Digestive pathway of infection in Streptococcus dysgalactiae polyarthritis in lambs

Lacasta, Delia; Ferrer, Luís Miguel; Ramos, Juan José; Loste, A.; Bueso, J.P.

doi:10.1016/j.smallrumres.2008.06.001

Cited by 24 publications

(20 citation statements)

References 10 publications

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“…dysgalactiae was reported to be associated with toxic shock-like syndrome in cattle (9), suppurative polyarthritis in lambs (28), bacteremia in dogs (66), and systemic granulomatous inflammatory disease and severe septicemia in fish (16) and in ascending upper limb cellulitis in humans in contact with raw fish (27). The presence of the streptococcal pyrogenic exotoxin G gene (spegg) and streptolysin S structural gene (sagA), which have been associated with invasive disease in the exclusively human pathogen Streptococcus pyogenes (group A Streptococcus [GAS]), has been documented for fish isolates of S. dysgalactiae subsp.…”

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confidence: 99%

Virulence Gene Pool Detected in Bovine Group C Streptococcus dysgalactiae subsp. dysgalactiae Isolates by Use of a Group A S. pyogenes Virulence Microarray

et al. 2011

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A custom-designed microarray containing 220 virulence genes of Streptococcus pyogenes (group A Streptococcus [GAS]) was used to test group C Streptococcus dysgalactiae subsp. dysgalactiae (GCS) field strains causing bovine mastitis and group C or group G Streptococcus dysgalactiae subsp. equisimilis (GCS/GGS) isolates from human infections, with the latter being used for comparative purposes, for the presence of virulence genes. All bovine and all human isolates carried a fraction of the 220 genes (23% and 39%, respectively). The virulence genes encoding streptolysin S, glyceraldehyde-3-phosphate dehydrogenase, the plasminogen-binding M-like protein PAM, and the collagen-like protein SclB were detected in the majority of both bovine and human isolates (94 to 100%). Virulence factors, usually carried by human beta-hemolytic streptococcal pathogens, such as streptokinase, laminin-binding protein, and the C5a peptidase precursor, were detected in all human isolates but not in bovine isolates. Additionally, GAS bacteriophage-associated virulence genes encoding superantigens, DNase, and/or streptodornase were detected in bovine isolates (72%) but not in the human isolates. Determinants located in non-bacteriophage-related mobile elements, such as the gene encoding R28, were detected in all bovine and human isolates. Several virulence genes, including genes of bacteriophage origin, were shown to be expressed by reverse transcriptase PCR (RT-PCR). Phylogenetic analysis of superantigen gene sequences revealed a high level (>98%) of identity among genes of bovine GCS, of the horse pathogen Streptococcus equi subsp. equi, and of the human pathogen GAS. Our findings indicate that alphahemolytic bovine GCS, an important mastitis pathogen and considered to be a nonhuman pathogen, carries important virulence factors responsible for virulence and pathogenesis in humans.

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confidence: 99%

Virulence Gene Pool Detected in Bovine Group C Streptococcus dysgalactiae subsp. dysgalactiae Isolates by Use of a Group A S. pyogenes Virulence Microarray

et al. 2011

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“…Similarly, Lacasta and others (2008) did not isolate S dysgalactiae from the nose, ear or vagina of 30 ewes who had lambs with S dysgalactiae joint ill. The low frequency of isolation suggests carriage of the organism is relatively infrequent.…”

Section: Discussionmentioning

confidence: 95%

“…The organism was identified in the milk of one ewe and similarly Lacasta and others (2008) tested milk samples from 95 ewes, and isolated S dysgalactiae from the milk of one ewe whose lamb subsequently developed joint ill. This may be a source of infection for some lambs.…”

Section: Discussionmentioning

confidence: 99%

“…Characteristics of the lambs themselves in terms of birth-weight, gender and litter size, did not appear to have any major influence on whether they develop joint ill (Rutherford 2012). In lambs, the umbilicus is proposed to be the most likely route of entry of S dysgalactiae (Blakemore 1939, Angus 1991), although the digestive pathway has also been suggested (Lacasta and others 2008). …”

Section: Discussionmentioning

confidence: 99%

“…Joint ill has been reported in the UK since the 1890s, but the literature regarding the biology of S dysgalactiae in sheep is limited. The organism has been isolated from the mouth and vagina from a small number of ewes (Cornell and Glover 1925, Anon 2006), and a milk sample from one ewe (Lacasta and others 2008). Environmental sources of the bacterium have not been investigated.…”

Section: Introductionmentioning

confidence: 99%

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Sources of Streptococcus dysgalactiae in English and Welsh sheep flocks affected by infectious arthritis (joint ill)

2014

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In order to investigate sheep sources of Streptococcus dysgalactiae in flocks affected with joint ill, 10 sheep flocks in England and Wales with laboratory-confirmed cases of infectious arthritis (joint ill) caused by S dysgalactiae were visited during a disease outbreak while a further four flocks were visited during the lambing period in the year following an outbreak. A total of 5239 samples were collected for bacterial culture from 797 ewes and their 1314 lambs. S dysgalactiae was isolated from nine of 894 samples (1 per cent) on farms visited during an outbreak, and from 7 of 4462 samples (0.2 per cent) collected in the year following an outbreak. The 16 samples from which S dysgalactiae was isolated came from the vaginas of eight ewes, milk of one ewe, navels of four lambs, mouths of two lambs and noses of one lamb. In vitro testing of the survival of S dysgalactiae on straw, hay and in water at different temperatures was performed, and it was isolated from these substrates for up to 42, 35 and 0 days, respectively.

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Diseases of the Musculoskeletal System

2017

Veterinary Medicine

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Digestive pathway of infection in Streptococcus dysgalactiae polyarthritis in lambs

Cited by 24 publications

References 10 publications

Virulence Gene Pool Detected in Bovine Group C Streptococcus dysgalactiae subsp. dysgalactiae Isolates by Use of a Group A S. pyogenes Virulence Microarray

Virulence Gene Pool Detected in Bovine Group C Streptococcus dysgalactiae subsp. dysgalactiae Isolates by Use of a Group A S. pyogenes Virulence Microarray

Sources of Streptococcus dysgalactiae in English and Welsh sheep flocks affected by infectious arthritis (joint ill)

Diseases of the Musculoskeletal System

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