The primary goal of the research is to identify the role of entrepreneurship based on high technology and digitalization in sustainable development. Sustainable development is a multidimensional phenomenon that includes economic, social, and environmental components, and it is viewed in the paper as a result of basic entrepreneurial activities and entrepreneurship in the high-tech sector, which significantly implies business/ entrepreneurial processes supported by digitalization. The establishment and growth of entrepreneurial organizations represent the principal drivers of structural changes towards sustainable development. Accordingly, sustainable development needs the support of innovative activities as carriers of changes in the new development paradigm to adjust to current and future challenges. The area of research in the paper consists of the previously mentioned three research units represented by 16 fundamental variables. In the paper three new variables were generated as a result of a regression factor by grouping the previously mentioned individual variables while using multiple regression as the primary method. A check of the research hypothesis was carried out, whose primary specificity is that all independent variables are simultaneously entered into the equation, which evaluates the predictive power of each independent variable. The paper used a sample of 49 countries classified into three groups according to the methodology of the World Economic Forum (WEF). The database for the needs of quantitative procedures concerning the variables of entrepreneurship and high-tech entrepreneurship is from the GEM project. For the variables of sustainable development, the following databases were used: the International Monetary Fund (IMF), IMF World Economic Outlook Data Base, Human Development Report, UNDP, Environmental Performance Index, and Yale University in collaboration with the WEF. Respecting the previously defined model in which sustainable development represents the function of entrepreneurship and high-tech (digital) entrepreneurship, the fundamental research assumption was confirmed, that is, it was determined that there is a positive correlation at the level of statistical significance between sustainable development as a dependent variable, and entrepreneurship and high-tech (digital) entrepreneurship as a group of independent variables.