and DWI-ADC sequences in cervical cancer. In T2WI, we can determine if there is tissue edema or necrosis due to cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

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Role of T2-weighted and Diffusion-weighted Imaging in Cervical Malignancy in Developing Countries

Soekersi

Hidayat

Zeindadinanda

et al. 2022

Glob Med Health Commun

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Cervical cancer is the second most common gynecologic malignancy in Asia and is the leading cause of death in women in developing countries. The cervical cancer stage will significantly affect the prognosis and management. Based on the International Federation of Gynecology and Obstetrics (FIGO) 2018 classification of cervical cancer, magnetic resonance imaging (MRI) has a crucial role in determining cervical cancer staging. This study aimed to evaluate the role of T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI) sequences in assessing cervical carcinoma, with the pathological diagnosis being taken as the standard for cervical cancer diagnosis. This study was conducted on seven patients diagnosed with cervical cancer from pathological examination in January 2020 to March 2021 in the Department of Radiology Dr. Hasan Sadikin General Hospital Bandung. We detect the presence of locoregional lesions and extensions of cervical carcinoma using MRI with T2WI and DWI sequences in patients who have previously been diagnosed histopathologically. This study involved seven cervical cancer patients. Pelvic MRI with T2WI and DWI sequences was performed. The imaging results in these patients show that one patient has stage IB1 cervical cancer, four patients have stage IIB, one patient has stage IIIA, and one has stage IIIC1 cervical cancer. This study concluded that T2WI and DWI sequences in MRI are essential and sufficient for diagnosing cervical cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Role of T2-weighted and Diffusion-weighted Imaging in Cervical Malignancy in Developing Countries

Soekersi

Hidayat

Zeindadinanda

et al. 2022

Glob Med Health Commun

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“…et al При выявлении МТЛУ они использовали совокупность критериев: размер ЛУ по короткой оси более 1 см, выявленный на Т2-ВИ, круглая форма ЛУ и наличие сигнала, аналогичного первичной опухоли. По их данным, ДЧ, ДС, ППЗ и НПЗ были очень высокими, коррелировали с результатами исследования с применением специфичного для ЛУ нового препарата ферумокстран-10 и составили 93%, 97%, 59% и 100% на основе ЛУ и 100%, 94%, 82% и 100% на основе пациента [9]. В то же время высокий показатель AUC математической модели -0,876±0,35 свидетельствует в пользу ее высокой прогностической ценности.…”

Section: методunclassified

“…et al, 18 F-ФДГ-ПЭТ/КТ имеет высокую точность в выявлении МТЛУ [7], а также демонстрирует более высокие показатели ДТ, ДЧ и ДС по сравнению с методами визуализации, использующими критерий размера со значимой разницей диагностической информативности (p<0,05) [8]. Однако 18 F-ФДГ-ПЭТ/ КТ имеет значительную лучевую нагрузку, высокую стоимость исследования и ограниченную доступность [9].…”

Section: Introductionunclassified

Comparison of the Possibilities of MRI and PET/CT in Detecting Metastatic Lesion of Lymph Nodes in Cervical Cancer

