Diffusion‐weighted MR imaging and apparent diffusion coefficient of the normal fetal lung: preliminary experience

Manganaro, Lucia; Perrone, Anna; Sassi, Simona; Fierro, Francesca; Savelli, Sara; Maurizio, Marco Di; Tomei, Alessandra; Francioso, A.; Barbera, Laura La; Giancotti, Antonella; Ballesio, Laura

doi:10.1002/pd.2041

Cited by 32 publications

(18 citation statements)

References 23 publications

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“…Cannie et al (10) showed that ADC calculated from low b-values (b=0, 100, 250) showed a high correlation with gestational age, whereas ADC calculated from high b-values (b=500, 750, 1000) showed an inverse correlation with gestational age. In a similar study, Manganero et al (11) showed high correlation between gestational age and ADC when 3 b-values were acquired (b=0, 250, 750). Thus a consensus has yet to be achieved in the literature on the appropriate acquisition protocol to be used for reliable ADC estimation for fetal lungs.…”

Section: Introductionmentioning

confidence: 63%

Fetal lung apparent diffusion coefficient measurement using diffusion-weighted MRI at 3 Tesla: Correlation with gestational age

Afacan

Gholipour

Mulkern

et al. 2016

J. Magn. Reson. Imaging

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Purpose To evaluate the feasibility of using diffusion-weighted magnetic resonance imaging (DW-MRI) to assess the fetal lung Apparent Diffusion Coefficient (ADC) at 3T. Materials and Methods 71 pregnant women (32 second trimester, 39 third trimester) were scanned with a twice-refocused Echo-planar diffusion-weighted imaging sequence with 6 different b-values in 3 orthogonal diffusion orientations at 3T. After each scan, a Region-of-Interest (ROI) mask was drawn to select a region in the fetal lung and an automated robust maximum likelihood estimation algorithm was used to compute the ADC parameter. The amount of motion in each scan was visually rated. Results When scans with unacceptable levels of motion were eliminated, the lung ADC values showed a strong association with gestational age (p<0.01), increasing dramatically between 16 and 27 weeks and then achieving a plateau around 27 weeks. Conclusions We show that in order to get reliable estimates of ADC values of fetal lungs, a multi b-value acquisition, where motion is either corrected or considered, can be performed.

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Section: Introductionmentioning

confidence: 63%

Fetal lung apparent diffusion coefficient measurement using diffusion-weighted MRI at 3 Tesla: Correlation with gestational age

Afacan

Gholipour

Mulkern

et al. 2016

J. Magn. Reson. Imaging

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“…[2,3,[9][10][11][12] Its systematic use could help to identify in many cases the nature of the fetal problem and to predict the risk of stillbirth [10,11] , as a complementary to other sophisticated research methods. [13][14][15][16][17] This would be very important in order to try to prevent stillbirth itself, an event that too often remains unexplained even today.…”

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confidence: 99%

Fetal biparametric MR imaging in the diagnosis of congenital mesoblastic nephroma

Manganaro

Bernardo

Antonelli

et al. 2018

Turkish Journal of Urology

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“…A high b factor of 700 s/mm 2 was employed in this study. In another 2008 article (125) a highly correlated increase of ADC with GA was measured using EPI-DWI in 50 fetuses, deemed to have normal lung development, from 18 to 36 weeks GA. An impressive Pearson correlation figure from the linear regression of ADC vs. GA, r=0.816, was reported. The positive slope of ADC with GA was not explicitly provided but from the scatterplot and accompanying Table, a linear growth of ADC from around 1.6 to 3.5 μm 2 /ms appears to occur over the 18 to 35 week GA range.…”

Section: Technique Reviewmentioning

confidence: 99%

Fetal MRI: A technical update with educational aspirations

Gholipour

Estroff

Barnewolt

et al. 2014

Concepts Magnetic Resonance

100

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Fetal magnetic resonance imaging (MRI) examinations have become well-established procedures at many institutions and can serve as useful adjuncts to ultrasound (US) exams when diagnostic doubts remain after US. Due to fetal motion, however, fetal MRI exams are challenging and require the MR scanner to be used in a somewhat different mode than that employed for more routine clinical studies. Herein we review the techniques most commonly used, and those that are available, for fetal MRI with an emphasis on the physics of the techniques and how to deploy them to improve success rates for fetal MRI exams. By far the most common technique employed is single-shot T2-weighted imaging due to its excellent tissue contrast and relative immunity to fetal motion. Despite the significant challenges involved, however, many of the other techniques commonly employed in conventional neuro- and body MRI such as T1 and T2*-weighted imaging, diffusion and perfusion weighted imaging, as well as spectroscopic methods remain of interest for fetal MR applications. An effort to understand the strengths and limitations of these basic methods within the context of fetal MRI is made in order to optimize their use and facilitate implementation of technical improvements for the further development of fetal MR imaging, both in acquisition and post-processing strategies.

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Diffusion‐weighted MR imaging and apparent diffusion coefficient of the normal fetal lung: preliminary experience

Abstract: The ADC values correlate with gestational age since alveolar fluid secretion and angiogenesis increase gradually. Therefore, ADC can be considered as a new parameter for studying lung maturity.

Cited by 32 publications

References 23 publications

Fetal lung apparent diffusion coefficient measurement using diffusion-weighted MRI at 3 Tesla: Correlation with gestational age

Fetal lung apparent diffusion coefficient measurement using diffusion-weighted MRI at 3 Tesla: Correlation with gestational age

Fetal biparametric MR imaging in the diagnosis of congenital mesoblastic nephroma

Fetal MRI: A technical update with educational aspirations

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