Digestive System and Severe Acute Respiratory Syndrome Coronavirus 2: New Era of Microbiome Study and Gastrointestinal Tract Manifestations during the Coronavirus Disease-19 Pandemic

Kossumov, Alibek; Mussabay, Karakoz; Pepoyan, Astghik; Tsaturyan, Vardan; Sidamonidze, Ketevan; Tsereteli, David; Supiyev, Adil; Kozhakhmetov, Samat; Chulenbayeva, Laura; Dusmagambetov, Marat; Pignatelli, Massimo; Zhumadilov, Zhaxybay; Marotta, Francesco; Kushugulova, Аlmagul

doi:10.3889/oamjms.2021.7470

Cited by 3 publications

(1 citation statement)

References 64 publications

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“…Literature on SARS-CoV-2-alpha, -beta (Guan et al, 2020 ; Hussain et al, 2020 ; Kossumov et al, 2021 ), -gamma and -delta variants indicate a link between the severity of COVID-19 and diabetes (Bachache et al, 2022 ). Moreover, the majority of patients with COVID-19 are prone to impaired glucose metabolism, which emphasizes the importance of controlling the glucose metabolism of patients even if they have not had problems with it before (Wang et al, 2020 ; Bachache et al, 2022 ; Yonekawa and Shimono, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Host genetics and gut microbiota composition: Baseline gut microbiota composition as a possible prognostic factor for the severity of COVID-19 in patients with familial Mediterranean fever disease

et al. 2023

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BackgroundIt is known that the gut microbiome of a healthy person affects the process of COVID-19 after getting infected with SARS-CoV-2 virus. It is also believed that colchicine can alleviate the severity of COVID-19.ObjectiveCurrent investigations aimed to evaluate the associations between the baseline gut microbiota composition of healthy and Familial Mediterranean fever (FMF) - carrier Armenian men populations, and the severity of the COVID-19 disease after their infection with the SARS-CoV-2. The study has a purpose of answering three core questions: i. Do the characteristics of gut microbiome of Armenians affect the course of COVID-19 severity? ii. How does the COVID-19 disease course on go for FMF patients who have been taking colchicine as a medication over the years after getting infected with SARS-CoV-2? iii. Is there an initial gut micribiota structure pattern for non-FMF and FMF patients in the cases when COVID-19 appears in mild form?MethodsThe gut microbiota composition in non-FMF and FMF patients before the first infection (mild and moderate course of COVID-19) was considered. COVID-19 was diagnosed by SARS-CoV-2 nucleic acid RT-PCR in nasopharyngeal swab and/or sputum.ResultsThe number of patients with male FMF with mild COVID-19 was approximately two times higher than that of non-FMF male subjects with COVID-19. In addition, an association of COVID-19 disease severity with the baseline gut Prevotella, Clostridium hiranonis, Eubacterium biforme, Veillonellaceae, Coprococcus, and Blautia diversities in the non-FMF and FMF populations were revealed by us, which can be used as risk/prognostic factor for the severity of COVID-19.

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Section: Introductionmentioning

confidence: 99%

Host genetics and gut microbiota composition: Baseline gut microbiota composition as a possible prognostic factor for the severity of COVID-19 in patients with familial Mediterranean fever disease

et al. 2023

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Gut Microbiome and Cytokine Profiles in Post-COVID Syndrome

Mussabay,

Kozhakhmetov,

Dusmagambetov

et al. 2024

Viruses

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Recent studies highlight the crucial role of the gut microbiome in post-infectious complications, especially in patients recovering from severe COVID-19. Our research aimed to explore the connection between gut microbiome changes and the cytokine profile of patients with post-COVID syndrome. Using 16S rRNA amplicon sequencing, we analyzed the composition of the gut microbiome in 60 COVID-19 patients over the course of one year. We also measured the levels of serum cytokines and chemokines using the Milliplex system. Our results showed that severe SARS-CoV-2 infection cases, especially those complicated by pneumonia, induce a pro-inflammatory microbial milieu with heightened presence of Bacteroides, Faecalibacterium, and Prevotella_9. Furthermore, we found that post-COVID syndrome is characterized by a cross-correlation of various cytokines and chemokines MDC, IL-1b, Fractalkine, TNFa, FGF-2, EGF, IL-1RA, IFN-a2, IL-10, sCD40L, IL-8, Eotaxin, IL-12p40, and MIP-1b as well as a shift in the gut microbiome towards a pro-inflammatory profile. At the functional level, our analysis revealed associations with post-COVID-19 in homolactic fermentation, pentose phosphate, NAD salvage, and flavin biosynthesis. These findings highlight the intricate interplay between the gut microbiota, their metabolites, and systemic cytokines in shaping post-COVID symptoms. Unraveling the gut microbiome’s role in post-infectious complications opens avenues for new treatments for those patients with prolonged symptoms.

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Promising Indicators in Probiotic-recommendations in COVID-19 and its Accompanying Diseases

Tsaturyan

Kushugulova

Mirzabekyan

et al. 2022

Open Access Maced J Med Sci

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Scientific data suggests the possible beneficial role of probiotics in treatments for COVID-19, but the species/strains-specificity and disease-specificity of probiotics need high attention in choosing the appropriate probiotic in diseases, in particularly in the COVID-19. We hope this review will raise awareness of the COVID-19 probiotic recommendations, highlighting the latest scientific information about virus/hydrogen peroxide/probiotics and the importance of finding out of a specific “criterion” for the probiotics’ recommendation in this disease.

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Digestive System and Severe Acute Respiratory Syndrome Coronavirus 2: New Era of Microbiome Study and Gastrointestinal Tract Manifestations during the Coronavirus Disease-19 Pandemic

Cited by 3 publications

References 64 publications

Host genetics and gut microbiota composition: Baseline gut microbiota composition as a possible prognostic factor for the severity of COVID-19 in patients with familial Mediterranean fever disease

Host genetics and gut microbiota composition: Baseline gut microbiota composition as a possible prognostic factor for the severity of COVID-19 in patients with familial Mediterranean fever disease

Gut Microbiome and Cytokine Profiles in Post-COVID Syndrome

Promising Indicators in Probiotic-recommendations in COVID-19 and its Accompanying Diseases

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