Жук¹

2023

Евразийский Онкологический Журнал

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Цель. Сравнение возможностей позитронно-эмиссионной томографии, совмещенной с компьютерной томографией (ПЭТ/КТ), и магнитно-резонансной томографии (МРТ) с применением стандартного критерия (размер по короткой оси ≥1,0 см) и математической модели для выявления метастатического поражения лимфатических узлов (ЛУ) при раке шейки матки (РШМ). Материалы и методы. В исследование включены данные 108 пациентов с гистологически подтвержденным диагнозом РШМ, пролеченных хирургическим методом и консервативно, которым для оценки распространенности процесса и результатов лечения выполнены МРТ и ПЭТ/КТ. Для оценки возможностей методов в выявлении метастазов анализу подверглись 220 ЛУ. Данные ПЭТ/КТ и МРТ с применением стандартного критерия и математической модели сравнивали с результатами морфологического исследования резецированных препаратов, а также с данными динамического наблюдения (медиана наблюдения составила 8 месяцев). Для оценки диагностической эффективности методов были построены ROC-кривые (Receiver Operating Characteristic curve – ROC) с расчетом площадей под ними (Area Under Curve – AUC), определены диагностическая чувствительность (ДЧ), диагностическая специфичность (ДС), диагностическая точность (ДТ), позитивное предсказательное значение (ППЗ), негативное предсказательное значение (НПЗ). Результаты. ДЧ и ДТ МРТ математической модели составили 92,0%, 93,2% соответственно, значимо превосходили ДЧ и ДТ МРТ стандартного критерия (59,9% и 74,5% соответственно) (р<0,001) и были статистически сопоставимы с ДЧ и ДТ ПЭТ/КТ 97,8% и 96,8% соответственно) (р>0,05). AUC математической модели 0,936 значимо превосходила AUC стандартного критерия – 0,793 (р<0,05) и была сопоставима с AUC ПЭТ/КТ – 0,965 (р>0,05). Для ЛУ размером меньше 1 см по короткой оси AUC математической модели 0,876 сопоставима с AUC ПЭТ/КТ – 0,948 (р>0,05). Заключение. Математическая модель имеет высокую прогностическую ценность для выявления метастазов в ЛУ, сопоставимую с ПЭТ/КТ в том числе для ЛУ размером по короткой оси меньше 1 см. Purpose. Comparison of the capabilities of Positron Emission Tomography and Computed Tomography (PET/CT) and magnetic resonance imaging (MRI) using a standard criterion (size along the short axis D ≥1.0 cm) and a mathematical model for the detection of metastatic lesions of the lymph nodes (LN) in cervical cancer (CC). Materials and methods. The study included data from 108 patients with a histologically confirmed diagnosis of СС, treated surgically and conservatively, who underwent MRI and PET/CT to assess the prevalence of the tumor and the results of treatment. To assess the capabilities of the methods in detecting metastatic lesions, 220 LNs were analyzed. PET/ CT and MRI data using a standard criterion and a mathematical model were compared with the results of a morphological study of resected preparations, as well as with dynamic follow-up data (median follow-up was 8 months). To assess the diagnostic efficiency of the methods, ROC-curves (Receiver Operating Characteristic curve – ROC) were constructed, with the calculation of the areas under them (Area Under Curve – AUC), sensitivity (Se), specificity (Sp), accuracy, positive predictive value. negative predictive value were determined. Results. Se and accuracy MRI of the mathematical model were 92.0%, 93.2%, respectively, significantly exceeded the Se and accuracy MRI of the standard criterion (59.9% and 74.5%, respectively) and were statistically comparable with Se and accuracy PET/CT (97.8% and 96.8%, respectively). The AUC of the mathematical model was 0.936 significantly exceeded the AUC of the standard criterion 0.793 (p<0.05) and was comparable to the AUC of PET/CT 0.965 (p>0.05). For LNs smaller than 1 cm along the short axis, the AUC of the mathematical model was 0.876 and was also comparable to the PET/CT AUC 0.948 (р>0.05). Conclusion. The mathematical model has a high prognostic value for detecting LN metastases, comparable to PET/CT, including for LNs with a short axis size of less than 1 cm.

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“…The presence of lymph node metastasis in the pelvic cavity was evaluated. Metastatic lymphadenopathy was defined as any enlarged lymph nodes larger than 10 mm in the short-axis diameter on T1-weighted images [10] (Fig. 4).…”

Section: The Utility Of Dw-mri Versus Multiparametric Mri In the Characterization Of The Studied 60 Uterine Cervix Focal Lesionsmentioning

confidence: 99%

The value of the added diffusion-weighted images to multiparametric MRI in the early diagnosis of uterine cervix cancers and nodal assessment

Osman

Mourad

2021

Egypt J Radiol Nucl Med

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Background Cervical cancer still one of the most common causes of tumor-related death in developing countries presented in younger women. In this study, we aimed to evaluate the value of diffusion-weighted MRI in early diagnosis of malignant cervical lesions, to assess metastatic adenopathy, peritoneal dissemination, and possible tumor recurrence, and determine treatment response. This study included 60 patients with abnormal vaginal bleeding and suspected cervical lesion by US. A histopathological biopsy was done. Pelvic MR with DWI and dynamic contrast-enhanced MRI were done for all patients. Results According to the histopathological findings, we divided our studied 60 patents into two groups: group I, malignant lesions (46 lesions; 76.7%), and group II, benign lesions (14 lesions; 23.3%). Multiparametric MRI could detect all cervical lesions but with poor pathologic characterization, achieving 72.37% sensitivity, 37.50% specificity, 63.33% accuracy, 76.19% PPV, and 33.33% NPV. When compared with DWI with ADC value measurements at high b value (b = 800) to MRI exam, it showed a higher diagnostic accuracy with good lesion pathological characterization that achieved 95.65% sensitivity, 71.43% specificity, 90% accuracy, 91.67 PPV, and 83.33% NPV. The mean ADC value for malignant lesions was 0.86–1.1, mean = 0.92 ± 0.71 × 10−3 mm2/s, while the mean ADC value in the benign lesion group was 1.18 ± 0.1 × 10–3 mm2/s. Conclusion Comparing DWI with ADC values measurements at high b value to the multiparametric MRI examination of the female pelvis increases the sensitivity, specificity, and diagnostic accuracy of characterization and early diagnosis of cervical malignant focal lesions and reduces the need for intravenous contrast administration.

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Diffusion-weighted magnetic resonance imaging of primary cervical cancer in the detection of sub-centimetre metastatic lymph nodes

Cited by 6 publications

References 52 publications

Role of T2-weighted and Diffusion-weighted Imaging in Cervical Malignancy in Developing Countries

Role of T2-weighted and Diffusion-weighted Imaging in Cervical Malignancy in Developing Countries

Comparison of the Possibilities of MRI and PET/CT in Detecting Metastatic Lesion of Lymph Nodes in Cervical Cancer

The value of the added diffusion-weighted images to multiparametric MRI in the early diagnosis of uterine cervix cancers and nodal assessment

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