Diflunisal‐loaded poly(propylene sulfide) nanoparticles decrease <i>S. aureus</i>‐mediated bone destruction during osteomyelitis

Ford, Caleb A.; Spoonmore, Thomas J.; Gupta, Mukesh Kumar; Duvall, Craig L.; Guelcher, Scott A.; Cassat, James E.

doi:10.1002/jor.24948

Cited by 18 publications

(17 citation statements)

References 44 publications

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“…Upon parenteral administration of nanoparticles with diflunisal into mice subjected to osteomyelitis, polymer preferential distributed to infected femurs. There, owning to the inflamed milieu, PPS moiety underwent ROS-mediated oxidation, which resulted in change of core character from hydrophobic to hydrophilic and final release of diflunisal ( Ford et al, 2021 ).…”

Section: Reactive Oxygen Species-sensitive Drug Delivery Systemsmentioning

confidence: 99%

The potential of oxygen and nitrogen species-regulating drug delivery systems in medicine

Sołtan¹,

Bartusik‐Aebisher

Aebisher

2022

Front. Bioeng. Biotechnol.

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The focus of this review is to present most significant advances in biomaterials used for control of reactive oxygen/nitrogen species (ROS/RNS, RONS) in medicine. A summary of the main pathways of ROS production and the main pathways of RNS production are shown herein. Although the physiological and pathological roles of RONS have been known for at least 2decades, the potential of their control in management of disease went unappreciated. Recently, advances in the field of biochemical engineering and materials science have allowed for development of RONS-responsive biomaterials for biomedical applications, which aim to control and change levels of reactive species in tissue microenvironments. These materials utilize polymers, inorganic nanoparticles (NPs), or organic-inorganic hybrids. Thus, biomaterials like hydrogels have been developed to promote tissue regeneration by actively scavenging and reducing RONS levels. Their promising utility comes from thermo- and RONS-sensitivity, stability as a delivery-medium, ease for incorporation into other materials and facility for injection. Their particular attractiveness is attributed to drug release realized in targeted tissues and cells with elevated RONS levels, which leads to enhanced treatment outcomes and reduced adverse effects. The mechanism of their action depends on the functional groups employed and their response to oxidation, and may be based on solubility changes or cleavage of chemical bonds. When talking about antioxidants, one should also mention oxidative stress, which we call the imbalance between antioxidants and reactive oxygen species, which occurs due to a deficiency of endogenous antioxidants and a low supply of exogenous antioxidants. This study is a review of articles in English from the databases PubMed and Web of Science retrieved by applying the search terms “Oxygen Species, Nitrogen Species and biomaterials” from 1996 to 2021.

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Section: Reactive Oxygen Species-sensitive Drug Delivery Systemsmentioning

confidence: 99%

The potential of oxygen and nitrogen species-regulating drug delivery systems in medicine

Sołtan¹,

Bartusik‐Aebisher

Aebisher

2022

Front. Bioeng. Biotechnol.

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“…Thus, Caleb A. Ford et al [23] used diflunisal-loaded nanoparticles based on poly(propylene sulfide), which were obtained by the oil-in-water emulsion method. The authors used two methods to fabricate polymer nanoparticles: a solvent evaporation technique to improve diflunisal loading parameters and a microhydrodynamics method to enhance nanoparticle product yield (for in vivo experiments).…”

Section: Nanoparticlesmentioning

confidence: 99%

“…These authors previously demonstrated [24] that poly(propylene sulfide) nanoparticles represent a reactive oxygen species-responsive drug nanocarrier for delivery of the Gli2 inhibitor, GANT58, to the targeted metastases in bone cancer. It was discussed that poly(propylene sulfide)-based biocarriers could be degraded in the presence of high levels of reactive oxygen species (ROS) and provide drug release at the target tissues and organs [23]. The cumulative release of diflunisal from poly(propylene sulfide) nanoparticles depending on different concentrations of the oxygen-derived radicals H 2 O 2 is shown in Figure 3.…”

