Digital Dentistry and Dental Informatics

Tsoi, KH

doi:10.1201/b15644-20

Cited by 4 publications

(3 citation statements)

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“…The increase of mean opacity ratio from third week to eighth week following surgery was stronger in the PMMA group than in the HLBC group ( Fig 4A ). However, in previous publications it was indicated that the PMMA enhanced bone formation less exquisitely and it was delayed when compared to HLBC's bone formation enhancement [ 28 , 29 ]. Indeed, the low mean opacity value in the PMMA group at third week after surgery was reflected in the mean opacity ratio (Figs 3A and 4A ).…”

Section: Discussionmentioning

confidence: 99%

“…However, the HLBC showed a strong positive significant correlation between the increased opacity ratio and the decreased Tc-99m MDP activity. Probably because revascularization of the cancellous autografts takes place earlier than the cortical grafts’, as early as the fifth day following implantation, due to their porous architecture [ 28 , 29 ]. In addition, in the HLBC group the creeping-substitution mechanism has enhanced vascularization and albumin-coated surface promoted osseointegration [ 24 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

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Novel radiomics evaluation of bone formation utilizing multimodal (SPECT/X-ray CT) in vivo imaging

et al. 2018

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Although an extensive research is being undertaken, the ideal bone graft and evaluation method of the bone formation draw still a warranted attention. The purpose of this study was to develop a novel multimodal radiomics evaluation method, utilizing X-ray computed tomography (CT) and single photon emission computed tomography (SPECT) with Tc-99m-Methyl diphosphonate (Tc-99m-MDP) tracer. These modalities are intended to provide quantitative data concerning the mineral bone density (after evaluation it is referred to as opacity) and the osteoblast activity, at the same time. The properties of bone formation process within poly (methyl methacrylate)-based bone cement graft (PMMA) was compared to that of albumin coated, sterilized, antigen-extracted freeze-dried human bone grafts (HLBC), in caudal vertebrae (C5) of rats. The animals were scanned at 3 and 8 weeks after surgery. In both groups, the mean opacity increased, while the mean Tc-99m-MDP activity decreased. The later parameter was significant (n = 4, p = 0.002) only in HLBC group. The linear regression analysis of PMMA-treated group variables (mean opacity increase; mean Tc-99m-MDP activity decrease), revealed a negative correlation with the medium strength (r = 0.395, p = 0.605). Whereas, it showed strong positive correlation when HLBC group variables were analyzed (r = 0.772, p = 0.012). These results indicate that using HLBC grafts is advantageous in terms of the osteoblast activity and bone vascularization over PMMA cement. Using this regression analysis method, we were able to distinguish characteristics that otherwise could not be distinguished by a regular data analysis. Hence, we propose utilizing this novel method in preclinical tests, and in clinical monitoring of bone healing, in order to improve diagnosis of bone-related diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Novel radiomics evaluation of bone formation utilizing multimodal (SPECT/X-ray CT) in vivo imaging

et al. 2018

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“…Wang et al used ultra-performance liquid chromatography (UPLC) mass spectrometry in a hydrophilic interaction chromatography (HILIC) mode—and identified choline, betaine, pipecolinic acid, l -carnitine, l -leucine, and l -phenylalanine in saliva using a metabolomics approach, and from this study the authors were able to report a novel metabolite biomarker for the early diagnosis of squamous cell carcinoma [ 10 , 11 ]. Overall, with the aid of proteomic approaches researchers have been able to identify over 1000 salivary protein biomarkers including secretory immunoglobulin A, lactoperoxidase, statherin, proline-rich glycoprotein, truncated cystatin S, cystatins, lysozyme, and histatin-5, among others [ 12 , 13 , 14 , 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Human Saliva Collection Devices for Proteomics: An Update

Khurshid

Zohaib

Najeeb

et al. 2016

IJMS

132

106

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There has been a rapid growth in the interest and adaptation of saliva as a diagnostic specimen over the last decade, and in the last few years in particular, there have been major developments involving the application of saliva as a clinically relevant specimen. Saliva provides a “window” into the oral and systemic health of an individual, and like other bodily fluids, saliva can be analyzed and studied to diagnose diseases. With the advent of new, more sensitive technologies to detect smaller concentrations of analytes in saliva relative to blood levels, there have been a number of critical developments in the field that we will describe. In particular, recent advances in standardized saliva collection devices that were not available three to four years ago, have made it easy for safe, simple, and non-invasive collection of samples to be carried out from patients. With the availability of these new technologies, we believe that in the next decade salivary proteomics will make it possible to predict and diagnose oral as well as systemic diseases, cancer, and infectious diseases, among others. The aim of this article is to review recent developments and advances in the area of saliva specimen collection devices and applications that will advance the field of proteomics.

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Achieving enhanced bone regeneration using monetite granules with bone anabolic drug conjugates (C3 and C6) in rat mandibular defects

et al. 2020

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Bone grafting procedures are commonly used to manage bone defects in the craniofacial region. Monetite is an excellent biomaterial option for bone grafting, however, it is limited by lack of osteoinduction. Several molecules can be incorporated within the monetite matrix to promote bone regeneration. The aim was to investigate whether incorporating bone forming drug conjugates (C3 and C6) within monetite can improve their ability to regenerate bone in bone defects. Bilateral bone defects were created in the mandible of 24 Sprague–Dawley rats and were then packed with monetite control, monetite+C3 or monetite+C6. After 2 and 4 weeks, post‐mortem samples were analyzed using microcomputed tomography, histology and back‐scattered electron microscopy to calculate the percentages of bone formation and remaining graft material. At 2 and 4 weeks, monetite with C3 and C6 demonstrated higher bone formation than monetite control, while monetite+C6 had the highest bone formation percentage at 4 weeks. There were no significant differences in the remaining graft material between the groups at 2 or 4 weeks. Incorporating these anabolic drug conjugates within the degradable matrix of monetite present a promising bone graft alternative for bone regeneration and repair in orthopedic as well as oral and maxillofacial applications.

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Digital Dentistry and Dental Informatics

Cited by 4 publications

References 0 publications

Novel radiomics evaluation of bone formation utilizing multimodal (SPECT/X-ray CT) in vivo imaging

Novel radiomics evaluation of bone formation utilizing multimodal (SPECT/X-ray CT) in vivo imaging

Human Saliva Collection Devices for Proteomics: An Update

Achieving enhanced bone regeneration using monetite granules with bone anabolic drug conjugates (C3 and C6) in rat mandibular defects

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