Diffusion-weighted MRI of metastatic liver lesions: is there a difference between hypervascular and hypovascular metastases?

Schmid-Tannwald, Christine; Thomas, Stephen; Ivancevic, Marko K.; Dahi, Farid; Rist, Carsten; Sethi, Ila; Oto, Aytekin

doi:10.1177/0284185113501493

Cited by 10 publications

(6 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DWI is a good functional technique for the detection of PanNET liver metastases, with 71% sensitivity and 85%-100% specificity, equal or even higher than T2-weighted and contrast-enhanced images [62,63] . In a study that evaluated the role of DWI in the differentiation of hemangiomas from other hypervascular liver lesions, the mean ADC value of NETs metastases was found to be 1.43 × 10 -3 ± 0.39 × 10 -3 mm 2 /s [64] , slightly higher than that reported by Schmid-Tannwald (1.23 × 10 -3 ± 0.31 × 10 -3 mm 2 /s) [65] . Nevertheless, MR features derived from conventional sequences should be always taken into account, due to a wide overlap in ADC values among different liver lesions.…”

Section: Pancreatic Tumorsmentioning

confidence: 56%

Prognostication and response assessment in liver and pancreatic tumors: The new imaging

Robertis¹,

Martini²,

Demozzi³

et al. 2015

WJG

View full text Add to dashboard Cite

Diffusion-weighted imaging (DWI), dynamic contrastenhanced magnetic resonance imaging (DCE-MRI) and perfusion computed tomography (CT) are technical improvements of morphologic imaging that can evaluate functional properties of hepato-bilio-pancreatic tumors during conventional MRI or CT examinations. Nevertheless, the term "functional imaging" is commonly used to describe molecular imaging techniques, as positron emission tomography (PET) CT/MRI, which still represent the most widely used methods for the evaluation of functional properties of solid neoplasms; unlike PET or single photon emission computed tomography, functional imaging techniques applied to conventional MRI/CT examinations do not require the administration of radiolabeled drugs or specific equipments. Moreover, DWI and DCE-MRI can be performed during the same session, thus providing a comprehensive "one-step" morphological and functional evaluation of hepato-bilio-pancreatic tumors. Literature data reveal that functional imaging techniques could be proposed for the evaluation of these tumors before treatment, given that they may improve staging and predict prognosis or clinical outcome. Microscopic changes within neoplastic tissues induced by treatments can be detected and quantified with functional imaging, therefore these techniques could be used also for posttreatment assessment, even at an early stage. or altered cellular membranes will present diffusion restriction, which is depicted as signal hyperintensity areas on high b-value DW images and hypointensity on the apparent diffusion coefficient (ADC) maps; ADC measurement can also quantify water molecules' diffusion. As dedifferentiation or therapies may induce microscopic changes in neoplastic tissues that could modify water molecules' diffusion, DWI can distinguish between different degrees of malignancy and can be also proposed for post-treatment monitoring. Moreover, DWI can be performed in a single session with DCE-MRI, thus providing a comprehensive "one-step" morphological and functional evaluation of hepatobilio-pancreatic tumors.Perfusion imaging techniques evaluate changes in signal intensity (DCE-MRI) or density (pCT) after contrast medium injection, being therefore able to assess microvascularization through the evaluation of the dynamics of contrast medium distribution from vessels to the neoplastic tissue. Perfusion parameters are therefore theoretically good candidates for the evaluation of microscopic vascular differences between lesions with different pathological grade and for the assessment of treatment response, especially after chemoembolization or during treatments with antiangiogenic drugs.This editorial analyzes up-to-date literature data regarding the application of functional imaging techniques, apart from molecular imaging, to hepatic and pancreatic tumors, with particular emphasis on correlations to pathological features, prognostic stratification and therapeutic response assessment. FUNCTIONAL IMAGING TECHNIQUES: TECHNICAL BASESIn 1965 Stejskal and Tanne...

