The nutritive potential of rumen liquor fermented cassava peels (RLFCP) was assessed in rabbit nutrition in an 8 weeks trial. The freshly collected droppings from layers were sundried, ground and mixed at 100 g/kg with ground cassava peels, sprayed with rumen filtrate and fermented for 144 hours. Thereafter, one basal diet was formulated to meet the nutrient requirement of a growing rabbit. The maize content (43 g/100 g) of the basal diet was replaced at 0, 25, 50, 75 and 100 % with RLFCP and named as diets 1, 2, 3, 4 and 5 respectively. One hundred and fifty mixed sexes healthy 5-weeks old crossbred weaner rabbits were randomly distributed among the five dietary treatments at a rate of 30 rabbits per treatment. The response criteria were growth indices, cost benefit, carcass and organ weight, blood and serum indices. While the average daily feed intake increased (49.27-58.00 g/rabbit/day) with an increased RLFCP inclusion, the average daily weight gain only increased (12.38-17.75 g/rabbit per day) when the increased RLFCP inclusion reached up to a 50 %. The feed conversion ratio of rabbits fed on the control and those fed on 25 % and 50 % RLFCP was similar (3.03-3.20) (p>0.05). Only the slaughtered weight (1116.50-1416.16 g), dressed weight (477.65-695.85 g), dressing % (42.77-50.14), relative weight (% slaughter weight) of the liver (2.18-2.57) and heart (0.20-0.23) were significantly (p