Digital image analysis of the effect of topically applied linoleic acid on acne microcomedones

Abstract

A major pathogenic factor of acne is the disturbed keratinization of the follicular infundibulum. It has been hypothesized that a relative decrease in linoleic acid in the sebum could be responsible, in part, for this. The aim of the present study was objectively to evaluate the effects of topically applied linoleic acid on the size of microcomedones in patients with mild acne. The design was a double-blind placebo-controlled randomized cross-over study. Evaluations were performed by digital image analysis of cyanoacrylate follicular biopsies. There was a significant effect of topically applied linoleic acid on the size of follicular casts and microcomedones, an almost 25% reduction in their overall size being achieved over a 1-month treatment period. In contrast, no change was found at placebo-treated sites. It is concluded that topical linoleic acid might play a role as a comedolytic agent in acne-prone patients.

Transplastomic tobacco plants expressing a fatty acid desaturase gene exhibit altered fatty acid profiles and improved cold tolerance

“…The results obtained may have implication for the proposed industrial use of tobacco seed oil for paints or as an alternative diesel fuel (Crawford and Hilditch 1950;Giannelos et al 2002). In addition, the increase of linoleic acid, an essential FA for mammals, in plant seeds has interesting implications in dermatology (Letawe et al 1998;Darmstadt et al 2002) and nutraceutics, since it can be used to produce conjugated or long-chain polyunsaturated FAs (Hornung et al 2004;Graham et al 2007).…”

Evaluation of lipid biosynthesis ability by Rhodotorula and Sporobolomyces strains in medium with glycerol

“…It has been considered an anti-obesity agent and can be useful in the weight reduction process [11]. Linoleic acid has also become increasingly popular in the cosmetics industry because of its beneficial anti-inflammatory, acne reductive and moisture retentive properties on the skin [12,14,26]. The principal natural sources of CLA in the human diet are meat and dairy products from ruminant animals (such as milk, butter, yogurt and cheese).…”

Prospects of fatty acid profile and bioactive composition from lipid seeds for the discrimination of apple varieties with the application of chemometrics

“…Due to the significant level of unsaponifiable components such as tocopherols and sterols, the apple seed oil could be used in functional foods. Furthermore, the apple seed oil has great potential to be considered as a good source of oil for cosmetics, pharmaceutical, and edible purposes (Letawe et al 1998;Darmstadt et al, 2002;Yukui et al, 2009 Figure 5. Dedrogram for four apple varieties using unsaponifiable and fatty acid composition of RGA (Royal Gala apple), RDA (Red Delicious apple), GDA (Golden Delecious apple), PMA (Pyrus Malus apple).…”