show abstract

Section: Pancreatic Tumorsmentioning

confidence: 56%

Prognostication and response assessment in liver and pancreatic tumors: The new imaging

Robertis¹,

Martini²,

Demozzi³

et al. 2015

WJG

View full text Add to dashboard Cite

show abstract

“…Imaging criteria for benign hypervascular lesions consisted of arterial contrast enhancement and washout on delayed images. For benign hypovascular lesions imaging features were deﬁned as delayed enhancement of the venous phase, which had no obvious enhancement on the arterial phase ( 18 ).…”

Section: Methodsmentioning

confidence: 99%

Differential diagnostic value of computed tomography perfusion combined with vascular endothelial growth factor expression in head and neck lesions

et al. 2016

View full text Add to dashboard Cite

There are numerous types of head and neck lesions (HNLs), and conventional computed tomography (CT) has low specificity and sensitivity in the definitive and differential diagnosis of HNLs. The aim of the present study was to evaluate the value of perfusion CT (CTP) combined with vascular endothelial growth factor (VEGF) expression in the differentiation between malignant and benign HNLs. In total, 41 HNLs, which were pathologically confirmed, underwent CTP and VEGF expression analysis. All lesions were divided into three groups: Group A, benign hypovascular lesions; Group B, benign hypervascular lesions; and Group C, malignant lesions. Time density curve (TDC) and CTP parameters [maximum intensity projection (MIP), blood volume (BV), blood flow (BF), mean transit time and capillary permeability] were analyzed. The association between perfusion measurements and VEGF was assessed using Pearson's correlation. TDCs were classified into three types, and type I was more frequently identified in benign tumors (Groups A and B) compared with malignant tumors (Group C) (P=0.003). Malignant tumors primarily had a TDC of type II and III. MIP, BF and BV were all significantly higher in Groups B and C compared to Group A (P<0.01). VEGF expression of malignant tumors was significantly higher than benign tumors (P=0.007). No correlation was identified between VEGF and any CTP parameter. The present findings suggest that CTP combined with VEGF may differentiate between malignant and benign HNLs, and between benign hypovascular and hypervascular lesions.

show abstract

“…Together with T2-weighted imaging and DCE MR perfusion, DWI has been part of PI-RADS since 2010. Detection of malignant neoplasms or metastases in practically any part of the body benefits from DWI, as the following few examples from Acta Radiologica illustrate: pancreas (166,167), liver (168,169), lung (170,171), breast (172,173), head and neck (174,175), and lymph nodes (176).…”

Section: Diffusion-weighted Imagingmentioning

confidence: 99%

The history of magnetic resonance imaging and its reflections in Acta Radiologica

Smith

2021

Acta Radiol

View full text Add to dashboard Cite

The first reports in Acta Radiologica on magnetic resonance imaging (MRI) were published in 1984, four years after the first commercial MR scanners became available. For the first two years, all MR papers originated from the USA. Nordic contributions started in 1986, and until 2020, authors from 44 different countries have published MR papers in Acta Radiologica. Papers on MRI have constituted, on average, 30%–40% of all published original articles in Acta Radiologica, with a high of 49% in 2019. The MR papers published since 1984 document tremendous progress in several areas such as magnet and coil design, motion compensation techniques, faster image acquisitions, new image contrast, contrast-enhanced MRI, functional MRI, and image analysis. In this historical review, all of these aspects of MRI are discussed and related to Acta Radiologica papers.

show abstract

Diffusion-weighted MRI of metastatic liver lesions: is there a difference between hypervascular and hypovascular metastases?

Cited by 10 publications

References 23 publications

Prognostication and response assessment in liver and pancreatic tumors: The new imaging

Prognostication and response assessment in liver and pancreatic tumors: The new imaging

Differential diagnostic value of computed tomography perfusion combined with vascular endothelial growth factor expression in head and neck lesions

The history of magnetic resonance imaging and its reflections in Acta Radiologica

Contact Info

Product

Resources

About