Diffusion‐weighted multiparametric MRI for monitoring longitudinal changes of parameters in rabbit VX2 liver tumors

Wu, Haibing; Liu, Hui; Liang, Changhong; Zhang, Shuixing; Liu, Zaiyi; Liu, Chunling; Liu, Yubao; Hu, Maoqing; Li, Chuanzi; Mei, Yingjie

doi:10.1002/jmri.25179

Cited by 9 publications

(9 citation statements)

References 43 publications

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“…Contrary to the treated group, moderate correlation was found between f and MVD in the control group. This correlation has been reported in pancreatic tumors in patients, in colorectal tumors in nude mice, and in VX2 liver tumors in rabbits . Hence, we believe f could serve as a noninvasive marker of tumor vascularity in its natural course of development without drug intervention.…”

Section: Discussionsupporting

confidence: 80%

“…This correlation has been reported in pancreatic tumors in patients, 34 in colorectal tumors in nude mice, 35 and in VX2 liver tumors in rabbits. 36 Hence, we believe f could serve as a noninvasive marker of tumor vascularity in its natural course of development without drug intervention. However, no correlation was found between ADC total , D, and NF in the control group as opposed to the treated group.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of antiangiogenic and antiproliferative effects of sorafenib by sequential histology and intravoxel incoherent motion diffusion-weighted imaging in an orthotopic hepatocellular carcinoma xenograft model

Yang

Jiang

et al. 2016

J. Magn. Reson. Imaging

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Evaluation of antiangiogenic and antiproliferative effects of sorafenib by sequential histology and intravoxel incoherent motion diffusion-weighted imaging in an orthotopic hepatocellular carcinoma xenograft model

Yang

Jiang

et al. 2016

J. Magn. Reson. Imaging

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“…ADC value is always greater than D value because of including tissue diffusion and perfusion (25); it is consistent with our results. In addition, the report (26) has shown that when the b value is chosen appropriately, the ADC value can describe the tumor perfusion information. In this study, no significant correlation was found between ADC value and MVD or VEGF expression; this result was the same as Li et al.…”

Section: Discussionmentioning

confidence: 99%

“…The f value is a substitute marker of blood volume and can be applied in monitoring the changes in blood vessels because of the reduction with the decrease of blood vessels (26). In our study, no significant correlation was found between f value and MVD or VEGF expression; the conclusion was the same as Li et al.…”

Section: Discussionmentioning

confidence: 99%

Intravoxel incoherent motion diffusion-weighted imaging assessment of microvascular characteristics in the murine embryonal rhabdomyosarcoma model

et al. 2019

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Background Intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) can distinguish the false diffusion generated by microvascular blood flow from the true water molecule diffusion. Purpose To investigate the correlation between IVIM-DWI parameters and angiogenic markers such as the microvessel density and vascular endothelial growth factor (VEGF) expression in the murine embryonal rhabdomyosarcoma model. Material and Methods The murine embryonal rhabdomyosarcoma model was produced by subcutaneously injecting 107 human embryonal rhabdomyosarcoma cells into the right back of nude mice. The apparent diffusion coefficient (ADC), pseudo-diffusion coefficient (D*), true diffusion coefficient (D), and perfusion fraction (f) were obtained from 22 mice models using IVIM-DWI with b-values of 0, 50, 100, 150, 200, 400, 600, 800, 1000, and 1200 s/mm2. The microvessel density and VEGF expression were obtained by histologic examination. We then compared the correlation between IVIM-DWI parameters and microvessel density and VEGF expression. Results The average ADC, D*, D, and f values were 1.05 ± 0.27 × 10−3 mm2/s, 6.19 ± 1.78 × 10−3 mm2/s, 0.69 ± 0.09 ×10−3 mm2/s, and 17.68 ± 8.41 (%), respectively. There was moderate positive correlation between D* value and microvessel density and VEGF expression (r = 0.484, P = 0.023; r = 0.511, P = 0.015). However, there was no significant correlation between ADC, D, and f values and microvessel density and VEGF expression. Conclusion The D* value from IVIM-DWI may be used to evaluate tumor angiogenesis in the murine embryonal rhabdomyosarcoma model.

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“…However, the K trans and ADC continued to change 2 weeks after implantation in the current study. A previous study reported that certain diffusion MRI parameters (including ADC) may continue to change within the first month of tumor implantation ( 28 ). Therefore, the K trans and ADC changes reflect the tumor angiogenesis and tumor celluarity, which may be the result of tumor physiological indicators and thus, may occur later than the changes in physiological indicators.…”

Section: Discussionmentioning

confidence: 99%

Dynamics of angiogenesis and cellularity in rabbit VX2 tumors using contrast-enhanced magnetic resonance imaging and diffusion-weighted imaging

Wang

et al. 2017

Oncol Lett

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A number of studies have demonstrated that dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) may be used to evaluate microvessel density (MVD), and may quantitatively reflect tumor angiogenesis. To investigate the dynamics, including angiogenesis and tumor cellularity, of rabbit VX2 tumors during the 4 weeks following tumor implantation, the present study used DCE-MRI combined with diffusion-weighted imaging (DWI) to scan the tumors at 3 days, and then at 1, 2, 3 and 4-week intervals, following tumor implantation. The dynamics, volume transfer coefficient (Ktrans) and apparent diffusion coefficient (ADC) of the tumor parenchyma were analyzed. Furthermore, the associations between Ktrans and MVD at 4 weeks after tumor implantation were analyzed. Tumor Ktrans was positively correlated with MVD at 4 weeks (r=0.674, P<0.001). Following tumor implantation, the tumor Ktrans level rose for 2 weeks and then began to decline, reaching its lowest point at 4 weeks (P<0.001). ADC values at 1 week were higher than at 3 days, but declined thereafter (P<0.001). Tumor necrosis appeared by 1 week after tumor implantation. The necrosis degree of tumor was gradually increased from the occurrence of necrosis within the 4-week time span of the present study (1 vs. 2 weeks, P=0.008; 2 vs. 3 weeks, P<0.001; 3 vs. 4 weeks, P<0.001). The present study identified that tumor angiogenesis is a dynamic process that serves a function in tumor growth, and that DCE-MRI may reflect tumor parenchymal MVD and be useful in evaluating angiogenesis.

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Diffusion‐weighted multiparametric MRI for monitoring longitudinal changes of parameters in rabbit VX2 liver tumors

Abstract: ADC, f, and KDKI were identified as the most promising parameters for monitoring changes in rabbit liver VX2 carcinoma and f and ADC showed highest correlation with MVD. J. Magn. Reson. Imaging 2016;44:707-714.

Cited by 9 publications

References 43 publications

Evaluation of antiangiogenic and antiproliferative effects of sorafenib by sequential histology and intravoxel incoherent motion diffusion-weighted imaging in an orthotopic hepatocellular carcinoma xenograft model

Evaluation of antiangiogenic and antiproliferative effects of sorafenib by sequential histology and intravoxel incoherent motion diffusion-weighted imaging in an orthotopic hepatocellular carcinoma xenograft model

Intravoxel incoherent motion diffusion-weighted imaging assessment of microvascular characteristics in the murine embryonal rhabdomyosarcoma model

Dynamics of angiogenesis and cellularity in rabbit VX2 tumors using contrast-enhanced magnetic resonance imaging and diffusion-weighted imaging

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