Digestive System

Greaves, Peter

doi:10.1016/b978-044452771-4/50009-2

Cited by 5 publications

(5 citation statements)

References 455 publications

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“…Goblet cells in the large intestines of humans, rats, mice, dogs, and nonhuman primates produce sulphomucin and sialomucin in varying proportions. 15 Previous studies indicated that mucin profiles are associated with the biological behavior of human colorectal tumors. 4,16,29,45,48 Similarly, the predominance of sialomucin in the colon is a precursor change in the experimental models of colorectal carcinogenesis in rats.…”

Section: Discussionmentioning

confidence: 99%

“…The nuclear accumulation of b-catenin and p53 was detected in 30/50 (60%; 3 TA, 21 TAC, 1 VA, 1 TVA, 3 TVAC, and 1 MAC) and 29/50 cases (58%; 2 TA, 21 TAC, 2 VA, and 4 TVAC), respectively (Figs. 15,16). However, only 2/50 (4%, 2 TAC) and 5/50 (10%, 3 TAC, 1 TA, and 1TVAC) cases displayed nuclear accumulation of b-catenin and p53 in more than 75% of tumor cells, respectively.…”

Section: Immunohistochemical Featuresmentioning

confidence: 97%

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Histological Classification and Immunohistochemical Study of Feline Colorectal Epithelial Tumors

et al. 2020

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Among 113 feline gastrointestinal epithelial tumors diagnosed between 2006 and 2019, 78 (69%) were detected in the colorectum. Fifty colorectal tumors were selected for further pathological evaluations, of which 9 (18%) were histopathologically diagnosed as adenomas and 41 (82%) as carcinoma. The carcinomas included 33 tubular adenocarcinomas (TAC), 5 tubulovillous adenocarcinomas (TVAC), 2 mucinous adenocarcinomas, and 1 undifferentiated carcinoma. Histopathologically, TAC frequently showed vascular invasion (17/33 cases, 52%). In TAC cases, serosal infiltration (13/15 cases, 87%) and lymph node metastasis (8/9 cases, 89%) were common in bowel resection and lymphadenectomy samples, respectively. Immunohistochemically, the tumor cells of most cases were positive for cytokeratin (CK) 20 (50/50 cases, 100%) and CDX2 (48/50 cases, 96%). Focal immunopositivity for CD10 (11/50 cases, 22%) and CK7 (15/50 cases, 30%) was observed irrespective of the histological subtype. Only a few cases showed diffuse nuclear accumulation of β-catenin (2/50 cases, 4%) and p53 (5/50 cases, 10%). A lack of tubule formation, female sex, and low CDX2 labeling were statistically associated with carcinoma compared to adenoma (ρ = 0.615, P < .001; ρ = 0.279, P = .050; and ρ = −0.265, P = .063, respectively). Other features, including mucin profiles, Ki67 labeling index, and accumulation of β-catenin and p53, were not associated with malignancy. A sequence analysis revealed KRAS mutations in 3/7 TAC cases. These results suggest that KRAS mutations—rather than excessive Wnt/β-catenin signaling and the inactivation of TP53—contribute to the tumorigenesis of feline colorectal carcinoma.

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Section: Discussionmentioning

confidence: 99%

Section: Immunohistochemical Featuresmentioning

confidence: 97%

Histological Classification and Immunohistochemical Study of Feline Colorectal Epithelial Tumors

et al. 2020

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“…While the potential phytochemical substances that have also been identified by the previous scientific reports (Jansen et al, ) might have served as the evidence of the positive effect, the high level of grayanotoxin contents might have evaluated as the reason for the unusual situation, and they might have supported to bleed in the lesion area (Figures and ). According to Greaves (), a high dose of some chemicals causes the bleeding lesions and the focal damage to the gastric mucosa with direct effects.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of aqueous extracts of some honeys against HCl/ethanol‐induced gastric ulceration in rats

