Diffusivity mapping of the ovaries: Variability of apparent diffusion and kurtosis variables over the menstrual cycle and influence of oral contraceptives

Mokry, Theresa; Mlynarska-Bujny, Anna; Hasse, Felix Christian; Kuder, Tristan Anselm; Kauczor, Hans‐Ulrich; Rom, Joachim; Bickelhaupt, Sebastian

doi:10.1016/j.mri.2021.04.006

Cited by 1 publication

(1 citation statement)

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“…Another key limitation to acknowledge is the current limited availability of empirical data describing the relationships among an individual's inflammatory milieu, HIV-related physiological changes, and multimorbidity on AMH, which may be important considerations for studying the relationships among AMH and symptoms in this patient population (Merlini et al, 2021; Scherzer et al, 2015). Furthermore, cross-sectional study designs cannot adequately assess any contemporaneous associations between estrogen exposure and symptoms over time—which may be very important based on the ways in which physiological responses to estrogen have limited temporal stability (Ballot et al, 2022; Hurwitz et al, 2022; Mokry et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Symptoms, Lifetime Duration of Estrogen Exposure, and Ovarian Reserve Among Women Living With HIV: A Cross-Sectional Observational Study

Moore,

Davey,

Morgan

et al. 2024

J Assoc Nurses AIDS Care

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This cross-sectional observational study examined associations among symptom burden, lifetime duration of estrogen exposure, and serum antimüllerian hormone (AMH) levels among women living with HIV (n = 98) using bivariate bias-corrected Pearson correlations and multiple correspondence analyses. The mostly Black (85.6%) sample of women, with a mean age of 50 years (SD 12.6 years), exhibited no significant reproductive history factors and symptom burden interrelationships or significant associations between lifetime duration of estrogen exposure and symptoms. Predictably, serum AMH levels were lower among older women; however, less predictable were its significant relationships with months living with HIV (r = −0.362), months on ART (r = −0.270), and CD4+ T-cell nadir (r = 0.347). Symptom–symptom relationships support a fatigue, pain, sleep, anxiety, and depression symptom cluster. The hypotheses were not supported by cross-sectional observation. Further studies should explore variation in relationships between HIV, estrogen exposure, ovarian reserve, and AMH levels over time.

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