This paper presents potential improvements through utilizing the cyclical nature of clusters by human capital, technology, policies, and management. A historical review of the formation and sustainable development of clusters in the US, Europe, Japan, China, and other regions is carried out to achieve this. The aim was to identify and assess the prominent occurrence cases, the central institutional actors, the indicators of their innovative activity, and the schematics of successful cluster management. The theory section covers current classification methods and typology of innovation-territorial economic associations. Consequently, a regression analysis model is produced to identify the potential dominant success factors in implementing the innovation policy of the most successful innovative clusters. Comments on the influence of these predictors on the competitiveness and level of innovative development of the 50 inspected countries follow. As a result of qualitative and quantitative analysis, an overview of the best world practice, the new vision, and its priorities are proposed to improve the efficiency at the level of management structures of innovation clusters.