et al. 2019

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This study focused on the concept of the possible protective effect of some honey types against HCl/ethanol‐induced gastric ulcers in male Wistar albino rats. Rats were pretreated with rhododendron, chestnut, and oak honey orally with doses of 1.25 and 2.5 g/kg, bw (body weight) for three consecutive days. On fourth day, nothing was applied, and after the administration of anesthesia on the fifth day, their stomachs were surgically removed to investigate the histopathological examinations. Besides analyses of some blood serum profiles and antioxidant parameters of gastric tissue, some biochemical properties of honeys were investigated to support the histopathological results. The degrees of ulcer lesions in all groups revealed a statistically significant difference (p = .011). Although this difference originated from the additional ulcerative inducing effect of some honeys, the lower concentration rhododendron honey indicated more promising data than the positive control group (pantoprazole) in consequence of the microscopic and macroscopic evaluations. Practical applications As being a member of natural products, honey has acquired fame among the studies in recent years due to its versatility as a source of food and complementary medicine. For contributing to this argument, this comprehensive study was performed and results were focused on the lower concentration of rhododendron honey thanks to its clinical potential with protecting the gastric mucosa. According to the obtained results, our suggestion came into prominence that this honey might be protecting the mucosa, better than the different concentrations of chestnut and oak honeys, by being better‐absorbed through the gastric mucosa.

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“…Necrosis, hemorrhages, steatosis in hepatocytes, cell shrinking, nuclear enlargement or pyknosis, chromatin condensation, ruptured cell membranes, and apoptotic bodies were evaluated as potential signs of liver and kidney toxicity. 36 The extent of tumor necrosis was quantified on H&E-stained slides by evaluating the percent of tumor necrotic area by the visual assessment of an experienced pathologist. Statistical Analysis.…”

Section: Inorganicmentioning

confidence: 99%

Coordination of Ru(II)-Arene Fragments to Dipyridophenazine Ligands Leads to the Modulation of Their In Vitro and In Vivo Anticancer Activity

Nikolić,

Arakelyan,

Kushnarev

et al. 2023

Inorg. Chem.

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Despite extensive research on the anticancer properties of Ru complexes with dipyrido[3,2-a:2′,3′-c]phenazine (dppz) ligands, their in vivo efficacy is rarely investigated. Aiming to understand whether the coordination of certain half-sandwich Ru(II)-arene fragments might improve the therapeutic potential of dppz ligands, we prepared a series of Ru(II)-arene complexes with the general formula [(η 6 -arene)Ru(dppz-R)Cl]PF 6 , where the arene fragment was benzene, toluene, or p-cymene and R was -NO 2 , -Me, or -COOMe. All compounds were fully characterized by 1 H and 13 C NMR spectroscopy and highresolution ESI mass-spectrometry, and their purity was verified by elemental analysis. The electrochemical activity was investigated using cyclic voltammetry. The anticancer activity of dppz ligands and their respective Ru complexes was assessed against several cancer cell lines, and their selectivity toward cancer cells was assessed using healthy MRC5 lung fibroblasts. The substitution of benzene with a p-cymene fragment resulted in a more than 17-fold increase of anticancer activity and selectivity of Ru complexes and significantly enhanced DNA degradation in HCT116 cells. All Ru complexes were electrochemically active in the biologically accessible redox window and were shown to markedly induce the production of ROS in mitochondria. The lead Ru-dppz complex significantly reduced tumor burden in mice with colorectal cancers without inducing liver and kidney toxicity.

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Digestive System

Cited by 5 publications

References 455 publications

Histological Classification and Immunohistochemical Study of Feline Colorectal Epithelial Tumors

Histological Classification and Immunohistochemical Study of Feline Colorectal Epithelial Tumors

Protective effects of aqueous extracts of some honeys against HCl/ethanol‐induced gastric ulceration in rats

Coordination of Ru(II)-Arene Fragments to Dipyridophenazine Ligands Leads to the Modulation of Their In Vitro and In Vivo Anticancer Activity

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