Diffusion-weighted MR imaging of thyroid nodules

Bozgeyik, Zülkif; Coskun, Sonay; Dağlı, Adile Ferda; Özkan, Yusuf; Şahpaz, Fatih; Oğur, Erkin

doi:10.1007/s00234-008-0494-3

Cited by 65 publications

(58 citation statements)

References 21 publications

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“…Recently, ADC value has shown potential as a surrogate imaging biomarker to assess tumor aggressiveness in breast (15), prostate (16)(17)(18), and rectal cancers (19). For thyroid cancers, DW-MRI has been applied in the assessment of thyroid nodules, especially for the differentiation of benign and malignant tumors (20)(21)(22)(23)(24)(25)(26)(27). The purpose of this study was to evaluate whether ADC calculated from DW-MRI data before surgery stratifies tumor aggressiveness as defined at surgical histopathology analysis in PTCs.…”

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confidence: 99%

Using Diffusion-Weighted MRI to Predict Aggressive Histological Features in Papillary Thyroid Carcinoma: A Novel Tool for Pre-Operative Risk Stratification in Thyroid Cancer

Moreira

Hatzoglou

et al. 2015

Thyroid

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Background: Initial management recommendations of papillary thyroid carcinoma (PTC) are very dependent on preoperative studies designed to evaluate the presence of PTC with aggressive features. The purpose of this study was to evaluate whether diffusion-weighted magnetic resonance imaging (DW-MRI) before surgery can be used as a tool to stratify tumor aggressiveness in patients with PTC. Methods: In this prospective study, 28 patients with PTC underwent DW-MRI studies on a three Tesla MR scanner prior to thyroidectomy. Due to image quality, 21 patients were finally suitable for further analysis. Apparent diffusion coefficients (ADCs) of normal thyroid tissues and PTCs for 21 patients were calculated. Tumor aggressiveness was defined by surgical histopathology. The Mann-Whitney U test was used to compare the difference in ADCs among groups of normal thyroid tissues and PTCs with and without features of tumor aggressiveness. Receiver operating characteristic (ROC) analysis was performed to assess the discriminative specificity, sensitivity, and accuracy of and determine the cutoff value for the ADC in stratifying PTCs with tumor aggressiveness. Results: There was no significant difference in ADC values between normal thyroid tissues and PTCs. However, ADC values of PTCs with extrathyroidal extension (ETE; 1.53 -0.25 · 10 -3 mm 2 /s) were significantly lower than corresponding values from PTCs without ETE (2.37 -0.67 · 10 -3 mm 2 /s; p < 0.005). ADC values identified 3 papillary carcinoma patients with extrathyroidal extension that would have otherwise been candidates for observation based on ultrasound evaluations. The cutoff value of ADC to discriminate PTCs with and without ETE was determined at 1.85 · 10 -3 mm 2 /s with a sensitivity of 85%, specificity of 85%, and ROC curve area of 0.85. Conclusion: ADC value derived from DW-MRI before surgery has the potential to stratify ETE in patients with PTCs.

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confidence: 99%

Using Diffusion-Weighted MRI to Predict Aggressive Histological Features in Papillary Thyroid Carcinoma: A Novel Tool for Pre-Operative Risk Stratification in Thyroid Cancer

Moreira

Hatzoglou

et al. 2015

Thyroid

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“…Consideramos que la RM tiene potencial para una mejor caracterización de dichas lesiones que probablemente vengan de la mano de los estudios de RM avanzada que utilizan protocolos de valoración funcional. Las imágenes de difusión (DWI) pueden ser útiles para diferenciar los nódulos benignos y malignos [18][19][20]. En recientes estudios observamos que los nódulos benignos tienen mayor coeficiente de difusión aparente (ADC), que los valores de los malignos.…”

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“…La presencia de picos de colina es posible identificarla en casi todos los carcinomas, además de la valoración de la proporción de colina/creatina, que va desde valores de 1,6 en los carcinomas diferenciados, a valores de 9,4 en los carcinomas anaplásicos. El tejido tiroideo normal y lesiones foliculares benignas generalmente no demuestran ningún pico de colina [21][22][23]. CONCLUSIONES La exploración tiroidea ha mejorado desde la introducción de nuevas técnicas ecográficas, gammagráficas, TC, RM y el desarrollo de fusión de imágenes.…”

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Resonancia magnética de tiroides y paratiroides

et al. 2017

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“…12 They used b values of 0 and 1000 s / mm ² to obtain DWI and found similar results for malignant nodules with Razek et al Another study performed by Bozgeyik Z et al included 88 benign and 5 malignant thyroid nodules. 17 They used b factors of 100, 200 and 300 s / mm² for ADC measurements. The mean ADC values of malignant and benign nodules were 0.96 ± 0.65 x 10¯³ mm² /s and 3.06±0.71 x 10¯³ mm² / s for b-100 factor, 0.56 ± 0.43 x 10¯³ mm² / s and 1.80 ± 0.60 x 10¯³ mm² / s for b-200 factor, and 0.30 ± 0.20 x 10¯³ mm² / s and 1.15 ± 0.43 x 10¯³ mm² / s for b-300 factor, respectively.…”

Section: Discussionmentioning

confidence: 99%

ADC Values in Distinction of Benign and Malignant Thyroid Nodules

Halefoğlu¹,

Özçağlayan²,

Özel³

et al. 2017

World Clin J Med Sci

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World Clin J Med Sci 2017;1(2): [96][97][98][99][100][101][102] 96 he prevalence of the thyroid nodules in general population is fairly high. They can be detected with manual palpation in 4% -7%.1,2 On ultrasound examination (USG) in 10% -40%, and by pathological examination at autopsy in 50%. 3,4 Thyroid nodules are more frequently seen in adults and women.5 Their importance is primarly related to necessity of excluding a thyroid malignancy. 6 Fortunately, compared with high prevalence of thyroid nodules, malignancy is rare.In recent studies USG characteristics were evaluated in terms of potential feature of thyroid cancers. 7,8 In spite of presence of well known sonographic data, there is still an overlap in the appearance of these features. 8,9 Nuclear scintigraphy has risk of radiation exposure and not all hot or hyperfunctioning nodules detected on scintigraphy are benign.10,11 Malignancy risk for cold nodule is four times more common compared with a hot nodüle. 3,10The importance of conventional magnetic resonance imaging (MRI)

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Diffusion-weighted MR imaging of thyroid nodules

Abstract: Benign nodules have higher ADC values than malignant ones. DWI may be helpful in differentiating malign and benign thyroid nodules.

Cited by 65 publications

References 21 publications

Using Diffusion-Weighted MRI to Predict Aggressive Histological Features in Papillary Thyroid Carcinoma: A Novel Tool for Pre-Operative Risk Stratification in Thyroid Cancer

Using Diffusion-Weighted MRI to Predict Aggressive Histological Features in Papillary Thyroid Carcinoma: A Novel Tool for Pre-Operative Risk Stratification in Thyroid Cancer

Resonancia magnética de tiroides y paratiroides

ADC Values in Distinction of Benign and Malignant Thyroid Nodules

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