Digestion and absorption of polyunsaturated fatty acids

Carlier, H.; Bernard, A.; Caselli, C.

doi:10.1051/rnd:19910501

Cited by 107 publications

(57 citation statements)

References 47 publications

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“…Differences in absorption of the different FA could also arise from differences in enterocyte FA uptake from micelles (linked to FA solubility in water), differences in transport across the enterocyte membrane (Hamilton, 1998) or from different post-absorptive mechanisms (enterocyte FA metabolism). Monounsaturated FA are mainly integrated in TG, whereas polyunsaturated and trans-FA are mainly incorporated in phospholipids (Bernard et al, 1987, Carlier et al, 1991. The re-esterification of FA thus demands specific ratios of saturated and unsaturated FA, or its kinetics can differ between FA (Ockner et al, 1972).…”

Section: Digestion Of C18 Fatty Acids In Ruminantsmentioning

confidence: 99%

Digestion of fatty acids in ruminants: a meta-analysis of flows and variation factors: 2. C18 fatty acids

Glasser

Schmidely

Sauvant

et al. 2008

Animal

104

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In ruminants, dietary lipids are extensively hydrogenated by rumen micro-organisms, and the extent of this biohydrogenation is a major determinant of long-chain fatty acid profiles of animal products (milk, meat). This paper reports on the duodenal flows of C18 fatty acids and their absorption in the small intestine, using a meta-analysis of a database of 77 experiments (294 treatments). We established equations for the prediction of duodenal flows of various 18-carbon (C18) fatty acids as a function of the intakes of their precursors and other dietary factors (source and/or technological treatment of dietary lipids). We also quantified the influence of several factors modifying rumen metabolism (pH, forage : concentrate ratio, level of intake, fish oil supplementation). We established equations for the apparent absorption of these fatty acids in the small intestine as a function of their duodenal flows. For all C18 unsaturated fatty acids, apparent absorption was a linear function of duodenal flow. For 18:0, apparent absorption levelled off for high duodenal flows. From this database, with fatty acid flows expressed in g/kg dry matter intake, we could not find any significant differences between animal categories (lactating cows, other cattle or sheep) in terms of rumen metabolism or intestinal absorption of C18 fatty acids.

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Section: Digestion Of C18 Fatty Acids In Ruminantsmentioning

confidence: 99%

Digestion of fatty acids in ruminants: a meta-analysis of flows and variation factors: 2. C18 fatty acids

Glasser

Schmidely

Sauvant

et al. 2008

Animal

104

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“…Consumption of EFAs in sucient concentrations is of course a limiting factor that determines their concentrations in tissues. Additionally, FAs must ®rst cross the intestinal epithelium before reaching the dierent tissues, where digestion and absorption constitute further problems in their availability [23]. Carlier et al [23], showed that the EFAs taken up by tissues are recovered in relatively high proportions as components of phospholipids.…”

Section: Dietary Sources and Synthesis Of Essential Fatty Acidsmentioning

confidence: 99%

Essential fatty acids and the brain: possible health implications

Youdim

Martín

Joseph

2000

Intl J of Devlp Neuroscience

430

273

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Linoleic and a-linolenic acid are essential for normal cellular function, and act as precursors for the synthesis of longer chained polyunsaturated fatty acids (PUFAs) such as arachidonic (AA), eicosapentaenoic (EPA) and docosahexaenoic acids (DHA), which have been shown to partake in numerous cellular functions aecting membrane¯uidity, membrane enzyme activities and eicosanoid synthesis. The brain is particularly rich in PUFAs such as DHA, and changes in tissue membrane composition of these PUFAs re¯ect that of the dietary source. The decline in structural and functional integrity of this tissue appears to correlate with loss in membrane DHA concentrations. Arachidonic acid, also predominant in this tissue, is a major precursor for the synthesis of eicosanoids, that serve as intracellular or extracellular signals. With aging comes a likely increase in reactive oxygen species and hence a concomitant decline in membrane PUFA concentrations, and with it, cognitive impairment. Neurodegenerative disorders such as Parkinson's and Alzheimer's disease also appear to exhibit membrane loss of PUFAs. Thus it may be that an optimal diet with a balance of n-6 and n-3 fatty acids may help to delay their onset or reduce the insult to brain functions which these diseases elicit. Published by Elsevier Science Ltd.

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“…In humans, the coefficient of digestibility of the most common vegetable oils in 97-98%. Only hydrogenated oils, comprising high amounts of saturated and isomeric fatty acids, have lower coefficients (Deuel, 1955 (Deuel, 1955 (Brockerhoff et al, 1968 (Chen et al, 1985;Carlier et al, 1991) (Kinsella, 1991). Secondly, the L-FABP (liver-fatty acid binding protein) present in enterocytes, contrary to the I-FABP (intestinal-FABP), might exhibit higher affinity for PUFA than for others (Lowe et al, 1987) (Sprecher, 1981).…”

Section: Dietary Sources Of Essential Fatty Acidsmentioning

confidence: 99%

The metabolism and availability of essential fatty acids in animal and human tissues

Bézard

Blond²,

Bernard³

et al. 1994

Reprod. Nutr. Dev.

Self Cite

191

109

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Summary ― Essential fatty acids (EFA), which are not synthesized in animal and human tissues, belong to the n-6 and n-3 families of polyunsaturated fatty acids (PUFA), derived from linoleic acid (LA,) and a-linolenic acid (LNA,. Optimal requirements are 3-6% of ingested energy for LA and 0.5-1% for LNA in adults. Requirements in LNA are higher in development. Dietary sources of LA and LNA are principally plants, while arachidonic acid (AA,) is found in products from terrestrian animals, and eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)

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Digestion and absorption of polyunsaturated fatty acids

Cited by 107 publications

References 47 publications

Digestion of fatty acids in ruminants: a meta-analysis of flows and variation factors: 2. C18 fatty acids

Digestion of fatty acids in ruminants: a meta-analysis of flows and variation factors: 2. C18 fatty acids

Essential fatty acids and the brain: possible health implications

The metabolism and availability of essential fatty acids in animal and human tissues

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