Diffusion-weighted MRI to detect early response to chemoradiation in cervical cancer: A systematic review and meta-analysis

Harry, Vanessa N.; Persad, Sunil; Bassaw, B; Parkin, David E.

doi:10.1016/j.gore.2021.100883

Cited by 14 publications

(11 citation statements)

References 46 publications

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“…Numerous studies have adopted ADC values in the prognosis of cervical cancer [ 42 ]; however, only some studies reported histogram-derived ADC maps in cervical cancer. An ADC value is influenced by molecular viscosity, membrane permeability, and cell structures, and histogram-derived parameters based on ADC values reflect cell heterogeneity in different physiological states.…”

Section: Discussionmentioning

confidence: 99%

A feasibility study of reduced full-of-view synthetic high-b-value diffusion-weighted imaging in uterine tumors

et al. 2023

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Objectives This study aimed to evaluate the feasibility of reduced full-of-view synthetic high-b value diffusion-weighted images (rFOV-syDWIs) in the clinical application of cervical cancer based on image quality and diagnostic efficacy. Methods We retrospectively evaluated the data of 35 patients with cervical cancer and 35 healthy volunteers from May to November 2021. All patients and volunteers underwent rFOV-DWI scans, including a 13b-protocol: b = 0, 25, 50, 75, 100, 150, 200, 400, 600, 800, 1000, 1200, and 1500 s/mm2 and a 5b-protocol: b = 0, 100, 400, 800,1500 s/mm2. rFOV-syDWIs with b values of 1200 (rFOV-syDWIb=1200) and 1500 (rFOV-syDWIb=1500) were generated from two different multiple-b-value image datasets using a mono-exponential fitting algorithm. According to homoscedasticity and normality assessed by the Levene’s test and Shapiro–Wilk test, the inter-modality differences of quantitative measurements were, respectively, examined by Wilcoxon signed-rank test or paired t test and the inter-group differences of ADC values were examined by independent t test or Mann–Whitney U test. Results A higher inter-reader agreement between SNRs and CNRs was found in 13b-protocol and 5b-protocol rFOV-syDWIb=1200/1500 compared to 13b-protocol rFOV-sDWIb=1200/1500 (p < 0.05). AUC of 5b-protocol syADCmean,b=1200/1500 and syADCminimum,b=1200/1500 was equal or higher than that of 13b-protocol sADCmean,b=1200/1500 and sADCminimum,b=1200/1500. Conclusions rFOV-syDWIs provide better lesion clarity and higher image quality than rFOV-sDWIs. 5b-protocol rFOV-syDWIs shorten scan time, and synthetic ADCs offer reliable diagnosis value as scanned 13b-protocol DWIs.

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Section: Discussionmentioning

confidence: 99%

A feasibility study of reduced full-of-view synthetic high-b-value diffusion-weighted imaging in uterine tumors

et al. 2023

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“…4 Based on this revised classification, cross-sectional imaging, especially magnetic resonance imaging (MRI), has a crucial role in determining cervical cancer staging. 3,4,6,[17][18][19] MRI can determine the origin of the mass, the size of the masses more accurately, invasion of the parametrium, pelvic wall, vagina, bladder, ureter, and rectum, and see the presence of lymph node involvement. 5,17,18 In our study, we highlight the importance of T2WI and DWI-ADC sequences in cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

Role of T2-weighted and Diffusion-weighted Imaging in Cervical Malignancy in Developing Countries

Soekersi

Hidayat

Zeindadinanda

et al. 2022

Glob Med Health Commun

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Cervical cancer is the second most common gynecologic malignancy in Asia and is the leading cause of death in women in developing countries. The cervical cancer stage will significantly affect the prognosis and management. Based on the International Federation of Gynecology and Obstetrics (FIGO) 2018 classification of cervical cancer, magnetic resonance imaging (MRI) has a crucial role in determining cervical cancer staging. This study aimed to evaluate the role of T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI) sequences in assessing cervical carcinoma, with the pathological diagnosis being taken as the standard for cervical cancer diagnosis. This study was conducted on seven patients diagnosed with cervical cancer from pathological examination in January 2020 to March 2021 in the Department of Radiology Dr. Hasan Sadikin General Hospital Bandung. We detect the presence of locoregional lesions and extensions of cervical carcinoma using MRI with T2WI and DWI sequences in patients who have previously been diagnosed histopathologically. This study involved seven cervical cancer patients. Pelvic MRI with T2WI and DWI sequences was performed. The imaging results in these patients show that one patient has stage IB1 cervical cancer, four patients have stage IIB, one patient has stage IIIA, and one has stage IIIC1 cervical cancer. This study concluded that T2WI and DWI sequences in MRI are essential and sufficient for diagnosing cervical cancer.

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“…For example, a study by Law et al (2016) In addition, DWI can provide information on the timing and extent of treatment response, allowing for early modification of treatment plans if necessary. A study by Harry VN et al (2021) found that DWI was able to detect treatment response as early as 2 weeks after the start of chemoradiotherapy, and was able to predict treatment response with high accuracy. (Harry VN, Persad S, Bassaw B & Parkin D., 2021) Overall, DWI has the potential to play an important role in radiation therapy planning and treatment monitoring for Nasopharyngeal carcinoma patients, and may ultimately improve treatment outcomes and quality of life for these patients.…”

Section: Potential Applications Of Diffusion-weighted Imaging In Radi...mentioning

confidence: 99%

A Review of the Role of DWI in Radiation Therapy Planning and Treatment Response Assessment for NPC Management

Huang

Liao

2023

CRMS

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Nasopharyngeal carcinoma (NPC) is a malignant tumor that occurs in the nasopharynx. Its high incidence rate in certain regions of the world poses a significant challenge for healthcare providers. Imaging plays a crucial role in the diagnosis, treatment, and prognosis of NPC. Among various imaging modalities, diffusion-weighted imaging (DWI) has emerged as a promising technique due to its ability to provide functional information on tissue activity. This paper reviews the principles of DWI, its role in the diagnosis, treatment, and prognosis of NPC, and its potential applications in radiation therapy planning and treatment monitoring. DWI has been shown to have higher sensitivity and specificity for the detection of NPC compared to other imaging modalities. It can aid in the selection of radiation dose and target volumes, and monitor the timing and extent of treatment response. Further research is needed to explore the full potential of DWI in the management of NPC.

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Diffusion-weighted MRI to detect early response to chemoradiation in cervical cancer: A systematic review and meta-analysis

Cited by 14 publications

References 46 publications

A feasibility study of reduced full-of-view synthetic high-b-value diffusion-weighted imaging in uterine tumors

A feasibility study of reduced full-of-view synthetic high-b-value diffusion-weighted imaging in uterine tumors

Role of T2-weighted and Diffusion-weighted Imaging in Cervical Malignancy in Developing Countries

A Review of the Role of DWI in Radiation Therapy Planning and Treatment Response Assessment for NPC Management

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