Digestive and gastroprotective effects of Achillea erba-rotta subsp. moschata (Wulfen) I.Richardson (syn. A. moschata Wulfen) (Asteraceae): From traditional uses to preclinical studies

Vitalini, Sara; Garzoli, Stefania; Sisto, Francesca; Pezzani, Raffaele; Argentieri, Maria Pia; Scarafoni, Alessio; Ciappellano, Salvatore; Zorzan, Maira; Capraro, Jessica; Collazuol, Daniela

doi:10.1016/j.jep.2022.115670

Cited by 4 publications

(13 citation statements)

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“…Regarding the phytochemical profiling of the phenolic content of A. moschata , the literature proposed only five works. Two of these highlighted the quali-quantitative characterization of the methanolic extract [ 11 , 12 ]; one proposed the quali-quantitative analysis of the acetone/water extract, later solubilized in methanol/water [ 15 ]; one focused on the quantification of the total polyphenolic content of the methanolic fraction [ 10 ]; and, finally, a more recent work, proposed a quantitative comparison between the methanolic extract and the aqueous preparation, without presenting any chromatogram and fragmentation pattern of the listed compounds [ 9 ].…”

Section: Resultsmentioning

confidence: 99%

“…From a comparison with these papers [ 9 , 11 , 12 , 15 ], our phytochemical characterization identified the highest total number of compounds. The phenolic classes were found to be the same, including simple phenols (phenolic acids) and flavonoids (flavones and flavonols).…”

Section: Resultsmentioning

confidence: 99%

“…Concerning previous phytochemical studies, the literature proposed various works on the essential oil composition [ 7 , 8 , 9 ] and the polar extracts [ 9 , 10 , 11 , 12 ], as well as the non-polar and aqueous profiles [ 9 , 13 ], obtained from the dried flowered aerial parts. The acetonic extracts were also analyzed for the identification of the epicuticular components [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, studies never reported the aqueous extract, which is significant, being the traditional decoction used in folk medicine in the Alpine and Pre-alpine regions. Only recently, Vitalini et al [ 9 ] tested several extracts, including the aqueous one, for their anti-inflammatory activity, evaluating the modulation of interleukins 8 and 1β on CaCo-2 cells. Concerning congeneric species, the antioxidant potential of different extracts was evaluated as radical scavenger activity, but no in vitro studies were reported to date in the literature [ 10 , 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

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Achillea moschata Wulfen: From Ethnobotany to Phytochemistry, Morphology, and Biological Activity

et al. 2022

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A multidisciplinary investigation on Achillea moschata Wulfen (Asteraceae) is outlined herein. This work, part of the European Interreg Italy–Switzerland B-ICE project, originated from an ethnobotanical survey performed in Chiesa in Valmalenco (Sondrio, Lombardy, Northern Italy) in 2019–2021 which highlighted this species’ relevance of use in folk medicine to treat gastrointestinal diseases. In addition, this contribution included analyses of the: (a) phytochemical profile of the aqueous and methanolic extracts of the dried flower heads using LC-MS/MS; (b) morpho-anatomy and histochemistry of the vegetative and reproductive organs through Light, Fluorescence, and Scanning Electron Microscopy; (c) biological activity of the aqueous extract concerning the antioxidant and anti-inflammatory potential through cell-based in vitro models. A total of 31 compounds (5 phenolic acids, 13 flavonols, and 13 flavones) were detected, 28 of which included in both extracts. Covering and secreting trichomes were observed: the biseriate 10-celled glandular trichomes prevailing on the inflorescences represented the main sites of synthesis of the polyphenols and flavonoids detected in the extracts, along with volatile terpenoids. Finally, significant antioxidant and anti-inflammatory activities of the aqueous extract were documented, even at very low concentrations; for the first time, the in vitro tests allowed us to formulate hypotheses about the mechanism of action. This work brings an element of novelty due to the faithful reproduction of the traditional aqueous preparation and the combination of phytochemical and micromorphological research approaches.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Achillea moschata Wulfen: From Ethnobotany to Phytochemistry, Morphology, and Biological Activity

et al. 2022

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“…In fact, there have been various plant matrices reported with PNLIP inhibitory potency, for example, berry plants [ 9 ] or tea extracts [ 10 ]. Among them, plants belonging to the Asteraceae botanical family have attracted significant attention by the research community [ 11 , 12 ], focusing on testing extracts of differing polarity as well as different plant parts. The reason behind the warm interest on Asteraceae plants is that they are widely available all over the world with over 2500 plant species.…”

