Digested disorder

2017

This is the 6 th issue of the Digested Disorder series that continues to use only 2 criteria for inclusion of a paper to this digest: The publication date (a paper should be published within the covered time frame) and the topic (a paper should be dedicated to any aspect of protein intrinsic disorder). The current digest issue covers papers published during the second quarter of 2014; i.e., during the period of April, May, and June of 2014. Similar to previous issues, the papers are grouped hierarchically by topics they cover, and for each of the included papers a short description is given on its major findings.

Section: Experimental Approaches For the Analysis Of Intrinsic Disordermentioning

confidence: 99%

“…[1][2][3][4][5] The goal of this series is to provide an unbiased and condensed survey of the literature on intrinsically disordered proteins on a quarterly basis. As in the previous issues, no special filtering was used except to verify the print date, and exclude those papers not related to the topic.…”

Section: Introductionmentioning

confidence: 99%

Quarterly intrinsic disorder digest (April–May–June, 2014)

2017

“…This article continues the Disorder Digest series. [1][2][3][4] The goal of this series is to provide an unbiased and condensed survey of the literature on intrinsically disordered proteins on a quarterly basis. As in the previous issues, no special filtering was used except to verify the print date, and exclude those papers not related to the topic.…”

Section: Introductionmentioning

confidence: 99%

Quarterly intrinsic disorder digest (January-February-March, 2014)

Reddy

2016

This is the 5 th issue of the Digested Disorder series that represents a reader's digest of the scientific literature on intrinsically disordered proteins. We continue to use only 2 criteria for inclusion of a paper to this digest: The publication date (a paper should be published within the covered time frame) and the topic (a paper should be dedicated to any aspect of protein intrinsic disorder). The current digest issue covers papers published during the first quarter of 2014; i.e., during the period of January, February, and March of 2014. Similar to previous issues, the papers are grouped hierarchically by topics they cover, and for each of the included papers a short description is given on its major findings. The goal of this series is to provide an unbiased and condensed survey of the literature on intrinsically disordered proteins on a quarterly basis. As in the previous issues, no special filtering was used except to verify the print date, and exclude those papers not related to the topic. The digest article is structured hierarchically and papers are grouped in several sections: (1) structures of intrinsically disordered proteins (IDPs); (2) functions of IDPs; (3) methods for the IDP analysis; (4) proteomics of IDPs; (5) IDPs and diseases; and (6) IDPs/IDPRs as drugs or drug targets. One should keep in mind that the unambiguous classification of many papers is challenged by the intertwining of the topics they cover.In the 5 th digest of this series, we cover papers published in January, February, and March of 2014. We used the following search term in PubMed: (intrinsically OR natively OR naturally OR inherently) AND (disordered OR unfolded OR unstructured OR denatured) AND (protein OR region OR peptide OR domain) AND ("2014/01" [PPDAT]: "2014/ 03"[PPDAT]), which returned 103 hits. After filtering hits not relevant to the topic, we have covered 94 articles here. Figure 1 represents a word cloud, which shows the most represented words from all the abstracts of papers included in this issue.We also introduce below a new rubric "Spotlight" that specifically emphasize some of the most interesting and important developments in the field of intrinsically disordered proteins during the covered quarter. Spotlight: IDP databases and the rise of the ensemble viewDatabases of experimentally verified IDPs are critical for the development of tools that predict intrinsic disorder, and provide an important data set for the study of IDP functions, motifs and structural behavior. One of the first databases to provide experimental evidence of intrinsic disorder was oddly enough, the Protein Data Bank, where regions of missing electron density in x-ray crystal structures provide an indication of possible disorder. The major databases for IDPs are Disprot 5 and the recently updated IDEAL 6 and the mostly predictor based databases d2p2 7 and MobiDB.8 CONTACT Vladimir N. Uversky

“…[1][2][3] The goal of this series is to provide an unbiased and condensed survey of the literature on intrinsically disordered proteins on a quarterly basis. As in the previous issues, no special filtering was used except to verify the print date, and exclude those papers not related to the topic.…”

Section: Introductionmentioning

confidence: 99%

Digested disorder, Quarterly intrinsic disorder digest (October-November-December, 2013)

Reddy

2015

Self Cite

This is the 4th issue of the Digested Disorder series that represents reader's digest of the scientific literature on intrinsically disordered proteins. The only 2 criteria for inclusion in this digest are the publication date (a paper should be published within the covered time frame) and topic (a paper should be dedicated to any aspect of protein intrinsic disorder). The current digest issue covers papers published during the fourth quarter of 2013; i.e. during the period of October, November, and December of 2013. Similar to previous issues, the papers are grouped hierarchically by topics they cover, and for each of the included paper a short description is given on its major findings.