Section: Nanoparticlesmentioning

confidence: 99%

Diflunisal Targeted Delivery Systems: A Review

et al. 2021

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Diflunisal is a well-known drug for the treatment of rheumatoid arthritis, osteoarthritis, primary dysmenorrhea, and colon cancer. This molecule belongs to the group of nonsteroidal anti-inflammatory drugs (NSAID) and thus possesses serious side effects such as cardiovascular diseases risk development, renal injury, and hepatic reactions. The last clinical data demonstrated that diflunisal is one of the recognized drugs for the treatment of cardiac amyloidosis and possesses a survival benefit similar to that of clinically approved tafamidis. Diflunisal stabilizes the transthyretin (TTR) tetramer and prevents the misfolding of monomers and dimers from forming amyloid deposits in the heart. To avoid serious side effects of diflunisal, the various delivery systems have been developed. In the present review, attention is given to the recent development of diflunisal-loaded delivery systems, its technology, release profiles, and effectiveness.

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“…Specifically, techniques such as in vivo BLI can be used in conjunction with bacteria that have been genetically modified to express the lux operon ( e.g. , Xen strains) such that the extent of the infection can be imaged in real time. ,, Additionally, the extent of infection remaining can be evaluated at the termination of the study through removal of the material and SEM imaging of the morphology of the bacterial biofilm and CFU counts of adherent bacteria. ,,,,,,,, To evaluate the degradation of implanted materials in vivo , the material can be explanted with surrounding subcutaneous tissue at intermediate time points throughout the study and characterized for its morphology using SEM, molecular weight using gel permeation chromatography, glass transition temperature using differential scanning calorimetry, and residual weight. , …”

Section: Evaluating the Efficacy Of Biomaterials To Prevent/treat Imp...mentioning

confidence: 99%

Recent Advances in the Evaluation of Antimicrobial Materials for Resolution of Orthopedic Implant-Associated Infections In Vivo

et al. 2021

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While orthopedic implant-associated infections are rare, revision surgeries resulting from infections incur considerable healthcare costs and represent a substantial research area clinically, in academia, and in industry. In recent years, there have been numerous advances in the development of antimicrobial strategies for the prevention and treatment of orthopedic implant-associated infections which offer promise to improve the limitations of existing delivery systems through local and controlled release of antimicrobial agents. Prior to translation to in vivo orthopedic implant-associated infection models, the properties (e.g., degradation, antimicrobial activity, biocompatibility) of the antimicrobial materials can be evaluated in subcutaneous implant in vivo models. The antimicrobial materials are then incorporated into in vivo implant models to evaluate the efficacy of using the material to prevent or treat implant-associated infections. Recent technological advances such as 3D-printing, bacterial genomic sequencing, and real-time in vivo imaging of infection and inflammation have contributed to the development of preclinical implant-associated infection models that more effectively recapitulate the clinical presentation of infections and improve the evaluation of antimicrobial materials. This Review highlights the advantages and limitations of antimicrobial materials used in conjunction with orthopedic implants for the prevention and treatment of orthopedic implant-associated infections and discusses how these materials are evaluated in preclinical in vivo models. This analysis serves as a resource for biomaterial researchers in the selection of an appropriate orthopedic implant-associated infection preclinical model to evaluate novel antimicrobial materials.

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Diflunisal‐loaded poly(propylene sulfide) nanoparticles decrease S. aureus‐mediated bone destruction during osteomyelitis

Cited by 18 publications

References 44 publications

The potential of oxygen and nitrogen species-regulating drug delivery systems in medicine

The potential of oxygen and nitrogen species-regulating drug delivery systems in medicine

Diflunisal Targeted Delivery Systems: A Review

Recent Advances in the Evaluation of Antimicrobial Materials for Resolution of Orthopedic Implant-Associated Infections In Vivo

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