Section: Introductionmentioning

confidence: 99%

The In Vitro Inhibitory Effect of Selected Asteraceae Plants on Pancreatic Lipase Followed by Phenolic Content Identification through Liquid Chromatography High Resolution Mass Spectrometry (LC-HRMS)

Tsagkaris

Louckova

Jaegerova

et al. 2022

IJMS

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Pancreatic lipase (PNLIP, EC 3.1.1.3) plays a pivotal role in the digestion of dietary lipids, a metabolic pathway directly related to obesity. One of the effective strategies in obesity treatment is the inhibition of PNLIP, which is possible to be achieved by specific phenolic compounds occurring in high abundance in some plants. In this study, a multidisciplinary approach is presented investigating the PNLIP inhibitory effect of 33 plants belonging in the Asteraceae botanical family. In the first stage of the study, a rapid and cost-efficient PNLIP assay in a 96-microwell plate format was developed and important parameters were optimized, e.g., the enzyme substrate. Upon PNLIP assay optimization, aqueous and dichloromethane Asteraceae plant extracts were tested and a cut-off inhibition level was set to further analyze only the samples with a significant inhibitory effect (inhibitory rate > 40%), using an ultra-high-performance liquid chromatography hybrid quadrupole time-of-flight mass spectrometry (UHPLC-q-TOF-MS) method. Specifically, a metabolomic suspect screening was performed and 69 phenolic compounds were tentatively identified, including phenolic acids, flavonoids, flavonoid-3-O-glycosides, and flavonoid-7-O-glycosides, amongst others. In the case of aqueous extracts, phytochemicals known for inducing PNLIP inhibitory effect, e.g., compounds containing galloyl molecules or caffeoylquinic acids, were monitored in Chrysanthemum morifolium, Grindella camporum and Hieracium pilosella extracts. All in all, the presented approach combines in vitro bioactivity measurements to high-end metabolomics to identify phenolic compounds with potential medicinal and/or dietary applications.

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Non-Volatile Terpenoids and Lipophilic Flavonoids from Achillea erba-rotta Subsp. moschata (Wulfen) I. Richardson

Salamone

Aiello

Fusani

et al. 2023

Plants

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Musk yarrow (Achillea erba-rotta subsp. moschata (Wulfen) I. Richardson) is endemic to the Central Alps, and is used to flavour alcoholic beverages. Despite its popularity as aromatizing agent and its alleged beneficial effects on digestion, the phytochemical profile of the plant is still largely unknown and undiscovered. As a consequence, its authentication in aromatized products is impossible beyond sensory analysis allowing forgery. To address these issues, we phytochemically characterized a sample of musk yarrow from the Italian Eastern Alps, identifying, in addition to widespread phytochemicals (taraxasterol, apigenin), the guaianolides 3, 8, 9; the seco-caryophyllane 6; and the polymethoxylated lipophilic flavonoids 1, 4, and 5. The flavonoid xanthomicrol 1, a major constituent of the plant, was cytotoxic to HeLa cells, but only modestly affected primary 3T3 fibroblasts. On account of their stability, detectability by UV absorption, and concentration, the oxygenated flavonoids qualify as markers to validate the supply chain of the plant growers to consumers.

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Digestive and gastroprotective effects of Achillea erba-rotta subsp. moschata (Wulfen) I.Richardson (syn. A. moschata Wulfen) (Asteraceae): From traditional uses to preclinical studies

Cited by 4 publications

References 60 publications

Achillea moschata Wulfen: From Ethnobotany to Phytochemistry, Morphology, and Biological Activity

Achillea moschata Wulfen: From Ethnobotany to Phytochemistry, Morphology, and Biological Activity

The In Vitro Inhibitory Effect of Selected Asteraceae Plants on Pancreatic Lipase Followed by Phenolic Content Identification through Liquid Chromatography High Resolution Mass Spectrometry (LC-HRMS)

Non-Volatile Terpenoids and Lipophilic Flavonoids from Achillea erba-rotta Subsp. moschata (Wulfen) I. Richardson

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