Digestion and Absorption

Johnson, Leonard R.

doi:10.1016/b978-0-323-03391-6.50015-7

Cited by 12 publications

(44 citation statements)

References 8 publications

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“…Long-chain fatty acids and their glycerides are well known to be transported to the lymphatic system after absorbed from the small intestine (29). It was also reported that lipids with long-chain fatty acids promote the transport of drugs into the lymphatic system more effectively than those with short-and/or medium-chain fatty acids (15)(16)(17).…”

Section: Preparation Of Lc-snedds Formulationmentioning

confidence: 98%

Improvement of Oral Bioavailability of N-251, a Novel Antimalarial Drug, by Increasing Lymphatic Transport with Long-Chain Fatty Acid-Based Self-Nanoemulsifying Drug Delivery System

et al. 2015

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Section: Preparation Of Lc-snedds Formulationmentioning

confidence: 98%

Improvement of Oral Bioavailability of N-251, a Novel Antimalarial Drug, by Increasing Lymphatic Transport with Long-Chain Fatty Acid-Based Self-Nanoemulsifying Drug Delivery System

et al. 2015

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“…The pancreatic juices secreted into the small intestine contain trypsin, chymotryspin, elastases and lipases, along with other enzymes that work to deconstruct the protein. Additionally, membrane-bound enzymes like peptidases are present on the small intestinal brush border (Johnson, 2001). …”

Section: Barriers To Oral Drug Deliverymentioning

confidence: 99%

Impact of absorption and transport on intelligent therapeutics and nanoscale delivery of protein therapeutic agents

Peppas

Carr

2009

Chemical Engineering Science

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The combination of materials design and advances in nanotechnology has led to the development of new therapeutic protein delivery systems. The pulmonary, nasal, buccal and other routes have been investigated as delivery options for protein therapy, but none result in improved patient compliances and patient quality of life as the oral route. For the oral administration of these new systems, an understanding of protein transport is essential because of the dynamic nature of the gastrointestinal tract and the barriers to transport that exist.Models have been developed to describe the transport between the gastrointestinal lumen and the bloodstream, and laboratory techniques like cell culture provide a means to investigate the absorption and transport of many therapeutic agents. Biomaterials, including stimuli-sensitive complexation hydrogels, have been investigated as promising carriers for oral delivery. However, the need to develop models that accurately predict protein blood concentration as a function of the material structure and properties still exists.

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“…Dietary lipids, such as TAGs, must pass across the intestinal membrane for absorption. There are four events that must occur for TAGs to be assimilated: 1) secretion of bile and lipases, 2) emulsification, 3) enzymatic hydrolysis of ester linkages, and 4) solubilization of lipolytic products within bile salt micelles ( Figure 2) (Johnson, 2001). Lipid digestion begins in the stomach; this process consists primarily of absorption of short chain fatty acids that are membrane permeable and water soluble.…”

Section: Dietary Fatty Acid Absorptionmentioning

confidence: 99%

“…CCK causes gastric motility to slow, secretion of lipases, and contraction of the gallbladder. Gastric lipases are secreted by the fundus portion of the stomach; these lipases hydrolyze TAGs to diacylglycerides (DAG) (Johnson, 2001).…”

Section: Dietary Fatty Acid Absorptionmentioning

confidence: 99%

“…Phospholipase A2 cleaves R2 fatty acid and yields a free fatty acid and lysophospholipid (Voet and Voet, 2004). TAG digestion is completed by the time the bolus reaches the mid-jejunum (Johnson, 2001). Since TAGs and fatty acids are hydrophobic, they coalesce into lipid droplets with hydrophobic tails in the center and hydrophilic heads towards the outside forming a micelle.…”

Section: Dietary Fatty Acid Absorptionmentioning

confidence: 99%

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Effects of maturation, polyploidy, and nutrition on growth, composition, and gene expression within fatty acid metabolism in rainbow trout

Manor¹

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Chapter 4: Differences in growth, fillet quality, and fatty acid metabolism-related gene expression between juvenile male and female rainbow trout Abstract……………………………………………………………………………………. Introduction………………………………………………………………………………... Materials and Methods…………………………………………………………………….. Results……………………………………………………………………………………... Discussion…………………………………………………………………………………. Conclusion………………………………………………………………………………… Acknowledgements………………………………………………………………………... Tables and Figures………………………………………………………………………… References…………………………………………………………………………………. Chapter 5: Associations of fillet yield and fat content with fillet texture, fatty acid composition, and fatty acid metabolism gene expression in female rainbow trout Abstract……………………………………………………………………………………. Introduction………………………………………………………………………………... Materials and Methods…………………………………………………………………….. Results……………………………………………………………………………………... Discussion…………………………………………………………………………………. Conclusion………………………………………………………………………………… Acknowledgements………………………………………………………………………... Tables and Figures………………………………………………………………………… References…………………………………………………………………………………. 171 Dissertiation Conclusion………………………………………………………………………. Appendices 1. Feeding Rate Study Tissue Fatty Acid Compositions (mg/g sample).………………... 178 2. Pathways with Multiplex-PCR Target Genes Highlighted……………………………. 182 3. Primer Sequences and Expected PCR Products for Multiplex-PCR Reactions………. 184 4. Genes within Fatty Acid Metabolism Targeted in GeXP-Multiplex PCR Analysis….. 185 5. Fillet fatty acid compositions (% fatty acid) of male and female rainbow trout……… 186 6. Fillet fatty acid compositions (% fatty acid) of immature female rainbow trout associated with fillet yield and crude fat content…………………………………….... 187 7.

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Digestion and Absorption

Cited by 12 publications

References 8 publications

Improvement of Oral Bioavailability of N-251, a Novel Antimalarial Drug, by Increasing Lymphatic Transport with Long-Chain Fatty Acid-Based Self-Nanoemulsifying Drug Delivery System

Improvement of Oral Bioavailability of N-251, a Novel Antimalarial Drug, by Increasing Lymphatic Transport with Long-Chain Fatty Acid-Based Self-Nanoemulsifying Drug Delivery System

Impact of absorption and transport on intelligent therapeutics and nanoscale delivery of protein therapeutic agents

Effects of maturation, polyploidy, and nutrition on growth, composition, and gene expression within fatty acid metabolism in rainbow trout

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