Diffusionsbildgebung

Determination of Sr2+ mobility in viscous bovine bone marrow by cryo‐time‐of‐flight secondary ion mass spectrometry

“…26 The latter was measured by diffusion-weighted MRI. 49,[58][59][60][61][62] The reason for this assumption is the double positive charge of the strontium ions, which should have an attractive effect on other charged ions in the bone marrow, resulting in a significantly lower, hindered mobility. Therefore, we had used a value of 1 Â 10 À8 cm 2 /s for our calculations.…”

“…When estimating the diffusion coefficient for Sr 2+ in bone marrow in our previous study, we made the assumption that Sr 2+ mobility in bone marrow should be lower than the mobility of the diffusion of Sr 2+ in water as well as of water in bone marrow 26 . The latter was measured by diffusion‐weighted MRI 49,58–62 . The reason for this assumption is the double positive charge of the strontium ions, which should have an attractive effect on other charged ions in the bone marrow, resulting in a significantly lower, hindered mobility.…”

Characterisation of Sr2+mobility in osteoporotic rat bone marrow by cryo-ToF-SIMS and cryo-OrbiSIMS

“…41 Nevertheless, a number of medical studies have determined the apparent diffusion coefficient (ADC) of water in bone marrow non-invasively by diffusion-weighted magnetic resonance imaging (DW-MRI). 38,[68][69][70][71][72] It has to be noted that, although the ADC is usually given in square millimeters per second, 73 we have converted the values to square centimeters per second for better comparison (see Table S8 †). Water movement in biological tissue is mainly influenced by microscopic cellular tissue structures (e.g., intra-and extracellular macro-molecules, cell membranes, cell organelles, fibres).…”