Digital-Based Interventions Targeting School Failure: A Systematic Review

Azevedo, Ricardo Cabral de; Costa, Ana Cristina Figueiredo de Melo; Moreira, Diana; Azevedo, Ângela Sá; Oliveira, Íris M.; Gonçalves, Armanda; Casanova, Joana R.; Dias, Paulo C.

doi:10.21125/iceri.2022.1943

Cited by 1 publication

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“…Two literature values were obtained for the octanol−water partition coefficient of naproxen. 33,35,47 The difference between the results in the assay (Table 2) and those in previous studies 33,35,47 is likely due to the different experimental methods.…”

Section: Glass Transition (T G ) Values Of [Ch][nap] [Ben][nap] and [...mentioning

confidence: 72%

“…The observed toxic alterations confirmed that choline influenced the toxicity of [Ch][Nap]. 35 An automated system was investigated to study the interaction of [Ch][Nap] with human serum albumin (HSA). 36 Balk et al 30 reported tetrabutyl phosphonium naproxen ([Tbp][Nap]), which had a lower melting point and glass transition temperature.…”

Section: ■ Introductionmentioning

confidence: 73%

“…Swiatek et al 33 reported the conversion of naproxen into naproxen-based IL, L-proline alkyl ester naproxen ([ProOR]-[Nap]), suggesting the improved solubility and higher absorption of drug molecules by biological membranes. ) showed an aqueous solubility (at pH 7.4) 31,35 up to 100 times higher than the solubility of the naproxen precursor. 31 The addition of [Ch][Nap] into bacterial cellulose (BC) formed the transparent and homogeneous membranes, which further improved the absorption ability of phosphate-buffered saline (PBS) solution compared with the BC-naproxen.…”

Section: ■ Introductionmentioning

confidence: 90%

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Evaluation of Solubility, Physicochemical Properties, and Cytotoxicity of Naproxen-Based Ionic Liquids

et al. 2023

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To solve the problems associated with poorly water-soluble nonsteroidal anti-inflammatory drugs (NSAIDs), naproxen-based ionic liquids (ILs) containing naproxen as an active pharmaceutical ingredient (API) anion were prepared with benzalkonium (tetradecyldimethylbenzyl ammonium), choline, and 1-octyl-3-methylimidazole as the cation. The structures and thermal properties were analyzed. Through the conductivity method, the solubility at 25 and 37 °C and the critical micelle concentration (CMC) at 25 °C were determined in water and ethanol. The octanol−water partition coefficients (K ow ) at 25 °C were measured with the shake-flask method. The cytotoxicity was evaluated with the MTT method. The results showed that the conversion of naproxen into the API-ILs increased the API's solubility in water by more than 850 times compared with the original API, and the thermostability was satisfactory with a lower glass transition temperature (t g ). Moreover, the variation trends of solubility, hydrophilicity, and K ow were consistent with the different structures of naproxen-based ILs, except for benzalkonium naproxen. The CMC (10 −5 −10 −6 M) in water and ethanol demonstrated that the naproxen-based ILs were surface activite ILs. The IC 50 values exhibited the low cytotoxicity of the naproxen-based ILs, which was better than 100 μM. The results provide essential information and a research basis for future topical and transdermal administration and oral administration of naproxen-based ILs.

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